{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:06:49Z","timestamp":1762866409213},"reference-count":22,"publisher":"SLACK, Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n BACKGROUND AND OBJECTIVE:<\/jats:title>\n To determine the effectiveness and direct medical costs of treat-and-extend (TAE) intravitreal bevacizumab (IVB) for the treatment of branch retinal vein occlusion (BRVO)\u2013associated macular edema (ME).<\/jats:p>\n <\/jats:sec>\n \n PATIENTS AND METHODS:<\/jats:title>\n Retrospective chart review of 52 consecutive patients diagnosed with BRVO-associated ME treated with IVB using a TAE protocol.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Mean change in logMAR vision was \u22120.30 (\n P<\/jats:italic>\n < .001), and mean change in central macular thickness was \u2212244.0 \u03bcm (\n P<\/jats:italic>\n < .001). The mean number of injections was 8.2 (95% CI; 7.8 to 8.6). The yearly average direct cost of the TAE regimen was calculated to be $2,580.26 per patient.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n Treatment of BRVO-associated ME with IVB using a TAE regimen resulted in similar visual outcomes and number of intravitreal injections as did as-needed treatment with 0.5 mg ranibizumab conducted in phase 3 trials but with fewer visits and lower annual medical costs.<\/jats:p>\n \n \n [\n Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n . 2014;45:212\u2013216.]\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3928\/23258160-20140404-01","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T16:56:45Z","timestamp":1400518605000},"page":"212-216","source":"Crossref","is-referenced-by-count":23,"title":["Treat-and-Extend Intravitreal Bevacizumab for Branch Retinal Vein Occlusion"],"prefix":"10.3928","volume":"45","author":[{"given":"Ryan B.","family":"Rush","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Simunovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Antonio V.","family":"Aragon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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