{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:00:40Z","timestamp":1768284040809,"version":"3.49.0"},"reference-count":15,"publisher":"SLACK, Inc.","issue":"S2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[2008,9]]},"abstract":"\n Purpose<\/jats:title>\n To evaluate the safety and efficacy of staged ultraviolet A (UVA) cross-linking following intrastromal 0.1% riboflavin administration in eyes with advanced corneal edema.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Ten eye bank corneas divided in two groups (n=5) were placed on a pressurized artificial anterior chamber following Descemet's membrane stripping. Two consecutive corneal pockets (350- and 150-\u00b5m depth) were sequentially created using a femtosecond laser. Sequential intrastromal injections of 0.1% riboflavin (0.2 mL) followed by either UVA irradiation (15 mW\/cm\n 2<\/jats:sup>\n ) for 7 minutes or exposure to air were performed for each pocket. Corneal clarity and central thickness were measured before and after the two UVA cross-linking steps. The same steps were clinically applied in an 84-year-old woman with bullous keratopathy prior to corneal transplantation and followed for 6 months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The corneal clarity improved in the treated but not the control eyes. The mean central corneal thickness was significantly reduced by 256 \u00b5m (ultrasound,\n P<\/jats:italic>\n =.0002) and 273 \u00b5m (Scheimpflug,\n P<\/jats:italic>\n =.0004) in treated eyes, but only 100 \u00b5m (ultrasound,\n P<\/jats:italic>\n =.048) and 107 \u00b5m (Scheimpflug,\n P<\/jats:italic>\n =.075) in the control eyes. The clinical treatment of corneal edema showed improved clarity and reduced central corneal thickness from 675 to 550 \u00b5m (ultrasound) and 696 to 571 \u00b5m (Scheimpflug) at 1 month. Best spectacle-corrected visual acuity improved from finger counting to 20\/80 at 1 week and beyond, postponing corneal transplantation for >6 months.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Staged UVA cross-linking (15 mW\/cm\n 2<\/jats:sup>\n ) with femtosecond laser facilitated intrastromal 0.1% riboflavin administration may be a safe (no corneal scarring) and effective (marked reduction of edema) temporizing alternative method for managing bullous keratopathy. [\n J Refract Surg<\/jats:italic>\n . 2008;24:S730\u2013S736.]\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3928\/1081597x-20080901-17","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T20:11:46Z","timestamp":1555013506000},"source":"Crossref","is-referenced-by-count":45,"title":["Staged Intrastromal Delivery of Riboflavin With UVA Cross-linking in Advanced Bullous Keratopathy: Laboratory Investigation and First Clinical Case"],"prefix":"10.3928","volume":"24","author":[{"given":"Ronald R.","family":"Krueger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome C.","family":"Ramos-Esteban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. John","family":"Kanellopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34168-9"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1981.03930010417002"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3180544902"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067210601600405"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.01.091"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318074e424"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.07.028"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.03.041"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680490513182"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00447.x"},{"key":"e_1_3_1_13_2","article-title":"Biomechanical effect of intraocular pressure elevation on optic nerve\/lamina cribrosa before and after peripapillary scleral collagen crosslinking","author":"Thornton IL","unstructured":"Thornton IL, Dupps WJ, Krueger RR. Biomechanical effect of intraocular pressure elevation on optic nerve\/lamina cribrosa before and after peripapillary scleral collagen crosslinking. Invest Ophthalmol Vis Sci. In press.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.11.015"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2007.01536.x"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3180334f78"}],"container-title":["Journal of Refractive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/ophthalmology\/refractive-surgery\/journals\/jrs\/2008-9-24-7\/%7Bea06c665-3c54-42b7-8d47-2e596d6f7b6c%7D\/staged-intrastromal-delivery-of-riboflavin-with-uva-cross-linking-in-advanced-bullous-keratopathy-laboratory-investigation-and-first-clinical-case","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T17:17:22Z","timestamp":1731691042000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/1081597X-20080901-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":15,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.3928\/1081597X-20080901-17"],"URL":"https:\/\/doi.org\/10.3928\/1081597x-20080901-17","relation":{},"ISSN":["1081-597X"],"issn-type":[{"value":"1081-597X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}