{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:21:30Z","timestamp":1761844890571},"reference-count":33,"publisher":"SLACK, Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n            <jats:p>Stereotactic radiotherapy (SRT) is a new adjuvant treatment modality that has been shown to reduce the need for repetitive intravitreal injections (IVIs) in patients with neovascular age-related macular degeneration (nAMD). The authors aimed to determine baseline predictors of clinical response to SRT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS:<\/jats:title>\n            <jats:p>This was a retrospective, observational case series of patients with nAMD who underwent SRT and subsequently had at least 12 months of complete follow-up. After SRT and one mandatory IVI, patients were examined every 4 weeks and received further treatment on a pro re nata basis. Examination included enhanced depth imaging spectral-domain optical coherence tomography (SD-OCT) to measure subfoveal choroidal thickness (SFCT) and central macular thickness (CMT). Patients' data were retrieved from medical records and included demographics, disease duration, lesion size, best-corrected visual acuity (BCVA), previous number of IVIs, and type of drug applied.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              A total of 35 eyes of 35 patients (76.23 years \u00b1 7.05 years) were included, and 21 eyes (60%) responded well to SRT. The annual injection rate decreased from 6.86 before SRT to 3.46 afterward, whereas BCVA improved from 0.49 logMAR at baseline to 0.37 logMAR at final follow-up. From a morphologic point of view, CMT and SFCT decreased by 71 \u03bcm and 37 \u03bcm, respectively, at 12-month follow-up compared to baseline. Of all investigated parameters, only SFCT proved to be significant, as a higher baseline SFCT was found to be a strong negative predictor for the number of IVIs needed after SRT (regression coefficient: \u22120.678;\n              <jats:italic>P<\/jats:italic>\n              &lt; .001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Baseline SFCT may help predict which patients with nAMD will respond more favorably to SRT. The authors found eyes with a thicker baseline SFCT needed fewer IVIs after SRT.<\/jats:p>\n            <jats:p>\n              <jats:bold>\n                [\n                <jats:italic>Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n                . 2018;49:320\u2013328.]\n              <\/jats:bold>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/23258160-20180501-05","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T17:40:36Z","timestamp":1526578836000},"page":"320-328","source":"Crossref","is-referenced-by-count":6,"title":["Subfoveal Choroidal Thickness as a Potential Predictor of Clinical Response to Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration"],"prefix":"10.3928","volume":"49","author":[{"given":"Mahdy","family":"Ranjbar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annekatrin","family":"Holzhey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Rades","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Grisanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.15.1900"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(03)00030-4"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305327"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.4.3.6"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.163907"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000425709"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.02.016"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000283"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005729"},{"issue":"0","key":"e_1_3_1_11_2","first-page":"1","article-title":"Changes in peripapillary nerve fiber layer thickness after adjuvant stereotactic radiotherapy in patients with neovascular age-related macular degeneration","volume":"0","author":"Ranjbar M","year":"2017","unstructured":"Ranjbar M, Kurz M, Holzhey A, Rades D, Grisanti S. Changes in peripapillary nerve fiber layer thickness after adjuvant stereotactic radiotherapy in patients with neovascular age-related macular degeneration. Current Eye Research. 2017;0(0):1\u20139.","journal-title":"Current Eye Research"},{"issue":"2","key":"e_1_3_1_12_2","first-page":"202","article-title":"[Statement of the German Ophthalmological Society, the German Retina Society and the Professional Association of German Ophthalmologists: The anti-VEGF therapy in neovascular age-related macular degeneration: Therapeutic Strategies (November 2014)]","volume":"232","author":"German Ophthalmological Society, the German Retina Society and the Professional Association of German Ophthalmologists","year":"2015","unstructured":"German Ophthalmological Society, the German Retina Society and the Professional Association of German Ophthalmologists. [Statement of the German Ophthalmological Society, the German Retina Society and the Professional Association of German Ophthalmologists: The anti-VEGF therapy in neovascular age-related macular degeneration: Therapeutic Strategies (November 2014)]. Klin Monbl Augenheilkd. 2015;232(2):202\u2013210.","journal-title":"Klin Monbl Augenheilkd"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.01.019"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.09.033"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.08.026"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-3221-x"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.10.1353"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16000"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.08.009"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9619"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14646"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19772"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318195cb15"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.135640"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01412.x"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.04.014"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443030"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.3109\/02713688908996381"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1676-7"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/55\/23\/S06"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133968"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.06.021"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8782"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7364"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/23258160-20180501-05","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T19:31:28Z","timestamp":1683055888000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/23258160-20180501-05"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.3928\/23258160-20180501-05"],"URL":"https:\/\/doi.org\/10.3928\/23258160-20180501-05","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}