{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:58:04Z","timestamp":1790427484355,"version":"4.1.0"},"reference-count":11,"publisher":"SLACK, Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Retinal toxicity from hydroxychloroquine (HCQ) can be detected most readily on fundus autofluorescence, spectral-domain optical coherence tomography, and multifocal electroretinogram. The authors describe a case of a 60-year-old woman with a history of systemic lupus erythematosus undergoing HCQ treatment for 30 years who presented with visual loss over several years. Examination and multimodal imaging showed bilateral retinal pigment epithelium (RPE) changes in a bull\u2019s-eye distribution associated with cystoid macular edema. A novel imaging modality, multi-spectral imaging, appeared sensitive in detecting a bull\u2019s-eye pattern of RPE disturbance involving the entire macular region of both eyes. Cessation of drug was advised with close follow-up.<\/jats:p>\n          <jats:p>\n            <jats:bold>\n              [\n              <jats:italic>Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n              . 2015;46:377\u2013379.]\n            <\/jats:bold>\n          <\/jats:p>","DOI":"10.3928\/23258160-20150323-14","type":"journal-article","created":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T14:31:15Z","timestamp":1428071475000},"page":"377-379","source":"Crossref","is-referenced-by-count":22,"title":["Multimodal Imaging in a Severe Case of Hydroxychloroquine Toxicity"],"prefix":"10.3928","volume":"46","author":[{"given":"Kavita V.","family":"Bhavsar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekha K.","family":"Mukkamala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Bailey","family":"Freund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00409-3"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.144402"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.11.017"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2226-2"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303897"},{"issue":"9","key":"e_1_3_1_7_2","first-page":"1187","article-title":"Progression of hydroxychloroquine toxic effects after drug therapy cessation: new evidence from multimodal imaging","volume":"131","author":"Mititelu M","year":"2013","unstructured":"Mititelu M, Wong BJ, Brenner M, et al. Progression of hydroxychloroquine toxic effects after drug therapy cessation: new evidence from multimodal imaging. AMA Ophthalmol. 2013;131(9):1187\u20131197.","journal-title":"AMA Ophthalmol"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.04.012"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01168-5"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2014.28.1.100"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.12.002"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.1099"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/23258160-20150323-14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T23:45:35Z","timestamp":1683071135000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/23258160-20150323-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.3928\/23258160-20150323-14"],"URL":"https:\/\/doi.org\/10.3928\/23258160-20150323-14","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}