{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:22:00Z","timestamp":1782984120604,"version":"3.54.5"},"reference-count":34,"publisher":"SLACK, Inc.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[2019,8]]},"abstract":"\n PURPOSE:<\/jats:title>\n To evaluate the long-term endothelial cell density (ECD) change and its correlation with preoperative anterior chamber depth (ACD) and aqueous depth (AQD) in patients with iris-fixated phakic intraocular lenses (pIOLs).<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n A total of 90 eyes from 57 patients who underwent pIOL implantation were retrospectively enrolled. Correlation between ACD and endothelial cell loss (ECL) was investigated. Optimal cut-off values for ACD and AQD were assessed.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n The average follow-up period was 11.8 \u00b1 2.0 years (range: 9.1 to 17.3 years). Compared to the baseline data, the mean ECD change was \u2212894 \u00b1 732 cells\/mm\n 2<\/jats:sup>\n (range: \u22122,281 to 389 cells\/mm\n 2<\/jats:sup>\n ). The mean ECD change from baseline was \u221253.5% \u00b1 19.1% (range: \u221275.1% to \u22125.2%) in eyes with preoperative ACD of 3.20 mm or greater \u221226.0% \u00b1 26.6% (range: \u221274.1% to 0.9%) in eyes with ACD of 3.21 to 3.49 mm, and \u22125.2 \u00b1 8.7% (range: \u221221.3% to 16.8%) in eyes with ACD of 3.50 mm or greater (\n P<\/jats:italic>\n < .001). No eyes with ACD of 3.50 mm or greater had significant endothelial cell loss (SECL), whereas 84% of the eyes with ACD of 3.20 mm or less experienced SECL (\n P<\/jats:italic>\n < .001). There was a significant negative correlation between ECL and ACD (\n r<\/jats:italic>\n = \u22120.70,\n P<\/jats:italic>\n < .001) and AQD (\n r<\/jats:italic>\n = \u22120.65,\n P<\/jats:italic>\n < .001). Receiver operating characteristic curve analysis revealed that ACD of 3.35 mm provides 84% sensitivity and 88% specificity and AQD of 2.75 mm provides 88% sensitivity and 81% specificity for preventing SECL.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Smaller ACD and AQD are significantly correlated with more ECL. Minimum ACD of 3.35 mm or AQD of 2.75 mm are recommended for better long-term endothelial safety.<\/jats:p>\n \n \n [\n J Refract Surg.<\/jats:italic>\n 2019;35(8):493\u2013500.]\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3928\/1081597x-20190708-01","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T20:25:44Z","timestamp":1565295944000},"page":"493-500","source":"Crossref","is-referenced-by-count":13,"title":["Long-Term Effect of Anterior Chamber Depth on Endothelial Cell Density in Patients With Iris-Fixated Phakic Intraocular Lenses"],"prefix":"10.3928","volume":"35","author":[{"given":"Alaa M.","family":"Eldanasoury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Roozbahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Tolees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Arana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.08.014"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.06.037"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20110203-01"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.05.025"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(00)00545-9"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.6.775"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.08.011"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.05.036"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.08.023"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.01.037"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2016.08.027"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.08.022"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2015.05.030"},{"key":"e_1_3_3_15_2","unstructured":"OPHTEC Refractive Surgery. The IRIS (ARTISAN ARTIFLEX); 2018. https:\/\/www.ophtec.com\/products\/refractive-surgery\/piols\/artisan-myopiamodel-204. Accessed April 18 2019."},{"key":"e_1_3_3_16_2","unstructured":"Artisan\u00ae Phakic IOL Facts You Need to Know About Implantation of the Artisan\u00ae Phakic IOL (\u22125 TO \u221220 D) for the correction of myopia (nearsightedness). Patient information brochure. 2004. https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf3\/P030028d.pdf. 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