{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:20:18Z","timestamp":1773922818070,"version":"3.50.1"},"reference-count":34,"publisher":"SLACK, Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Ophthalmol Strabismus"],"published-print":{"date-parts":[[2015,5]]},"abstract":"\n Purpose:<\/jats:title>\n To investigate the clinical and macular spectral-domain optical coherence tomography (SD-OCT) findings after intravitreal ranibizumab treatment for type 1 retinopathy of prematurity (ROP).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Eighteen eyes of 10 premature infants with type 1 ROP were retrospectively studied. All eyes were treated with intravitreal ranibizumab as monotherapy. Macular SD-OCT was performed before and after intravitreal ranibizumab therapy using a portable SD-OCT machine; the follow-up images were taken 1 day, 1 week, 1 month, and 2 months after therapy.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Among the 10 infants, there were six males and four females. Mean central foveal thickness before and 2 months after intravitreal ranibizumab was 292.5 \u00b1 61.4 and 171.6 \u00b1 21.7 \u00b5m, respectively. Differences were statistically significant (\n P<\/jats:italic>\n = .01). Sixteen eyes of eight patients had macular edema before treatment. Two eyes of two patients developed a crack in the outer hyperreflective line on SD-OCT corresponding with retinal pigment epithelium with serous retinal detachment 1 day after treatment. Macular edema regressed in all patients 2 months after intravitreal ranibizumab therapy. Mean follow-up time was 11.4 \u00b1 1.5 months. No recurrence was seen except in both eyes of one patient treated with intravitreal ranibizumab monotherapy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Intravitreal ranibizumab injection is effective for the treatment of type 1 ROP as a monotherapy agent; however, macular changes not seen with indirect ophthalmoscope may develop.<\/jats:p>\n \n \n [\n J Pediatr Ophthalmol Strabismus.<\/jats:italic>\n 2015;52(3):152\u2013158.]\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3928\/01913913-20150326-12","type":"journal-article","created":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T16:37:35Z","timestamp":1433781455000},"page":"152-158","source":"Crossref","is-referenced-by-count":11,"title":["Spectral-Domain OCT Analyses of Macular Changes After Ranibizumab Therapy for Type 1 Retinopathy of Prematurity"],"prefix":"10.3928","volume":"52","author":[{"given":"Muhammet Kazim","family":"Erol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz Turgut","family":"Coban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zdemir","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuhal \u00d6zen","family":"Tunay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Burak","family":"Bilgin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berna","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9066-0"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140410008"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090030057039"},{"key":"e_1_3_1_5_2","first-page":"290","article-title":"Roles of endothelial growth factor and astrocyte degeneration in the genesis of retinopathy of prematurity","volume":"37","author":"Stone J","year":"1996","unstructured":"Stone J, Chang-Ling T, Pe\u2019er J, Itin A, Gnessin H, Keshet E. 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