{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T10:13:01Z","timestamp":1715940781900},"reference-count":11,"publisher":"SLACK, Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n            <jats:p>To evaluate a minimally invasive injector for intravitreal and subconjunctival administration of medications.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS:<\/jats:title>\n            <jats:p>The device has a microneedle that communicates with an internal formulation chamber. A piercing depth-limiting flange restricts microneedle penetration to a depth of less than 1 mm and defines the location of the pars plana from the limbus. The jet injector creates a force of up to 1,000 psi, forcing the medication through the remaining sclera\/choroid thickness. The device was tested in 28 enucleated rabbit eyes and 9 experimental and 4 control rabbit eyes to define jet pressure for subconjunctival and intravitreal injection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Injection pressures of 76 to 156 psi were needed for subconjunctival injection and 974 psi for intravitreal injection. Clinical and histologic examinations did not reveal damage to intraocular structures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>The semi-automated jet injector facilitated intravitreal\/subconjunctival injection. The microneedle-assisted jet injector minimized the risk of wet injection by anchoring the microneedle in the sclera.<\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/15428877-20111129-05","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T14:57:50Z","timestamp":1326812270000},"page":"57-62","source":"Crossref","is-referenced-by-count":3,"title":["A Minimally Invasive Jet Injector for Intravitreal and Subconjunctival Injection"],"prefix":"10.3928","volume":"43","author":[{"given":"Gholam A.","family":"Peyman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Cormier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181a94f01"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.31.9.517"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30297-8"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2009.0027"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1974.01010010155016"},{"key":"e_1_3_1_7_2","first-page":"666","article-title":"Toxicity of intravitreal antiviral drugs","volume":"15","author":"Pulido JS","year":"1984","unstructured":"Pulido JS, Palacio M, Peyman GA, Fiscella R, Greenberg D, Stelmack T. Toxicity of intravitreal antiviral drugs. Ophthalmic Surg. 1984;15:666\u2013669.","journal-title":"Ophthalmic Surg"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.3928\/1542-8877-20050701-14"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200603000-00001"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.4.460"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.099598"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.01067.x"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.slackinc.com\/doi\/resolver.asp?doi=10.3928\/15428877-20111129-05","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T06:40:16Z","timestamp":1683096016000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/15428877-20111129-05"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.3928\/15428877-20111129-05"],"URL":"https:\/\/doi.org\/10.3928\/15428877-20111129-05","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}