{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:34:03Z","timestamp":1771666443631,"version":"3.50.1"},"reference-count":15,"publisher":"SLACK, Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n            <jats:p>To quantitatively evaluate the change in pigment epithelial detachment (PED) morphology on spectral-domain optical coherence tomography (SD-OCT) 18 months after the transition to intravitreal aflibercept in patients with neovascular age-related macular degeneration (AMD) with PED recalcitrant to monthly intravitreal bevacizumab or ranibizumab.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS:<\/jats:title>\n            <jats:p>Retrospective case series examining patients with neovascular AMD who had a persistent fibrovascular or serous PED on SD-OCT. PED volume was calculated by manually outlining the PED on individual OCT slices of the raster scan and multiplying by the pixel dimensions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Eleven eyes of 10 patients who had received an average of 25.7 \u00b1 20.1 (range: 6 to 70) prior bevacizumab or ranibizumab injections over a period of 26.6 \u00b1 19.8 months (range: 4 to 63) were included. PED volume decreased with aflibercept from 0.687 \u00b1 0.837 mm\n              <jats:sup>3<\/jats:sup>\n              to 0.562 \u00b1 0.705 mm\n              <jats:sup>3<\/jats:sup>\n              (\n              <jats:italic>P<\/jats:italic>\n              = .02), a decrease of 19% \u00b1 12.27%.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>After 18 months of aflibercept, recalcitrant PED volumes were reduced by 19% while preserving visual acuity in eyes with neovascular AMD.<\/jats:p>\n            <jats:p>\n              <jats:bold>\n                [\n                <jats:italic>Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n                . 2015;46:638\u2013641.]\n              <\/jats:bold>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/23258160-20150610-07","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T15:51:45Z","timestamp":1435333905000},"page":"638-641","source":"Crossref","is-referenced-by-count":25,"title":["Quantification of Change in Pigment Epithelial Detachment Volume and Morphology After Transition to Intravitreal Aflibercept in Eyes With Recalcitrant Neovascular AMD: 18-Month Results"],"prefix":"10.3928","volume":"46","author":[{"given":"Aditya","family":"Kanesa-Thasan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilraj S.","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjot K.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice T.","family":"Lyon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rukhsana G.","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.02.017"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303344"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31828e8551"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.101"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.02.009"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.035"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2007.02.008"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31827d2657"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_3_1_11_2","first-page":"119","article-title":"Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization","volume":"8","author":"Grossniklaus HE","year":"2002","unstructured":"Grossniklaus HE, Ling JX, Wallace TM, et al. Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol Vis. 2002;8: 119\u2013126.","journal-title":"Mol Vis"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-003-0828-0"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304474"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.31"},{"key":"e_1_3_1_15_2","first-page":"343","article-title":"Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab","volume":"8","author":"Yamashita M","year":"2014","unstructured":"Yamashita M, Nishi T, Hasegawa T, Ogata N. Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab. Clin Ophthalmol. 2014;8:343\u2013346.","journal-title":"Clin Ophthalmol"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000130"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.healio.com\/doiresolver?doi=10.3928\/23258160-20150610-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T23:19:51Z","timestamp":1683069591000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/23258160-20150610-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.3928\/23258160-20150610-07"],"URL":"https:\/\/doi.org\/10.3928\/23258160-20150610-07","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}