{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:38:58Z","timestamp":1786653538012,"version":"build-2736575974"},"reference-count":56,"publisher":"SLACK, Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objective:<\/jats:title>\n                    <jats:p>To measure the concentrations of transforming growth factor-beta1 and beta2 (TGF-beta1 and TGF-beta2) in the aqueous humor of patients with neovascular glaucoma (NVG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>Patients were divided into four groups: NVG secondary to central retinal vein occlusion (group 1), NVG secondary to proliferative diabetic retinopathy (group 2), central retinal vein occlusion without rubeosis (group 3), and senile cataract (group 4). The total TGF-beta1 and TGF-beta2 concentrations in the aqueous humor of the four groups were measured by enzyme linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean concentrations of total TGF-beta1 were 600.7 \u00b1 436.7 \u00b5g\/mL in group 1, 802.0 \u00b1 359.5 \u00b5g\/mL in group 2, and undetectable in groups 3 and group 4 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). The mean concentrations of to tal TGF-beta2 were 6,307.9 \u00b1 2,206.2 \u00b5g\/mL in group 1, 5,908.0 \u00b1 2,033.2 \u00b5g\/mL in group 2, 899.7 \u00b1 425.6 \u00b5g\/mL in group 3, and 385.7 \u00b1 189.9 \u00b5g\/mL in group 4. The total TGF-beta1 and TGF-beta2 concentrations in groups 1 and 2 were significantly higher than those in groups 3 and 4, whereas the total TGF-beta2 concentration in group 3 was significantly higher than that in group 4 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). There was no significant difference in the TGF-beta1 or TGF-beta2 concentrations between groups 1 and 2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The abnormally high concentrations of TGF-beta1 and TGF-beta2 in the aqueous humor of patients with NVG may explain some aspects of the pathogenesis of NVG and the high failure rate of filtering operations in NVG.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>[Ophthalmic Surg Lasers Imaging 2007;38:6\u201314.]<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3928\/15428877-20070101-01","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T14:10:56Z","timestamp":1570111856000},"page":"6-14","source":"Crossref","is-referenced-by-count":39,"title":["Increased Levels of Transforming Growth Factor-Beta1 and -Beta2 in the Aqueous Humor of Patients With Neovascular Glaucoma"],"prefix":"10.3928","volume":"38","author":[{"given":"Xiao-Bo","family":"Yu","sequence":"first","affiliation":[{"name":"The Department of Ophthalmology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Huai","family":"Sun","sequence":"additional","affiliation":[{"name":"The Department of Ophthalmology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Dahan","sequence":"additional","affiliation":[{"name":"Shanghai Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China; the Department of Ophthalmology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yi","family":"Guo","sequence":"additional","affiliation":[{"name":"The Department of Ophthalmology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Hong","family":"Qian","sequence":"additional","affiliation":[{"name":"The Department of Ophthalmology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Rong","family":"Meng","sequence":"additional","affiliation":[{"name":"The Department of Ophthalmology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Lian","family":"Song","sequence":"additional","affiliation":[{"name":"The Department of Ophthalmology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy J.","family":"Ben Simon","sequence":"additional","affiliation":[{"name":"University of the Witwatersrand, Johannesburg, South Africa; and The Royal Victorian Eye &amp; Ear Hospital, East Melbourne, Victoria, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34293-2"},{"key":"e_1_3_1_3_2","first-page":"137","article-title":"The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases","volume":"68","author":"Michaelson IC","year":"1948","unstructured":"Michaelson IC. 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