{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:22:18Z","timestamp":1774617738703,"version":"3.50.1"},"reference-count":21,"publisher":"SLACK, Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n            In a prospective case series of patients with Blau-Jabs syndrome (BJS) conducted in the Ophthalmology Department\/Federal University of Sao Paulo, seven patients with clinical and ophthalmologic manifestations of the disease and a positive genetic test result for the presence of a mutation in the\n            <jats:italic>CARD15\/NOD2<\/jats:italic>\n            gene were followed for a minimal period of 1 year. All patients had uveitis, five had nummular corneal subepithelial opacities, and four had multifocal choroiditis. Oral prednisolone was administered to all patients; inflammation was controlled in six patients with at least one immunosuppressive drug. Infliximab (Remicade; Janssen Pharmaceuticals, Beerse, Belgium) and etanercept (Enbrel; Amgen, Thousand Oaks, CA) were used to treat two cases refractory to the anti-inflammatory drugs. A subconjunctival dexamethasone implant (Ozurdex; Allergan, Irvine, CA) and a periocular injection of triamcinolone were used in one case to achieve inflammation control. Six patients achieved a visual acuity of 20\/25 or better. The authors conclude that periocular treatment with steroid injections might be effective adjuvant therapy to control ocular inflammation.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              [\n              <jats:italic>Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n              . 2018;49:70\u201375.]\n            <\/jats:bold>\n          <\/jats:p>","DOI":"10.3928\/23258160-20171215-12","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T17:27:53Z","timestamp":1515173273000},"page":"70-75","source":"Crossref","is-referenced-by-count":8,"title":["Blau-Jabs Syndrome in a Tertiary Ophthalmologic Center"],"prefix":"10.3928","volume":"49","author":[{"given":"Heloisa","family":"Nascimento","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M.","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9lia Gonz\u00e1lez","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo H.A.","family":"Salom\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elcio. 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