{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:40:28Z","timestamp":1794368428379,"version":"4.9.0"},"reference-count":41,"publisher":"SLACK, Inc.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE:<\/jats:title>\n            <jats:p>To evaluate and compare epithelial remodeling after standard corneal cross-linking (S-CXL) and iontophoresis-assisted CXL (I-CXL) in eyes with keratoconus by anterior segment optical coherence tomography (AS-OCT).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>In this prospective, observational study, AS-OCT and corneal topography were performed before and 1, 3, and 6 months after surgery. Corneal pachymetry was performed and epithelial and stromal thicknesses (central and 16 points on the 6-mm central zone) and the maximum simulated keratometry value (Kmax) were measured.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Two groups of 30 patients (60 eyes total) with progressive keratoconus underwent S-CXL or I-CXL. Before surgery, both groups of patients presented with an irregular epithelial thickness profile. At 6 months postoperatively, localized corneal epithelial thinning was observed in the superior (\n              <jats:italic>P<\/jats:italic>\n              = .026), inferior (\n              <jats:italic>P<\/jats:italic>\n              = .034), inferonasal (\n              <jats:italic>P<\/jats:italic>\n              = .024), and nasal (\n              <jats:italic>P<\/jats:italic>\n              = .035) areas at 3 mm and in the superior (\n              <jats:italic>P<\/jats:italic>\n              = .039), nasal (\n              <jats:italic>P<\/jats:italic>\n              = .043), and inferior (\n              <jats:italic>P<\/jats:italic>\n              = .01) areas at 6 mm in the SCXL group. Localized corneal epithelial thinning was observed at 3 (\n              <jats:italic>P<\/jats:italic>\n              = .04) and 6 (\n              <jats:italic>P<\/jats:italic>\n              = .01) mm in the inferior area in the I-CXL group. No significant stromal changes were observed for either group. Kmax was stable in both groups at 6 months.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Significant epithelial remodeling occurs after S-CXL, resulting in a thinner, more regular thickness profile than after I-CXL. Epithelial thickness profile measurements after I-CXL could be used as an adjunctive follow-up tool for monitoring the efficacy of CXL in progressive keratoconus.<\/jats:p>\n            <jats:p>\n              <jats:bold>\n                [\n                <jats:italic>J Refract Surg.<\/jats:italic>\n                2018;34(8):551\u2013558.]\n              <\/jats:bold>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/1081597x-20180702-01","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T19:38:23Z","timestamp":1533757103000},"page":"551-558","source":"Crossref","is-referenced-by-count":20,"title":["Early Epithelial Remodeling After Standard and Iontophoresis-Assisted Corneal Cross-linking as Evaluated by Spectral-Domain Optical Coherence Tomography"],"prefix":"10.3928","volume":"34","author":[{"given":"Raphael","family":"Atia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Jouve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otman","family":"Sandali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Laroche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Borderie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nacim","family":"Bouheraoua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20090610-06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20130129-08"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182a15cee"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100218-01"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.05.027"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18938"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000350630"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.06.043"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680490513182"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.03.052"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.10.021"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.023"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001102"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.11.036"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02228.x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.03.026"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.10.041"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-017-0657-2"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13032"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.01.040"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001062"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15662"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20140120-08"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100930-01"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S31524"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2006.00459.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.05.036"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20080601-05"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.09.033"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.02.036"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2017.12.021"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000225720.38748.58"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.05.042"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.06.031"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20160531-02"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2011.01.029"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.06.067"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.12.013"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17569"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001383"}],"container-title":["Journal 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