{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:01:59Z","timestamp":1791932519020,"version":"4.3.4"},"reference-count":14,"publisher":"SLACK, Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Ophthalmol Strabismus"],"published-print":{"date-parts":[[2019,7]]},"abstract":"\n Purpose:<\/jats:title>\n To investigate persistent avascular retina in infants with type 2 retinopathy of permaturity (ROP) that persisted after 45 weeks' post-menstrual age when regular ROP screening ceased.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A prospective observational study where fundus fluorescein angiography (FFA) was completed on consecutive infants who had a history of type 2 ROP and avascular retina during ROP screening that persisted after 45 weeks' post-menstrual age.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n FFA was completed on 72 eyes of 36 infants (53% male), with a mean gestational age of 26.0 \u00b1 2.2 weeks and a mean birth weight of 834.6 \u00b1 216.3 grams. The mean age at discharge from ROP screening was 47.6 weeks' post-menstrual age. All patients had type 2 ROP at the worst stage of their disease, with predominantly stage 2 disease. FFA was performed at a mean age of 18.8 \u00b1 10.3 months post-menstrual age. All patients had detectable avascular retina in peripheral zone II or III on FFA. Peripheral vessel leakage was present in 3 eyes of 2 infants (5.5%), who both subsequently received peripheral laser treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Premature infants with type 2 ROP may have persistent peripheral avascular retina with unknown long-term ocular complications, which can present management dilemmas. Retinal FFA is recommended to determine retinal ischemia and aid decision making for treatment in these cases.<\/jats:p>\n \n \n [\n J Pediatr Ophthalmol Strabismus<\/jats:italic>\n . 2019;56(4):222\u2013228.]\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3928\/01913913-20190501-01","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T12:40:44Z","timestamp":1563540044000},"page":"222-228","source":"Crossref","is-referenced-by-count":24,"title":["Persistent Avascular Retina in Infants With a History of Type 2 Retinopathy of Prematurity: To Treat or Not to Treat?"],"prefix":"10.3928","volume":"56","author":[{"given":"Rasha","family":"Al-Taie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha K.","family":"Simkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Dou\u00e7et","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040030908011"},{"key":"e_1_3_1_3_2","first-page":"233","article-title":"Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial","volume":"102","author":"Good WV","year":"2004","unstructured":"Good WVEarly Treatment for Retinopathy of Prematurity Cooperative Group. Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial. Trans Am Ophthalmol Soc. 2004;102:233\u2013248.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.3.311"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12940"},{"key":"e_1_3_1_7_2","first-page":"73","article-title":"Plus disease in retinopathy of prematurity: an analysis of diagnostic performance","volume":"105","author":"Chiang MF","year":"2007","unstructured":"Chiang MF, Gelman R, Jiang L, et al. Plus disease in retinopathy of prematurity: an analysis of diagnostic performance. Trans Am Ophthalmol Soc. 2007;105:73\u201384.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-2996"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31301-7"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20180803-11"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31820d3f70"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.04.021"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304109"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14187"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20180628-05"}],"container-title":["Journal of Pediatric Ophthalmology & Strabismus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/01913913-20190501-01","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T21:48:03Z","timestamp":1683064083000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01913913-20190501-01"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.3928\/01913913-20190501-01"],"URL":"https:\/\/doi.org\/10.3928\/01913913-20190501-01","relation":{},"ISSN":["0191-3913","1938-2405"],"issn-type":[{"value":"0191-3913","type":"print"},{"value":"1938-2405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}