{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:24:19Z","timestamp":1787030659089,"version":"build-2736575974"},"reference-count":21,"publisher":"SLACK, Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objective:<\/jats:title>\n                    <jats:p>To report on preliminary findings of adjunctive subconjunctival bevacizumab (SCB) injections in patients undergoing Ahmed valve implantation (AVI) (New World Medical, Rancho Cucamonga, CA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>The study was approved by the institution\u2019s ethics committee. Patients were prospectively recruited during a 1-month period and randomized to receive AVI with postoperative SCB (days 1 and 7, n = 7) or AVI without SCB (n = 6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Baseline intraocular pressure (IOP) in the treatment (AVI+SCB) group was 19.4 \u00b1 8.6 mm Hg, whereas baseline IOP in the control (AVI) group was 32.1 \u00b1 17.7 mm Hg (\n                      <jats:italic>P<\/jats:italic>\n                      = .119). Final IOP was 13.8 mm Hg (n = 7) for the treatment group and 12.7 mm Hg for the control group (n = 5,\n                      <jats:italic>P<\/jats:italic>\n                      = .790). One eye in the control group required further glaucoma intervention at day 45 and was considered a failure. The pre-massage postoperative IOP was significantly lower for the treatment group only at day 45 (16.1 vs 26.0 mm Hg,\n                      <jats:italic>P<\/jats:italic>\n                      = .012). Mean post-massage IOP was significantly lower in the treatment group at day 15 (11.28 vs 17.16 mm Hg,\n                      <jats:italic>P<\/jats:italic>\n                      = .004), day 30 (11.28 vs 20.83 mm Hg,\n                      <jats:italic>P<\/jats:italic>\n                      = .015), and day 45 (12.16 vs 21.33 mm Hg,\n                      <jats:italic>P<\/jats:italic>\n                      = .001), and similar at month 3. Mean change in bleb area was 11.4 mm\n                      <jats:sup>2<\/jats:sup>\n                      in the treatment group and \u22120.4 mm\n                      <jats:sup>2<\/jats:sup>\n                      in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      = .036 and\n                      <jats:italic>P<\/jats:italic>\n                      = .361, respectively, Student\u2019s paired samples\n                      <jats:italic>t<\/jats:italic>\n                      test).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Bevacizumab was associated with a less aggressive hypertensive period as measured by post-massage IOP measurements, postoperative glaucoma medications, and cross-sectional bleb area by ultrasound. Further prospective studies are needed to better understand the utility of SCB at the time of AVI surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3928\/15428877-20110316-02","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T06:42:30Z","timestamp":1618987350000},"page":"132-137","source":"Crossref","is-referenced-by-count":16,"title":["Adjunctive Bevacizumab in Patients Undergoing Ahmed Valve Implantation: A Pilot Study"],"prefix":"10.3928","volume":"42","author":[{"given":"Mar\u00eda","family":"Rojo-Arnao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar D.","family":"Albis-Donado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Lliteras-Cardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik Y.","family":"Kahook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Gil-Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.07.011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00394-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/10065_6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3129\/I07-188"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31819c485b"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3180640f58"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.056143"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.8.994"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3928\/1542-8877-20060301-12"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.03.058"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.02.045"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.095190"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1076\/ocii.6.1.27.8078"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.67039"},{"key":"e_1_3_2_16_2","first-page":"213","volume-title":"Documenta Ophthalmologica Proceedings Series 61, Ultrasonography in Ophthalmology 15, Proceedings of the 15th SIDUO Congress","author":"Moragrega E","year":"1994","unstructured":"Moragrega E, Velasco-Barona C, Sanchez V, Gil F. Echographic evaluation of the Ahmed valves. In: , Gennamo G, Rosa N, eds. Documenta Ophthalmologica Proceedings Series 61, Ultrasonography in Ophthalmology 15, Proceedings of the 15th SIDUO Congress. Cortina, Italy: Kluwer Academic Publishers; 1994:213\u2013218."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1994.1037"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"Li Z Van Bergen T Van de Veire S et al. Inhibition of vascular endothelial growth factor reduces scar formation after glaucoma filtration surgery. 2009; 50 :5217\u20135225.","DOI":"10.1167\/iovs.08-2662"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e3283360aad"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.03.030"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181efbec0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3949"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T22:59:55Z","timestamp":1683068395000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/15428877-20110316-02"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.3928\/15428877-20110316-02"],"URL":"https:\/\/doi.org\/10.3928\/15428877-20110316-02","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}