{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T21:24:35Z","timestamp":1750713875414},"reference-count":11,"publisher":"SLACK, Inc.","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n            A 12-year-old male presented for evaluation of asymptomatic bilateral retinal tumors. Both eyes contained whitish-gray retinal tumors with intralesional calcifications. Enhanced depth optical coherence tomography and high-resolution (20 MHz) ultrasonography narrowed the differentiation diagnosis to astrocytic hamartoma versus retinocytoma. Genetic testing of a saliva sample was negative for tuberous sclerosis complex but positive for a novel mutation in the retinoblastoma gene (\n            <jats:italic>RB1<\/jats:italic>\n            ). Taken together, these findings were consistent with a diagnosis of bilateral retinocytoma in a patient with germline\n            <jats:italic>RB1<\/jats:italic>\n            mutation. This case demonstrates the importance of combining clinical imaging and genetic testing in the evaluation of bilateral intraocular tumors.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              [\n              <jats:italic>Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n              . 2018;49:812\u2013814.]\n            <\/jats:bold>\n          <\/jats:p>","DOI":"10.3928\/23258160-20181002-11","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T20:18:10Z","timestamp":1541449090000},"page":"812-814","source":"Crossref","is-referenced-by-count":2,"title":["Diagnosis of Bilateral Retinocytoma in an Adolescent Patient Using Multimodal Imaging and Genetic Testing"],"prefix":"10.3928","volume":"49","author":[{"given":"Manuel","family":"Paez-Escamilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamalesh J.","family":"Ramaiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. William","family":"Harbour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/13816819109029394"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1982.87"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.5858\/133.8.1203"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2011-300896"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1976.03910040149003"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000634"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20150521-13"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000374"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.126"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1998)12:6<434::AID-HUMU16>3.0.CO;2-7"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.11.1699"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/23258160-20181002-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T03:32:22Z","timestamp":1683084742000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/23258160-20181002-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.3928\/23258160-20181002-11"],"URL":"https:\/\/doi.org\/10.3928\/23258160-20181002-11","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]}}}