{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T04:38:38Z","timestamp":1794285518902,"version":"4.9.0"},"reference-count":26,"publisher":"SLACK, Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Ophthalmol Strabismus"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To compare the effect of two exposure durations of mitomycin C in combined angle and filtering surgery for primary congenital glaucoma.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This was a prospective study conducted in the Department of Ophthalmology at Alexandria Main University Hospital, Alexandria, Egypt, on 75 eyes with primary congenital glaucoma that underwent combined trabeculotomy\u2013trabeculectomy with intraoperative mitomycin C application for 1 minute (MMC 1) or 2 minutes (MMC 2) and were followed up for 24 months. Success rates were studied and complications noted. Success was defined by a composite primary end point of an intraocular pressure (IOP) of less than 16 mm Hg under general anesthesia, without any IOP-lowering medications and with no hypotony-related complications and\/or lack of IOP-related progression of the disease as evidenced by worsening of the ocular biometric characteristics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>The mean age of the study participants was 6.7 \u00b1 4.1 months (range: 2 to 16 months; median: 6 months) in the MMC 1 group (35 eyes) and 7.7 \u00b1 5.7 months (range: 1 to 32 months; median: 6.5 months) in the MMC 2 group (40 eyes). The initial surgery was successful in 32 (91.5%) and 31 (77.5%) eyes in the MMC 1 and MMC 2 groups, respectively. The mean IOP was 18.4 \u00b1 5.1 and 18.1 \u00b1 6.1 mm Hg preoperatively and 5.5 \u00b1 3.5 and 4.8 \u00b1 2.8 mm Hg at the end of follow-up in the MMC 1 and MMC 2 groups, respectively. There was no statistically significant difference in the clinical parameters between the two groups. Complications included cataracts in each group and hypotony optic disc edema in 3 eyes (7.5%) in the MMC 2 group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Both mitomycin C application durations were effective in combined trabeculotomy\u2013trabeculectomy with mitomycin C for primary congenital glaucoma. The longer duration was not advantageous in disease control and there were no significant differences in complications.<\/jats:p>\n            <jats:p>\n              <jats:bold>\n                [\n                <jats:italic>J Pediatr Ophthalmol Strabismus<\/jats:italic>\n                . 2018;55(3):164\u2013170.]\n              <\/jats:bold>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/01913913-20171129-02","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T16:00:14Z","timestamp":1517414414000},"page":"164-170","source":"Crossref","is-referenced-by-count":7,"title":["Mitomycin C in Filtering Surgery for Primary Congenital Glaucoma: A Comparison of Exposure Durations"],"prefix":"10.3928","volume":"55","author":[{"given":"Nader H.","family":"Bayoumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","first-page":"6","volume-title":"Childhood Glaucoma: WGC Consensus 9","author":"Weinreb RN","year":"2013","unstructured":"Weinreb RN, Grajewski AL, Papadopoulos M, Grigg J, Freedman S. Childhood Glaucoma: WGC Consensus 9. 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Combined trabeculotomy and augmented trabeculectomy in primary congenital glaucoma. J Coll Physicians Surg Pak. 2013;23:116\u2013119.","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.126988"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20120710-06"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34803-4"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.07.030"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-016-0415-z"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-8531(99)70082-0"}],"container-title":["Journal of Pediatric Ophthalmology &amp; Strabismus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/01913913-20171129-02","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T02:15:36Z","timestamp":1683080136000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01913913-20171129-02"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.3928\/01913913-20171129-02"],"URL":"https:\/\/doi.org\/10.3928\/01913913-20171129-02","relation":{},"ISSN":["0191-3913","1938-2405"],"issn-type":[{"value":"0191-3913","type":"print"},{"value":"1938-2405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}