{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:21:56Z","timestamp":1779160916400,"version":"3.51.4"},"reference-count":31,"publisher":"SLACK, Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[2019,3]]},"abstract":"\n PURPOSE:<\/jats:title>\n To test for an association between stiffening following corneal cross-linking (CXL) and demarcation line depth.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n Sixty-six eyes of 66 patients treated with CXL for progressive keratoconus were included. Dynamic corneal response parameters (DCRs) were measured with the Corvis ST (Oculus Optikger\u00e4te GmbH; Wetzlar, Germany) on the day of CXL and after 1 month. Demarcation line was measured 4 weeks after CXL. A multivariate general linear model was used to test for an association between the change in DCRs and the ratio between demarcation line depth and the postoperative pachymetry.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n The authors found no significant associations between the change in inverse concave integrated radius (1\/R) and the demarcation line ratio (\n P<\/jats:italic>\n = .46), age (\n P<\/jats:italic>\n = .33), sex (\n P<\/jats:italic>\n = .11), preoperative maximum keratometry (\n P<\/jats:italic>\n = .10), and laterality (\n P<\/jats:italic>\n = .82). Similarly, there was no significant correlation between the change in 1\/R and the demarcation line ratio (\n R<\/jats:italic>\n 2<\/jats:sup>\n = .002 and\n P<\/jats:italic>\n = .75). However, there was a significant association between the preoperative values of 1\/R and the respective change in 1\/R (\n P<\/jats:italic>\n < .0001). The change in 1\/R was inversely proportional to the patient's preoperative 1\/R; stiffer corneas (lower values of 1\/R) were less affected than less stiff corneas (\n R<\/jats:italic>\n 2<\/jats:sup>\n = .23,\n P<\/jats:italic>\n < .0001).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n CXL is associated with changes in DCRs, suggesting a change in corneal biomechanics following CXL. These changes do not appear to be associated with the demarcation line depth.<\/jats:p>\n \n \n [\n J Refract Surg<\/jats:italic>\n . 2019;35(3):202\u2013206.]\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3928\/1081597x-20190124-01","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T11:39:46Z","timestamp":1552304386000},"page":"202-206","source":"Crossref","is-referenced-by-count":32,"title":["Assessment of the Association Between In Vivo Corneal Biomechanical Changes After Corneal Cross-linking and Depth of Demarcation Line"],"prefix":"10.3928","volume":"35","author":[{"given":"Riccardo","family":"Vinciguerra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argyrios","family":"Tzamalis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esmaeil M.","family":"Arbabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Batterbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen B.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1253"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/11483_5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680490513182"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8059"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.11.036"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.10.021"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.12.039"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.023"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/404587"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S117372"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20160629-02"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20141021-06"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000875"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2015.1077515"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20160524-01"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-016-0035-9"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20161221-03"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20160629-01"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20170213-01"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20180103-01"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20170922-02"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.09.048"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20180104-01"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.06.013"},{"key":"e_1_3_2_27_2","article-title":"New stiffness parameter in air puff induced corneal deformation analysis","volume":"57","author":"Roberts CJ","year":"2016","unstructured":"Roberts CJ, Mahmoud AM, Bons J, et al. 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