{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T20:54:48Z","timestamp":1776804888741,"version":"3.51.2"},"reference-count":15,"publisher":"SLACK, Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE:<\/jats:title>\n                    <jats:p>To evaluate the outcomes and safety of a refractive inlay (Flexivue Micro-Lens, Presbia Co\u00f6peratief U.A.) for the corneal compensation of presbyopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This prospective, interventional clinical study comprised 47 emmetropic presbyopes with a mean age of 52\u00b14 years (range: 45 to 60 years). The inlay was inserted, centered on the line of sight, inside a corneal pocket created in the patient\u2019s nondominant eye, using a femtosecond laser. Follow-up was 12 months. Visual acuity, corneal topography, wavefront aberrometry, contrast sensitivity, structural corneal alterations, and questionnaires were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Twelve months after surgery, uncorrected near visual acuity was 20\/32 or better in 75% of operated eyes, whereas mean uncorrected distance visual acuity (UDVA) of operated eyes was statistically significantly decreased from 0.06\u00b10.09 logMAR (20\/20) (range: \u22120.08 to 0.26) preoperatively to 0.38\u00b10.15 logMAR (20\/50) (range: 0.12 to 0.8) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;.001), and mean binocular UDVA was not significantly altered (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =.516). Seventeen patients lost one line of corrected distance visual acuity in the operated eye. No patient lost 2 lines in CDVA in the operated eye. Overall, higher order aberrations increased and contrast sensitivity decreased in the operated eye. No tissue alterations were found using corneal confocal microscopy. No intra- or postoperative complications occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Twelve months after implantation, the Flexivue Micro-Lens intracorneal refractive inlay seems to be an effective method for the corneal compensation of presbyopia in emmetropic presbyopes aged between 45 and 60 years old.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3928\/1081597x-20121210-01","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T10:33:10Z","timestamp":1357900390000},"page":"12-19","source":"Crossref","is-referenced-by-count":69,"title":["Visual Outcomes and Safety of a Refractive Corneal Inlay for Presbyopia Using Femtosecond Laser"],"prefix":"10.3928","volume":"29","author":[{"given":"Aliki N.","family":"Limnopoulou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios I.","family":"Bouzoukis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George D.","family":"Kymionis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia I.","family":"Panagopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotiris","family":"Plainis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristophanes I.","family":"Pallikaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Feingold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis G.","family":"Pallikaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.07.015"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.05.019"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100408-01"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.031"},{"key":"e_1_3_2_6_2","first-page":"48","article-title":"Corneal inlays: a surgical correction of presbyopia","volume":"3","author":"Kymionis GD","year":"2007","unstructured":"Kymionis GD, Bouzoukis DI, Pallikaris IG. Corneal inlays: a surgical correction of presbyopia. Cataract & Refractive Surgery Today Europe. 2007;3:48\u201350.","journal-title":"Cataract & Refractive Surgery Today Europe"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20120124-02"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20110706-01"},{"key":"e_1_3_2_9_2","volume-title":"Paper presented at: 28th Annual European Society of Cataract and Refractive Surgery Meeting","author":"Slade S","unstructured":"Slade S. Early results using the presbylens corneal inlay to improve near and intermediate vision in emmetropic presbyopes. Paper presented at: 28th Annual European Society of Cataract and Refractive Surgery Meeting; September 4\u20138, 2010; Paris, France."},{"key":"e_1_3_2_10_2","first-page":"197","volume-title":"Presbyopia: Orgins, Effects, and Treatment","author":"Bouzoukis DI","year":"2012","unstructured":"Bouzoukis DI, Pallikaris IG. Intracorneal inlays for presbyopia. In: , Pallikaris IG, Plainis S, Charman WN, eds. Presbyopia: Orgins, Effects, and Treatment. Throfare, New Jersey: Slack Incorporated; 2012:197\u2013204."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-20050501-07"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-20040901-26"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.03.061"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.08.039"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e31815b9dd6"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20121116-01"}],"container-title":["Journal of Refractive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/1081597X-20121210-01","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T20:06:55Z","timestamp":1776802015000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/1081597X-20121210-01"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1,1]]}},"alternative-id":["10.3928\/1081597X-20121210-01"],"URL":"https:\/\/doi.org\/10.3928\/1081597x-20121210-01","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717989865.793473741","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717989865.793473064","asserted-by":"object"}]},"ISSN":["1081-597X"],"issn-type":[{"value":"1081-597X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1,1]]}}}