{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:53:32Z","timestamp":1793332412688,"version":"4.5.0"},"reference-count":12,"publisher":"SLACK, Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Ophthalmol Strabismus"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n            <jats:title>Purpose:<\/jats:title>\n            <jats:p>To investigate the clinical and histopathological features of congenital fibrovascular pupillary membrane (CFPM) in Chinese patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This retrospective study reviewed CFPM cases treated at Beijing Children's Hospital. The clinical manifestations, approaches of treatment, outcomes, and histopathological findings were collected and analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A total of 33 patients with CFPM were reviewed. All patients had unilateral eye involvement. A total of 21 eyes (63.64%) had a white membrane that partially covered the pupil and 12 eyes (36.36%) had a membrane that completely covered the pupil. Of the 12 eyes with a complete pupillary membrane, 6 (50%) had glaucoma. For eyes with a partial pupillary membrane, 11 eyes (52.38%) were followed up at the outpatient clinic without surgery and 10 eyes (47.62%) underwent membranectomy and pupilloplasty due to visual axis blockage. For the 12 eyes with a complete pupillary membrane, 6 eyes (50%) with normal intraocular pressure (IOP) received membranectomy and pupilloplasty combined with iridectomy, and 1 (16.67%) of these 6 eyes underwent a reoperation after 5 months due to a recurrent membrane. Furthermore, 6 eyes (50%) with glaucoma had membranectomy, pupilloplasty, iridectomy, and goniosynechialysis. Among these 6 eyes, 2 eyes (33.33%) underwent a reoperation due to the recurrence of a membrane and 4 eyes (66.67%) had a pale optic disc. The histopathological findings revealed that these membranes were mainly composed of fibrous tissue, lymphocytes, pigment epithelial cells, and vascular tissues.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>CFPM has diverse manifestations, including a partial pupillary membrane, a complete pupillary membrane with normal IOP, and a complete pupillary membrane with glaucoma. Timely diagnosis and treatment are critical when the visual axis is blocked and\/or the IOP is high.<\/jats:p>\n            <jats:p>\n              <jats:bold>\n                [\n                <jats:italic>J Pediatr Ophthalmol Strabismus<\/jats:italic>\n                . 2021;58(2):105\u2013111.]\n              <\/jats:bold>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/01913913-20201230-01","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T07:52:36Z","timestamp":1619077956000},"page":"105-111","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and Histopathological Features of Congenital Fibrovascular Pupillary Membranes in a Chinese Case Series"],"prefix":"10.3928","volume":"58","author":[{"given":"Tianwei","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.3928\/1542-8877-19940901-06"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.08.043"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(86)33659-5"},{"key":"e_1_3_1_5_2","first-page":"45","article-title":"Fibrous congenital iris membranes with pupillary distortion","volume":"99","author":"Robb RM","year":"2001","unstructured":"Robb RM. Fibrous congenital iris membranes with pupillary distortion. Trans Am Ophthalmol Soc. 2001;99:45\u201350.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2004.04.010"},{"issue":"2","key":"e_1_3_1_7_2","first-page":"80","article-title":"The study of grading standard photos of oblique flashlight test [article in Chinese]","volume":"11","author":"Yu Q","year":"1995","unstructured":"Yu Q, Li S, Ye T. The study of grading standard photos of oblique flashlight test [article in Chinese]. Yan Ke Xue Bao. 1995;11(2):80\u201385.","journal-title":"Yan Ke Xue Bao"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1957.00940010526005"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2009.09.010"},{"key":"e_1_3_1_10_2","first-page":"139","article-title":"Bilateral congenital persistent pupillary membranes","volume":"52","author":"Zhao Y","year":"2016","unstructured":"Zhao Y, Song GX, Zhao H. Bilateral congenital persistent pupillary membranes. Chinese Journal of Ophthalmology. 2016;52:139.","journal-title":"Chinese Journal of Ophthalmology"},{"key":"e_1_3_1_11_2","first-page":"1038","article-title":"Congenital persistent pupillary membrane","volume":"49","author":"Dang GF","year":"2013","unstructured":"Dang GF. Congenital persistent pupillary membrane. Chinese Journal of Ophthalmology. 2013;49:1038.","journal-title":"Chinese Journal of Ophthalmology"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_495_18"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.5693\/djo.02.2011.10.001"}],"container-title":["Journal of Pediatric Ophthalmology &amp; Strabismus"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T10:33:06Z","timestamp":1683109986000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/01913913-20201230-01"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.3928\/01913913-20201230-01"],"URL":"https:\/\/doi.org\/10.3928\/01913913-20201230-01","relation":{},"ISSN":["0191-3913","1938-2405"],"issn-type":[{"value":"0191-3913","type":"print"},{"value":"1938-2405","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3]]}}}