{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:08:04Z","timestamp":1790834884889,"version":"4.1.0"},"reference-count":33,"publisher":"SLACK, Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Ophthalmol Strabismus"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study assessed the effectiveness of the use of ketorolac tromethamine to reduce retinopathy of prematurity (ROP) incidence and its progression to more severe forms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty-seven preterm newborn infants with a birth weight (BW) of 1,000 grams or less and\/or a gestational age (GA) of 29 weeks or less were enrolled in the study when avascular retina zone I or ROP any stage were diagnosed at screening. Studied infants were randomized to receive ketorolac tromethamine ophthalmic solution in one eye and a drop of placebo in the other eye, until ROP requiring treatment or full retinal vascularization was diagnosed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Only 2 newborn infants did not develop ROP. Among 45 newborn infants who developed ROP, 6 showed different ROP staging between the two eyes, 4 of which had a better outcome in the eye receiving ketorolac tromethamine. The differences between ROP stagings were not significant even when analyzed by GA and BW subgroups. No significant treatment-related side effects occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This report suggests that ketorolac tromethamine ophthalmic solution cannot reduce the risk of developing severe ROP in preterm infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3928\/01913913-20100920-01","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T15:34:10Z","timestamp":1285688050000},"page":"247-251","source":"Crossref","is-referenced-by-count":18,"title":["Effectiveness of Ketorolac Tromethamine in Prevention of Severe Retinopathy of Prematurity"],"prefix":"10.3928","volume":"48","author":[{"given":"Carmen","family":"Giannantonio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Papacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velia","family":"Purcaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael Ghennet","family":"Tesfagabir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Molle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Lepore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Baldascino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Romagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","first-page":"227","article-title":"Childhood blindness in the context of VISION 2020-the right to sight","volume":"79","author":"Gilbert C","year":"2001","unstructured":"Gilbert C, Foster A. Childhood blindness in the context of VISION 2020-the right to sight. Bull World Health Organ. 2001;79:227\u2013232.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70031-3"},{"key":"e_1_3_2_4_2","first-page":"CD001073","article-title":"D-Penicillamine for preventing retinopathy of prematurity in preterm infants","author":"Phelps DL","year":"2001","unstructured":"Phelps DL, Lakatos L, Watts JL. D-Penicillamine for preventing retinopathy of prematurity in preterm infants. Cochrane Database Syst Rev. 2001:CD001073.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.73.1.F27"},{"key":"e_1_3_2_6_2","first-page":"CD000122","article-title":"Early light reduction for preventing retinopathy of prematurity in very low birth weight infants","author":"Phelps DL","year":"2001","unstructured":"Phelps DL, Watts JL. Early light reduction for preventing retinopathy of prematurity in very low birth weight infants. Cochrane Database Syst Rev. 2001:CD000122.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.2.339"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.81.5.697"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00540-1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpa.2001.113843"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20080501-12"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(03)00119-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9066-0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2007.11.008"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0392"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-4-15"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2749"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040030908011"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1684"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.05.023"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"30S","DOI":"10.1002\/j.1875-9114.1990.tb03577.x","article-title":"Pharmacologic activity of ketorolac tromethamine","volume":"10","author":"Rooks WH","year":"1990","unstructured":"Rooks WH. Pharmacologic activity of ketorolac tromethamine. Pharmacotherapy. 1990;10:30S\u201332S.","journal-title":"Pharmacotherapy"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-19991101-10"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)01115-4"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.073817"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079904X16759"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(88)33034-4"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2000.00534.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.09.012"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2009.0126"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.01.017"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4140"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(02)00302-8"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2004.01250.x"}],"container-title":["Journal of Pediatric Ophthalmology &amp; Strabismus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.slackinc.com\/doi\/resolver.asp?doi=10.3928\/01913913-20100920-01","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T16:39:27Z","timestamp":1711816767000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01913913-20100920-01"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.3928\/01913913-20100920-01"],"URL":"https:\/\/doi.org\/10.3928\/01913913-20100920-01","relation":{},"ISSN":["0191-3913","1938-2405"],"issn-type":[{"value":"0191-3913","type":"print"},{"value":"1938-2405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}