{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:52:41Z","timestamp":1758631961835},"reference-count":29,"publisher":"SLACK, Inc.","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2016,12]]},"abstract":"\n BACKGROUND AND OBJECTIVE:<\/jats:title>\n To characterize the in vivo microstructural features of patients with history of retinopathy of prematurity (ROP).<\/jats:p>\n <\/jats:sec>\n \n PATIENTS AND METHODS:<\/jats:title>\n A single-center, retrospective imaging case series during which a chart review was performed of consecutive patients with history of ROP who underwent spectral-domain optical coherence tomography (SD-OCT) with or without enhanced depth imaging. Eyes with time-domain OCT, no light perception, or uninterpretable SD-OCT images were excluded. Main outcome measures included best-corrected visual acuity (BCVA) and exploratory SD-OCT findings.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n A total of 186 eyes of 112 patients (mean age: 31.5 years; range: 8 years to 70 years) were imaged. Mean visual acuity was 20\/150 (range: 20\/20 to light perception). Mean foveal thickness (MFT) and subfoveal choroidal thickness (SCT) measured 270.93 \u00b5m \u00b1 56.40 \u00b5m and 239.87 \u00b5m \u00b1 73.00 \u00b5m, respectively. There was a negative correlation between ROP stage and MFT (Rho = \u22120.19;\n P<\/jats:italic>\n = .027), but not with SCT (Rho = \u22120.03;\n P<\/jats:italic>\n = .748). There were negative correlations between BCVA and MFT (Rho = \u22120.23;\n P<\/jats:italic>\n < .01) and SCT (Rho = \u22120.19;\n P<\/jats:italic>\n = .04). Ellipsoid zone (EZ) abnormalities, inner retinal layer thickening, and presence of chorioretinal atrophy were associated with higher ROP stage (\n P<\/jats:italic>\n < .001) and poorer visual acuity (Rho = 0.59;\n P<\/jats:italic>\n < .001). The presence of retinoschisis (n = 36\/186; 19%) was associated with poorer visual acuity (\n P<\/jats:italic>\n < .001), but did not correlate with higher ROP stage (\n P<\/jats:italic>\n = .17). Epiretinal membrane-like dense hyaloidal organization and vitreoretinal interface abnormalities were seen in 69% (130\/186) and 33% (63\/186) of eyes, respectively, but were not associated with ROP stage (\n P<\/jats:italic>\n = .87) or visual acuity (\n P<\/jats:italic>\n = .54). After controlling for EZ abnormalities, foveal hypoplasia, macular schisis, inner retinal thickening, chorioretinal atrophy, and ROP stage, the independent risk factors for poorer visual acuity were EZ abnormalities (Beta = 0.38;\n P<\/jats:italic>\n < .001), chorioretinal atrophy (Beta = 0.18;\n P<\/jats:italic>\n = .03), and ROP stage (Beta = 0.22;\n P<\/jats:italic>\n < .01).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n SD-OCT imaging identified a variety of microstructural abnormalities present in patients with history of ROP.<\/jats:p>\n \n \n [\n Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n . 2016;47:1086\u20131094.]\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3928\/23258160-20161130-02","type":"journal-article","created":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T03:12:49Z","timestamp":1481857969000},"page":"1086-1094","source":"Crossref","is-referenced-by-count":8,"title":["Spectral-Domain Optical Coherence Tomography in Older Patients With History of Retinopathy of Prematurity"],"prefix":"10.3928","volume":"47","author":[{"given":"Aristomenis","family":"Thanos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Yonekawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bozho","family":"Todorich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly A.","family":"Drenser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Trese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Antonio","family":"Capone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(42)92088-9"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.192"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.05.017"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1982.01030030258004"},{"key":"e_1_3_1_6_2","first-page":"225","article-title":"Retinopathy of prematurity: late complications in the baby boomer generation (1946\u20131964)","volume":"103","author":"Smith BT","year":"2005","unstructured":"Smith BT, Tasman WS. Retinopathy of prematurity: late complications in the baby boomer generation (1946\u20131964). 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Surgical management of tractional retinoschisis associated with vitreous hemorrhage in retinopathy of prematurity. Retin Cases Brief Rep. In press.","journal-title":"Retin Cases Brief Rep"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080170115037"},{"key":"e_1_3_1_29_2","first-page":"1886","article-title":"M\u00fcller cell activation, proliferation and migration following laser injury","volume":"15","author":"Tackenberg M","year":"2009","unstructured":"Tackenberg M. M\u00fcller cell activation, proliferation and migration following laser injury. Mol Vis. 2009;15:1886\u20131896.","journal-title":"Mol Vis"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.05.017"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/ophthalmology\/journals\/osli\/2016-12-47-12\/%7B3c675a3d-2196-4468-a6ff-a899f791f0a0%7D\/spectral-domain-optical-coherence-tomography-in-older-patients-with-history-of-retinopathy-of-prematurity","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T12:08:04Z","timestamp":1683115684000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/23258160-20161130-02"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.3928\/23258160-20161130-02"],"URL":"https:\/\/doi.org\/10.3928\/23258160-20161130-02","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}