{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T04:36:55Z","timestamp":1794631015884,"version":"4.9.1"},"reference-count":22,"publisher":"SLACK, Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[2014,6,1]]},"abstract":"\n PURPOSE:<\/jats:title>\n To report a novel method of contact lens-assisted corneal cross-linking (CACXL) in eyes with thin corneas.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n Patients diagnosed as having progressive keratectasia with a minimum corneal thickness less than 400 and greater than 350\n \u03bc<\/jats:italic>\n m after epithelial abrasion were included. After epithelial abrasion, the iso-osmolar riboflavin 0.1% in dextran was applied every 3 minutes for 30 minutes. An ultraviolet barrier-free soft contact lens (0.09-mm thickness, 14-mm diameter) soaked in iso-osmolar riboflavin 0.1% for 30 minutes was placed on the cornea. Once the minimum corneal thickness value was confirmed to be greater than 400\n \u03bc<\/jats:italic>\n m, the ultraviolet-A irradiance was started along with instillation of iso-osmolar riboflavin 0.1% in the pre-corneal and pre-contact lens region. Intraoperative minimum corneal thickness changes were recorded with ultrasound pachymetry and optical coherence tomography. Postoperative visual acuity, corneal topography (Orbscan; Bausch & Lomb, Rochester, NY), endothelial cell loss (EM-3000; Tomey, Nagoya, Japan), and stromal demarcation line (Visante; Carl Zeiss Meditec, Jena, Germany) were measured.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Fourteen eyes underwent the procedure. Mean preoperative minimum corneal thickness after epithelial abrasion was 377.2 \u00b1 14.5\n \u03bc<\/jats:italic>\n m (range: 350 to 398\n \u03bc<\/jats:italic>\n m). There was a significant difference in minimum functional corneal thickness (Friedman test,\n P<\/jats:italic>\n = .000) intraoperatively, before epithelial abrasion, after epithelial abrasion, and with contact lens and riboflavin film. Mean minimum functional corneal thickness after the contact lens was 485.1 \u00b1 15.8\n \u03bc<\/jats:italic>\n m (range: 458 to 511\n \u03bc<\/jats:italic>\n m). Mean absolute increase in the minimum corneal thickness along with the contact lens and pre-corneal riboflavin film was 107.9 \u00b1 9.4\n \u03bc<\/jats:italic>\n m (range: 90 to 124\n \u03bc<\/jats:italic>\n m). Mean depth of stromal demarcation line was 252.9 \u00b1 40.8\n \u03bc<\/jats:italic>\n m (range: 208 to 360\n \u03bc<\/jats:italic>\n m). There was no significant endothelial loss (\n P<\/jats:italic>\n = .063) and the corneal topography was stable at the last follow-up (\n P<\/jats:italic>\n = .505).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n CACXL technique was effective and safe in performing cross-linking in corneas less than 400\n \u03bc<\/jats:italic>\n m after epithelial abrasion and appeared effective based on stromal demarcation line depth.\n <\/jats:p>\n \n \n [\n J Refract Surg.<\/jats:italic>\n 2014;30(6):366\u2013372.]\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3928\/1081597x-20140523-01","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T16:52:48Z","timestamp":1403887968000},"page":"366-372","source":"Crossref","is-referenced-by-count":139,"title":["Contact Lens-Assisted Collagen Cross-Linking (CACXL): A New Technique for Cross-Linking Thin Corneas"],"prefix":"10.3928","volume":"30","author":[{"given":"Soosan","family":"Jacob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhivya Ashok","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushanth","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratheek","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashvin","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0410"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(03)00407-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3180334f78"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000233954.86723.25"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-9-10"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.10.060"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2011.08.030"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700751"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.07.044"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S37335"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.17.11.1058.5233"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.5.619"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.09.010"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31828733ea"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000225720.38748.58"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.06.031"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318030df5a"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.01.009"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.09.048"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2004.00369.x"},{"key":"e_1_3_2_23_2","first-page":"2165","article-title":"UV absorbance of the human cornea in the 240- to 400-nm range","volume":"43","author":"Kolozsvari L","year":"2002","unstructured":"Kolozsvari L, Nogradi A, Hopp B, Bor Z. 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