{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:10:50Z","timestamp":1790784650845,"version":"4.1.0"},"reference-count":8,"publisher":"SLACK, Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Ophthalmol Strabismus"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>Alstr\u00f6m syndrome is a multisystemic disorder characterized by cone\u2013rod dystrophy, hearing loss, obesity, insulin resistance and hyperinsulinemia, type 2 diabetes mellitus, dilated cardiomyopathy, and progressive hepatic and renal dysfunction. The cone\u2013rod retinal dystrophy usually develops within a few weeks after birth. The authors examined a young boy with Alstr\u00f6m syndrome by means of microperimetry and spectral domain optical coherence tomography (OCT). Instead of the typical alterations observed in cone\u2013rod dystrophies, the characteristics of the central foveal tissue suggest signs of retinal immaturity, with only a single layer of short, thick cones and rods and immature short outer segments. High-speed and high-resolution spectral domain OCT allowed a detailed analysis of retinal layers in a young patient with Alstr\u00f6m syndrome for the first time.<\/jats:p>","DOI":"10.3928\/01913913-20100507-05","type":"journal-article","created":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T14:30:59Z","timestamp":1276266659000},"page":"1-3","source":"Crossref","is-referenced-by-count":11,"title":["High-Resolution Spectral Domain Optical Coherence Tomography Images of Alstr\u00f6m Syndrome"],"prefix":"10.3928","volume":"47","author":[{"given":"Enzo Maria","family":"Vingolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Luigi","family":"Grenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Maffei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Milan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","first-page":"1","article-title":"Retinal degeneration combined with obesity, diabetes mellitus and neurogenous deafness: a specific syndrome (not hitherto described) distinct from the Laurence-Moon-Bardet-Biedl syndrome: a clinical, endocrinological and genetic examination based on a large pedigree","volume":"129","author":"Alstr\u00f6m CH","year":"1959","unstructured":"Alstr\u00f6m CH, Hallgren B, Nilsson LB, Asander A. Retinal degeneration combined with obesity, diabetes mellitus and neurogenous deafness: a specific syndrome (not hitherto described) distinct from the Laurence-Moon-Bardet-Biedl syndrome: a clinical, endocrinological and genetic examination based on a large pedigree. Acta Psychiatr Neurol Scand Suppl. 1959;129:1\u201335.","journal-title":"Acta Psychiatr Neurol Scand Suppl"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2007.28"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201933"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.5.1581"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.68.7.494"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)97033-6"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01120-X"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34247-6"}],"container-title":["Journal of Pediatric Ophthalmology &amp; Strabismus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/01913913-20100507-05","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T20:20:05Z","timestamp":1685564405000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01913913-20100507-05"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.3928\/01913913-20100507-05"],"URL":"https:\/\/doi.org\/10.3928\/01913913-20100507-05","relation":{},"ISSN":["0191-3913","1938-2405"],"issn-type":[{"value":"0191-3913","type":"print"},{"value":"1938-2405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}