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There has been a trend in the scientific literature of the past 2 years toward larger, multi-center, randomized studies investigating the role of bevacizumab in the treatment of ROP. More recent evidence suggests that monotherapy with intravitreal bevacizumab may be a viable first-line treatment for select cases of zone I ROP and possibly for posterior zone II disease. Adjunctive treatment with bevacizumab may enhance outcomes in patients treated with laser photocoagulation or pars plana vitrectomy. However, there are significant concerns regarding its long-term safety profile. Further prospective studies are warranted to more fully determine the role of anti-VEGF therapy in this disease.<\/jats:p>","DOI":"10.3928\/01913913-20120821-03","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T19:29:20Z","timestamp":1346527760000},"page":"332-340","source":"Crossref","is-referenced-by-count":17,"title":["An Evidence-Based Meta-analysis of Vascular Endothelial Growth Factor Inhibition in Pediatric Retinal Diseases: Part 1. 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