{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:22:31Z","timestamp":1780082551679,"version":"3.54.0"},"reference-count":20,"publisher":"SLACK, Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE:<\/jats:title>\n                    <jats:p>To compare the corneal collagen cross-linking (CXL) demarcation line depth between the central and peripheral cornea after cross-linking using anterior segment optical coherence tomography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Retrospective interventional case series of 38 eyes with keratoconus or postoperative LASIK ectasia treated with riboflavin ultraviolet A CXL (UV-X, IROC). CXL demarcation line depth, corneal thickness, and the ratio of the CXL demarcation line depth to the corneal thickness were measured using anterior segment optical coherence tomography at the central cornea and at 2 and 4 mm from the corneal center in four regions: temporal, nasal, superior, and inferior. The CXL demarcation line depths at the center and periphery were compared using the Friedman test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The CXL demarcation line was deepest in the central cornea (302 \u03bcm; range: 180 to 397 \u03bcm) and was reduced progressively toward the peripheral cornea, at nasal 2 mm (289.5 \u03bcm; range: 125 to 370 \u03bcm), at nasal 4 mm (206.5 \u03bcm; range: 100 to 307 \u03bcm), at temporal 2 mm (278.5 \u03bcm; range: 128 to 375 \u03bcm), and at temporal 4 mm (194 \u03bcm; range: 80 to 325 \u03bcm) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;.001). The penetration proportion was greatest at the central cornea (64.8%; range: 44% to 80%) and was decreased toward the periphery, at nasal 2 mm (53.8%; range: 30% to 74%), at nasal 4 mm (33.8%; range: 19% to 53%), at temporal 2 mm (54.1%; range: 29% to 77%), and at temporal 4 mm (34.1%; range: 15% to 54%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2a7d.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Both the CXL demarcation line depth and its proportion over the corneal thickness were greater at the central cornea than the peripheral cornea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3928\/1081597x-20121228-03","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T10:35:04Z","timestamp":1357900504000},"page":"49-53","source":"Crossref","is-referenced-by-count":14,"title":["Reduced Cross-linking Demarcation Line Depth at the Peripheral Cornea After Corneal Collagen Cross-linking"],"prefix":"10.3928","volume":"29","author":[{"given":"Jason C. S.","family":"Yam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur C. K.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.01.091"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.12.039"},{"issue":"7","key":"e_1_3_2_5_2","first-page":"S720","article-title":"A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results","volume":"24","author":"Wittig-Silva C","year":"2008","unstructured":"Wittig-Silva C, Whiting M, Lamoureux E, Lindsay RG, Sullivan LJ, Snibson GR. A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results. J Refract Surg. 2008;24(7):S720\u2013S725.","journal-title":"J Refract Surg"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.11.046"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20090401-02"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.07.030"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.07.028"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20090910-02"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700751"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000225720.38748.58"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.05.042"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.06.031"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.10.021"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2003.09.008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20120518-02"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.03.028"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02228.x"},{"key":"e_1_3_2_20_2","first-page":"120","volume-title":"Anterior Segment Optical Coherence Tomography: Noncontact High Resolution Imaging of the Anterior Chamber. Techniques in Ophthalmology","author":"Lee R","year":"2006","unstructured":"Lee R, Ahmed IK. Anterior Segment Optical Coherence Tomography: Noncontact High Resolution Imaging of the Anterior Chamber. Techniques in Ophthalmology. Philadelphia: Lippincott, Williams and Wilkins; 2006:120\u2013127."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-7105"}],"container-title":["Journal of Refractive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/1081597X-20121228-03","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T20:06:58Z","timestamp":1776802018000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/1081597X-20121228-03"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1,1]]}},"alternative-id":["10.3928\/1081597X-20121228-03"],"URL":"https:\/\/doi.org\/10.3928\/1081597x-20121228-03","relation":{},"ISSN":["1081-597X"],"issn-type":[{"value":"1081-597X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1,1]]}}}