{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:36:43Z","timestamp":1794019003667,"version":"4.8.0"},"reference-count":20,"publisher":"SLACK, Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE:<\/jats:title>\n                    <jats:p>To evaluate 1-year visual and topographic outcomes and safety and efficacy of corneal collagen cross-linking (CXL) combined with topography-guided photorefractive keratectomy (TG-PRK) to achieve near emmetropia in eyes with low-grade keratoconus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Twenty-two eyes from 15 patients (11 women, 4 men) were included in a prospective, nonrandomized, noncontrolled clinical study. Mean patient age was 26.6\u00b16.07 years (range: 19 to 40 years). Inclusion criteria were low-grade keratoconus with evidence of progression, transparent cornea, corrected distance visual acuity (CDVA) 0.8 (decimal) or better, corneal thickness &gt;440 \u03bcm, and maximum keratometry readings (K-max) &lt;51.00 diopters (D). All patients underwent simultaneous TG-PRK with CXL. Study parameters were uncorrected distance visual acuity, CDVA, manifest refractive error, manifest and topographic (corneal) astigmatism, patient satisfaction, and efficacy and safety of the treatment. Follow-up was 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      After 1 year, statistically significant improvement was noted in all study parameters (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;.01). The safety and efficacy indices were 1.6 and 0.4, respectively. Patient satisfaction questionnaire showed that 91% were satisfied, 9% were not completely satisfied but believed they improved, and none were dissatisfied. Corneal topography demonstrated significant improvement in 55%, improvement in 36%, and minor improvement in 9% of cases. No cases progressed as evidenced by keratometry readings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Simultaneous TG-PRK with CXL is an effective and safe treatment with remarkable visual and topographic outcomes in patients with low-grade keratoconus who meet the recommended inclusion criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3928\/1081597x-20120316-01","type":"journal-article","created":{"date-parts":[[2012,3,25]],"date-time":"2012-03-25T13:48:53Z","timestamp":1332683333000},"page":"341-347","source":"Crossref","is-referenced-by-count":60,"title":["Safety and Efficacy of Simultaneous Corneal Collagen Cross-linking With Topography-guided PRK in Managing Low-grade Keratoconus: 1-year Follow-up"],"prefix":"10.3928","volume":"28","author":[{"given":"Waleed S.","family":"Tuwairqi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen M.","family":"Sinjab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20110705-01"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20110906-03"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2004.10.042"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20101223-02"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20110203-01"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100212-09"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.07.028"},{"key":"e_1_3_2_10_2","first-page":"11","article-title":"Management of post laser in situ keratomileusis ectasia with simultaneous topography guided photorefractive keratectomy and collagen cross-linking","volume":"5","author":"Kymionis GD","year":"2011","unstructured":"Kymionis GD, Portaliou DM, Diakonis VF, et al. Management of post laser in situ keratomileusis ectasia with simultaneous topography guided photorefractive keratectomy and collagen cross-linking. 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