{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:34:30Z","timestamp":1793406870769,"version":"4.5.0"},"reference-count":20,"publisher":"SLACK, Inc.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE:<\/jats:title>\n            <jats:p>To describe and quantify the errors inherent to topography-guided ablation of irregular corneas due to natural epithelial thickness compensatory remodeling.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Artemis very high-frequency (VHF) digital ultrasound scanning (ArcScan Inc) was performed on a cornea that had undergone radial keratotomy with inferior and superior trapezoidal keratotomies, resulting 27 years later in high irregular astigmatism (+6.50 \u22128.00 \u00d7 101) and severe loss of corrected distance visual acuity (CDVA) to 20\/50. The epithelial thickness profile was highly irregular, masking a significant proportion of the true stromal irregularity from front corneal surface topography, which would have resulted in significant inaccuracies had a topography-guided ablation been performed. The stromal ablation pattern of a transepithelial phototherapeutic keratectomy (PTK) ablation was modeled, which appeared logically to reduce the areas of abnormal stromal surface elevation and resembled a hyperopic astigmatic ablation of approximately 3.50 diopters of cylinder. Artemis-assisted transepithelial PTK was performed to target the stromal irregularity masked by epithelium.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Artemis-assisted transepithelial PTK induced a refractive change similar to that predicted (+2.24 \u22123.97 \u00d7 120), demonstrating the refractive shift produced by the epithelium. The epithelial thickness profile became relatively regular and CDVA returned to 20\/20\n              <jats:sup>\u22122<\/jats:sup>\n              . Two topography wavefront-guided ablations were performed to correct the remaining topographic irregularity and refractive error, resulting in a near plano refraction, significantly lower higher order aberrations, and CDVA of 20\/20\n              <jats:sup>+2<\/jats:sup>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>A knowledge of stromal surface shape and power shift produced by epithelial thickness profile alterations after corneal surgery has the potential of improving the efficacy and safety of custom corneal ablation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/1081597x-20120815-02","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T13:56:52Z","timestamp":1346767012000},"page":"657-663","source":"Crossref","is-referenced-by-count":66,"title":["Refractive and Topographic Errors in Topography-guided Ablation Produced by Epithelial Compensation Predicted by 3D Artemis VHF Digital Ultrasound Stromal and Epithelial Thickness Mapping"],"prefix":"10.3928","volume":"28","author":[{"given":"Dan Z.","family":"Reinstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Archer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Gobbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","volume-title":"Textbook and Atlas of Slit Lamp Microscopy of the Living Eye","author":"Vogt A","year":"1981","unstructured":"Vogt A. Textbook and Atlas of Slit Lamp Microscopy of the Living Eye. Bonn, Germany: Wayenborgh Editions; 1981."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.07.016"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.6.545"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20090422-07"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20120127-02"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20091105-02"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20110125-01"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90105-7"},{"issue":"4","key":"e_1_3_2_10_2","first-page":"1739","article-title":"Epithelial and corneal 3D ultrasound pachymetric topography post excimer laser surgery","volume":"35","author":"Reinstein DZ","year":"1994","unstructured":"Reinstein DZ, Aslanides IM, Silverman RH, et al. Epithelial and corneal 3D ultrasound pachymetric topography post excimer laser surgery. Invest Ophthalmol Vis Sci. 1994;35(4):1739.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_2_11_2","first-page":"29","volume-title":"Irregular Astigmatism: Diagnosis and Treatment","author":"Reinstein DZ","year":"2007","unstructured":"Reinstein DZ, Archer TJ. Evaluation of irregular astigmatism with Artemis very high-frequency digital ultrasound scanning. In: , Wang M, ed. Irregular Astigmatism: Diagnosis and Treatment. Thorofare, NJ: SLACK Incorporated; 2007:29\u201342."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-20000101-03"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1986.01050220128040"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100212-04"},{"key":"e_1_3_2_15_2","volume-title":"Presented at: Contact Lens Association of Ophthalmologists","author":"Reinstein DZ","unstructured":"Reinstein DZ, Silverman RH, Aslanides IM, Asbell PA, Coleman DJ. Corneal pachymetric topography in the assessment of anterior corneal scars for therapeutic planning. Presented at: Contact Lens Association of Ophthalmologists; January 12\u201315, 1994; Las Vegas, Nevada."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(00)00797-5"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100121-06"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(01)00802-1"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-20050901-23"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20090512-04"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20110926-01"}],"container-title":["Journal of Refractive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/1081597X-20120815-02","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T12:30:42Z","timestamp":1683117042000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/1081597X-20120815-02"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.3928\/1081597X-20120815-02"],"URL":"https:\/\/doi.org\/10.3928\/1081597x-20120815-02","relation":{},"ISSN":["1081-597X"],"issn-type":[{"value":"1081-597X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}