{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:20:15Z","timestamp":1778948415894,"version":"3.51.4"},"reference-count":13,"publisher":"SLACK, Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Ophthalmol Strabismus"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>\n            The authors describe a case of presumed endogenous fungal endophthalmitis in an immunocompetent pediatric patient with acute lymphoblastic leukemia. A 15-year-old boy with a history of high-risk B-cell acute lymphoblastic leukemia status post-chemotherapy presented with acute changes in vision in his left eye. Fundus examination revealed a white bi-lobed chorioretinal lesion with overlying vitritis and associated subretinal fluid. Magnetic resonance imaging of the brain revealed small ring-enhancing lesions in the right parietal and left occipital lobes. Blood, cerebrospinal fluid, aqueous, and vitreous cultures were all negative. Bone marrow and vitreous cytology were negative for malignant cells. The patient was treated for presumed fungal endophthalmitis with systemic and intravitreal voriconazole, followed by pars plana vitrectomy with intravitreal voriconazole and amphotericin B injections. The chorioretinal lesion resolved and visual acuity recovered to 20\/20. Chorioretinal infiltrates in a patient with leukemia may require treatment even in the absence of a definitive diagnostic test result. Intervention should be guided by risk analysis and clinical judgment.\n            <jats:bold>\n              [\n              <jats:italic>J Pediatr Ophthalmol Strabismus.<\/jats:italic>\n              2017;54:e42\u2013e46.]\n            <\/jats:bold>\n          <\/jats:p>","DOI":"10.3928\/01913913-20170531-08","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T13:44:19Z","timestamp":1498830259000},"source":"Crossref","is-referenced-by-count":1,"title":["Management of Presumed Endogenous Fungal Endophthalmitis in a Child With Acute Lymphoblastic Leukemia"],"prefix":"10.3928","volume":"54","author":[{"given":"Katherine E.","family":"Uyhazi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton M.","family":"Kolomeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iga N.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Traband","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita A.","family":"Kohli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan M.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert M.","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1869-5760-3-60"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000321"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31822d3a34"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00817-X"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.056"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199806000-00012"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12348-015-0054-z"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000238"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.4.4.675"},{"key":"e_1_3_1_11_2","first-page":"1","article-title":"Outcomes of primary transconjunctival 23-gauge vitrectomy in the diagnosis and treatment of presumed endogenous fungal endophthalmitis","author":"William A","year":"2016","unstructured":"William A, Spitzer MS, Deuter C, et al. Outcomes of primary transconjunctival 23-gauge vitrectomy in the diagnosis and treatment of presumed endogenous fungal endophthalmitis. Ocul Immunol Inflamm. 2016:1\u20137.","journal-title":"Ocul Immunol Inflamm"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.10.2643-2646.1995"},{"key":"e_1_3_1_13_2","first-page":"167","article-title":"Comparison of microbiology and visual outcomes of patients undergoing small-gauge and 20-gauge vitrectomy for endophthalmitis","volume":"10","author":"Almeida DR","year":"2016","unstructured":"Almeida DR, Chin EK, Shah SS, et al. Comparison of microbiology and visual outcomes of patients undergoing small-gauge and 20-gauge vitrectomy for endophthalmitis. Clin Ophthalmol. 2016;10:167\u2013172.","journal-title":"Clin Ophthalmol"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-11-30"}],"container-title":["Journal of Pediatric Ophthalmology &amp; Strabismus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/01913913-20170531-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T23:18:03Z","timestamp":1683069483000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01913913-20170531-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.3928\/01913913-20170531-08"],"URL":"https:\/\/doi.org\/10.3928\/01913913-20170531-08","relation":{},"ISSN":["0191-3913","1938-2405"],"issn-type":[{"value":"0191-3913","type":"print"},{"value":"1938-2405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}