{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:37:17Z","timestamp":1794019037022,"version":"4.8.0"},"reference-count":40,"publisher":"SLACK, Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE:<\/jats:title>\n                    <jats:p>To describe a new technique for the treatment of keratoconus using corneal allogenic intrastromal ring segments (CAIRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>CAIRS trephined from donor cornea using a double-bladed trephine were implanted into mid-depth femtosecond laser\u2013dissected channels in the cornea of patients with keratoconus in the 6.5-mm optic zone, followed by accelerated corneal cross-linking (A-CXL)\u2014either conventional or contact lens\u2013assisted CXL (A-CACXL), depending on minimum corneal thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Twenty patients (24 eyes) with stage 1 to 4 keratoconus (Amsler\u2013Krumeich grading) were included. Mean follow-up was 11.58 \u00b1 3.6 months (range: 6 to 18 months). There was significant improvement in uncorrected (2.79 \u00b1 2.65 lines; range: 0 to 8 lines) and corrected (1.29 \u00b1 1.33 lines; range: 0 to 5 lines) distance visual acuity, spherical equivalent, simulated maximum keratometry, steepest keratometry, topographic astigmatism, anterior and posterior best fit spheres, and mean power in the 3- and 5-mm zones. No eye showed progression during the entire follow-up. All segments remained well positioned and no segment-induced complications were seen. No other major intraoperative or postoperative complications were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>This pilot study indicates that CAIRS with CXL may be a simple, safe, and effective option for treating keratoconus. Further studies are recommended to determine long-term outcomes.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        [\n                        <jats:italic>J Refract Surg.<\/jats:italic>\n                        2018;34(5):296\u2013303.]\n                      <\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3928\/1081597x-20180223-01","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T14:19:01Z","timestamp":1525789141000},"page":"296-303","source":"Crossref","is-referenced-by-count":179,"title":["Corneal Allogenic Intrastromal Ring Segments (CAIRS) Combined With Corneal Cross-linking for Keratoconus"],"prefix":"10.3928","volume":"34","author":[{"given":"Soosan","family":"Jacob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaila R.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Ramalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.I.","family":"Saijimol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Michael","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2004.02.050"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.05.016"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.02.012"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0b013e3182774453"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000167883.63266.60"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01605.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20130723-01"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20131112-01"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182031ca0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.08.016"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-12-19"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000126434.95325.24"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(02)01484-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000320585"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181506142"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.05.020"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067210901900222"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100804-03"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.90136"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-017-0105-7"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(98)80284-8"},{"key":"e_1_3_3_23_2","first-page":"496","article-title":"Contact lens-assisted corneal cross-linking","volume":"31","author":"Kumar DA","year":"2015","unstructured":"Kumar DA, Jacob S, Agarwal A. 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