{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:09:46Z","timestamp":1775675386132,"version":"3.50.1"},"reference-count":12,"publisher":"SLACK, Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Ophthalmol Strabismus"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Purpose:<\/jats:title>\n To assess the prevalence, incidence, and risk factors for the development of glaucoma in patients with aniridia.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Retrospective analysis of case records of patients diagnosed as having congenital aniridia between January 1986 and December 2011 was performed. Patients with a follow-up of more than 12 months were included.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Ninety-one patients (180 eyes) with the diagnosis of aniridia were identified from the case records. Two eyes were excluded from the final analysis; one had developed phthisis and the other had been enucleated. Seventy-four patients (81.3%) were younger than 18 years at initial presentation. The prevalence of glaucoma at presentation was 28.8%, which could be further categorized as ocular hypertension in 19 eyes (10.5%) and glaucoma in 33 eyes (18.3%). Thirty-one eyes (28.4%) developed elevated intraocular pressure (IOP) during the follow-up period: ocular hypertension in 23 eyes (17.9%) and glaucoma in 8 eyes (6.25%). The mean IOP at the time of diagnosis was 33.9 \u00b1 8.6 mm Hg (range: 24 to 60 mm Hg). The mean duration of follow-up was 8.1 \u00b1 5.7 years (range: 1 to 28 years). The cumulative probability of developing elevated IOP was 4% at the end of 8 years of follow-up; this increased to 88% at the end of 28 years of follow-up. Univariate logistic regression analysis identified higher baseline IOP (odds ratio [OR]: 1.2; 95% confidence interval [CI]: 1.2 to 1.4) and limbal stem cell deficiency (OR: 2.8; 95% CI: 1.4 to 5.6) as significant risk factors for the development of elevated IOP. Higher baseline IOP remained significant on multivariate analysis (OR: 1.2; 95% CI: 1.2 to 1.4).<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Glaucoma occurs in a substantial proportion of patients with aniridia. Eyes with increased IOP at baseline are at a higher risk.<\/jats:p>\n \n \n [\n J Pediatr Ophthalmol Strabismus<\/jats:italic>\n . 2017;54(4):250\u2013255.]\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3928\/01913913-20170322-01","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T19:16:56Z","timestamp":1494962216000},"page":"250-255","source":"Crossref","is-referenced-by-count":15,"title":["Prevalence, Incidence, and Risk Factors for the Development of Glaucoma in Patients With Aniridia"],"prefix":"10.3928","volume":"54","author":[{"given":"Shantha","family":"Balekudaru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandhini","family":"Sankaranarayanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumita","family":"Agarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(84)90184-X"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20131223-01"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-4182(04)80028-0"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(74)90308-0"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2003.09.038"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181d20493"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01427.x"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/09286580701501931"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000019"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-301684"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.12.1819"},{"key":"e_1_3_1_13_2","first-page":"233","volume-title":"Childhood Glaucoma: The 9th Consensus Report of the World Glaucoma Association","author":"Fenerty C","year":"2013","unstructured":"Fenerty C, Freeman N, Grigg J. Glaucoma following cataract surgery. In , Weinreb RN, Grajewski AL, Papadopoulos M, Grigg J, Freedman S, eds. Childhood Glaucoma: The 9th Consensus Report of the World Glaucoma Association. Amsterdam: Kugler Publications; 2013:233\u2013247."}],"container-title":["Journal of Pediatric Ophthalmology & Strabismus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/01913913-20170322-01","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T07:23:35Z","timestamp":1683098615000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01913913-20170322-01"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.3928\/01913913-20170322-01"],"URL":"https:\/\/doi.org\/10.3928\/01913913-20170322-01","relation":{},"ISSN":["0191-3913","1938-2405"],"issn-type":[{"value":"0191-3913","type":"print"},{"value":"1938-2405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}