{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:08:31Z","timestamp":1791875311052,"version":"4.3.4"},"reference-count":31,"publisher":"SLACK, Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n            <jats:p>To evaluate the effect of oral eplerenone on subretinal fluid, visual acuity, and choroidal thickness in patients with chronic central serous chorioretinopathy (CSCR).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS:<\/jats:title>\n            <jats:p>\n              Retrospective review of all patients (14 eyes of 14 patients) monitored for a minimum of 3 months with chronic CSCR who were treated with oral eplerenone in a single multi-physician retina practice. Visual acuity, dilated funduscopic examination, and spectral-domain ocular coherence tomography (OCT) with enhanced depth imaging (EDI) were obtained at each visit. Measurement of subfoveal fluid (SFF) height and choroidal thickness were performed. Two-tailed paired\n              <jats:italic>t<\/jats:italic>\n              test was used to calculate statistical significance of pre- and post-treatment variables.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              At 1 month, 10 of 14 eyes had decreased SFF height on OCT and two eyes had complete resolution of SFF. Mean SFF height decreased from 13 0\u00b5m to 62 \u00b5m (\n              <jats:italic>P<\/jats:italic>\n              = .05). Mean choroidal thickness decreased from 315 \u00b5m to 282 \u00b5m (\n              <jats:italic>P<\/jats:italic>\n              = .07). Mean visual acuity improved from logMAR 0.41 to 0.40. At 3 months, 13 of 14 (93%) had decreased SFF on OCT, and nine eyes (64%) had complete resolution of SFF. Mean SFF height decreased to 21 \u00b5m (\n              <jats:italic>P<\/jats:italic>\n              = .004). Mean choroidal thickness decreased to 253 \u00b5m (\n              <jats:italic>P<\/jats:italic>\n              = .10). Mean visual acuity improved to logMAR 0.28 (\n              <jats:italic>P<\/jats:italic>\n              = .02).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>Oral eplerenone may be effective in treating patients with chronic CSCR.<\/jats:p>\n            <jats:p>\n              <jats:bold>\n                [\n                <jats:italic>Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n                . 2015;46:439\u2013444.]\n              <\/jats:bold>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/23258160-20150422-06","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T18:53:10Z","timestamp":1449773590000},"page":"439-444","source":"Crossref","is-referenced-by-count":43,"title":["Oral Eplerenone for Treatment of Chronic Central Serous Chorioretinopathy: A Case Series"],"prefix":"10.3928","volume":"46","author":[{"given":"David A.","family":"Salz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"John D.","family":"Pitcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl D.","family":"Regillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S.","family":"Fineman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin S.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Vander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J.","family":"Spirn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2010.130"},{"key":"e_1_3_1_3_2","first-page":"52","volume-title":"Stereoscopic Atlas of Macular Diseases: Diagnosis and Treatment, Vol. 1","author":"Gass JD","year":"1997","unstructured":"Gass JD. Stereoscopic Atlas of Macular Diseases: Diagnosis and Treatment, Vol. 1, 4th edition. St Louis, MO: Mosby; 1997:52\u201370.","edition":"4"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(02)00338-7"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00075-6"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-198700720-00009"},{"issue":"3","key":"e_1_3_1_7_2","first-page":"131","article-title":"Idiopathic Central Serous Chorioretinopathy","volume":"46","author":"Hussain D","year":"1998","unstructured":"Hussain D, Gass JD. Idiopathic Central Serous Chorioretinopathy. 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