{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:42:21Z","timestamp":1775576541853,"version":"3.50.1"},"reference-count":18,"publisher":"SLACK, Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p>Retinal astrocytic hamartoma or retinal astrocytoma is the best-known ocular manifestation of tuberous sclerosis complex, a neurocutaneous syndrome characterized by the development of multiple disseminated hamartomas. It can have several clinical presentations, ranging from unilateral transparent, noncalcified lesions to bilateral multinodular, mulberrylike calcified tumors. Symptoms appear if the tumor involves the macula and can cause visual loss on the basis of progressive retinal degeneration. The authors report a case of a patient with tuberous sclerosis, bilateral astrocytic hamartomas, and macular edema with intraretinal hemorrhage in the left eye that has responded well to treatment with bevacizumab and intravitreal triamcinolone acetonide.<\/jats:p>","DOI":"10.3928\/23258160-20121221-19","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T20:26:51Z","timestamp":1357676811000},"page":"85-90","source":"Crossref","is-referenced-by-count":23,"title":["Combined Bevacizumab and Triamcinolone Acetonide Injections for Macular Edema in a Patient with Astrocytic Hamartomas and Tuberous Sclerosis"],"prefix":"10.3928","volume":"44","author":[{"given":"Marcela","family":"Lonngi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron S.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy G.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.05.004"},{"key":"e_1_3_1_3_2","first-page":"139","article-title":"Aggressive retinal astrocytomas in four patients with tuberous sclerosis complex","volume":"102","author":"Shields JA","year":"2004","unstructured":"Shields JA, Eagle RC, Shields CL, Marr BP. Aggressive retinal astrocytomas in four patients with tuberous sclerosis complex. Trans Am Ophthalmol Soc. 2004;102:139\u2013148.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.optm.2009.12.009"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2007.00213.x"},{"key":"e_1_3_1_6_2","first-page":"1087","volume-title":"Ophthalmology","author":"Augsburger JJ","year":"2008","unstructured":"Augsburger JJ, Cruess AF. Astrocytoma of retina. In: , Yanoff M, Duker JS, eds. Ophthalmology. 3rd ed. St. Louis, MO: Mosby; 2008:1087\u20131092.","edition":"3"},{"key":"e_1_3_1_7_2","volume-title":"Retina","author":"Cruess AF","year":"2006","unstructured":"Cruess AF, Sharma S. Tumors of the retina. In: , Ryan SJ, ed. Retina. 4th ed. Philadelphia, PA: Elsevier; 2006.","edition":"4"},{"key":"e_1_3_1_8_2","volume-title":"Ophthalmology","author":"Augsburger JJ","year":"2008","unstructured":"Augsburger JJ, Bolling JP. Phakomatoses. In: , Yanoff M, Duker JS, eds. Ophthalmology. 3rd ed. St. Louis, MO: Mosby; 2008.","edition":"3"},{"key":"e_1_3_1_9_2","volume-title":"Nelson Textbook of Pediatrics","author":"Sahin M","year":"2011","unstructured":"Sahin M. Neurocutaneous syndromes. In: , Kliegman RM, ed. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, PA: Saunders; 2011: chap 589.","edition":"19"},{"key":"e_1_3_1_10_2","volume-title":"Goldman\u2019s Cecil Medicine","author":"Mink JW","year":"2011","unstructured":"Mink JW. Congenital, developmental, and neurocutaneous disorders. In: , Goldman L, Schafer AI, eds. Goldman\u2019s Cecil Medicine. 24th ed. Philadelphia, PA: Saunders; 2011: chap 426.","edition":"24"},{"key":"e_1_3_1_11_2","first-page":"337","article-title":"Advanced retinoblastoma treatment: targeting hypoxia by inhibition of the mammalian target of rapamycin (mTOR) in LHBETA TAG retinal tumors","volume":"5","author":"Pi\u00f1a Y","year":"2011","unstructured":"Pi\u00f1a Y, Decatur C, Murray TG, et al. Advanced retinoblastoma treatment: targeting hypoxia by inhibition of the mammalian target of rapamycin (mTOR) in LHBETA TAG retinal tumors. Clin Ophthalmol. 2011;5:337\u2013343.","journal-title":"Clin Ophthalmol"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088377"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.03.032"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.03.032"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.4.597"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067211002000424"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01331.x"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-010-0863-4"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235724"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/23258160-20121221-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T23:37:00Z","timestamp":1683070620000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/23258160-20121221-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.3928\/23258160-20121221-19"],"URL":"https:\/\/doi.org\/10.3928\/23258160-20121221-19","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}