{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:53:16Z","timestamp":1788274396131,"version":"build-2803163510"},"reference-count":20,"publisher":"SLACK, Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n            <jats:p>To document cases of sustained elevation of intraocular pressure (IOP) while receiving intravitreal anti-vascular endothelial growth factor (VEGF) agents and subsequent management.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS:<\/jats:title>\n            <jats:p>A retrospective series of all cases managed by the authors and colleagues was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Six patients developed sustained elevated IOP; five received ranibizumab and one bevacizumab. Four received unilateral and two received bilateral injections. Two had preexisting primary open-angle glaucoma and one had pseudoexfoliative glaucoma, all with stable IOP prior to anti-VEGF treatment. Angles were open in all cases. Peak IOP averaged 43 mm Hg (range: 34 to 60 mm Hg). The mean number of injections preceding the IOP increase was 10 (range: 1 to 20). Four patients required trabeculectomy, one selective laser trabeculoplasty, and one multiple topical medications.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>A sustained increase in IOP requiring glaucoma filtering surgery is a rare but important treatment complication for patients receiving intravitreal anti-VEGF therapy, especially those with preexisting glaucoma or glaucoma risk factors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/15428877-20120618-01","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T07:26:29Z","timestamp":1342164389000},"page":"328-334","source":"Crossref","is-referenced-by-count":24,"title":["Glaucoma Filtration Surgery Following Sustained Elevation of Intraocular Pressure Secondary to Intravitreal Anti-VEGF Injections"],"prefix":"10.3928","volume":"43","author":[{"given":"Simon E.","family":"Skalicky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Agar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Bank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054481"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062655"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.02.031"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.02.021"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740330903418422"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.07.007"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6703018"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20090430-12"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0819-2"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.180729"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2009.0076"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067211002000124"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31819c4893"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.09.012"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.05.036"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3180de1d0a"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.06.002"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181ca74de"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31816c6868"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6431"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/15428877-20120618-01","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T06:28:45Z","timestamp":1683095325000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/15428877-20120618-01"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.3928\/15428877-20120618-01"],"URL":"https:\/\/doi.org\/10.3928\/15428877-20120618-01","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}