{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:21:12Z","timestamp":1791584472750,"version":"4.3.4"},"reference-count":53,"publisher":"SLACK, Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Ophthalmol Strabismus"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To explore the effect of resveratrol on B-cell leukemia\/lymphoma-2 (Bcl-2) and vascular endothelial growth factor (VEGF) expression in rats with oxygen-induced retinopathy of prematurity (ROP).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Seven-day-old Sprague-Dawley rats (N = 60) were randomly assigned to five groups. Group A received normal partial oxygen pressure and groups B, C, D, and E received 75% \u00b1 2% oxygen for 5 days to induce ROP. The rats in groups C, D, and E were intragastrically treated with resveratrol (10, 30, and 60 mg\/kg\/d, respectively) once daily for 5 days. Rats were killed at 17 days of age and the retina was collected.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Western blot analysis revealed increased Bcl-2 protein expression in group B versus group A. Levels of Bcl-2 decreased with the increase of resveratrol concentration in groups C, D, and E. The optical density of Bcl-2 protein expression in group B was four times higher than that in group A (\n              <jats:italic>P<\/jats:italic>\n              &lt; .01). When compared with group B, expression of Bcl-2 and VEGF in groups C, D, and E decreased in a dose-dependent manner. Significant differences in expression of Bcl-2 and VEGF were also noted among the three treatment groups with resveratrol (\n              <jats:italic>P<\/jats:italic>\n              &lt; .01). After treatment with resveratrol at 10, 30, and 60 mg\/kg\/d, the inhibition rate of Bcl-2 expression was 11.1%, 38.1%, and 69.8% and that of VEGF expression was 3.4%, 23.0%, and 43.7%, respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Resveratrol can significantly inhibit expression of Bcl-2 and VEGF in the retina of neonatal rats with oxygen-induced ROP. It may provide a protective effect on retinal neovascular diseases, including ROP.<\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/01913913-20111129-01","type":"journal-article","created":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T14:06:43Z","timestamp":1323439603000},"page":"230-235","source":"Crossref","is-referenced-by-count":18,"title":["Effect of Resveratrol on Bcl-2 and VEGF Expression in Oxygen-Induced Retinopathy of Prematurity"],"prefix":"10.3928","volume":"49","author":[{"given":"Wenlin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1180"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fml071"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9066-0"},{"key":"e_1_3_2_6_2","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith LE","year":"1994","unstructured":"Smith LE, Wesolowski E, McLellan A, et al. 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