{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T23:05:43Z","timestamp":1745276743441},"reference-count":24,"publisher":"SLACK, Inc.","issue":"S1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n            <jats:p>\n              To investigate in vitro microbiological susceptibilities of\n              <jats:italic>Candida<\/jats:italic>\n              vitreous endophthalmitis isolates using traditional and newer antifungal agents.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS:<\/jats:title>\n            <jats:p>\n              The current study is a retrospective, consecutive case series of 17 vitreous culture-proven\n              <jats:italic>Candida<\/jats:italic>\n              endophthalmitis isolates from 2011 to 2017 from Bascom Palmer Eye Institute. Susceptibilities to echinocandins, triazoles, polyenes, and nucleoside analogs were obtained.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              The study isolates consisted of 59% C.\n              <jats:italic>albicans<\/jats:italic>\n              , 17%\n              <jats:italic>C. glabrata<\/jats:italic>\n              , 12%\n              <jats:italic>C. tropicalis,<\/jats:italic>\n              and 12%\n              <jats:italic>C. parapsilosis<\/jats:italic>\n              . Isolates demonstrated 100% sensitivity to all antifungals tested except anidulafungin (85% sensitive) and fluconazole (88.2% sensitive). Comparing in-class agents, minimum inhibitory concentration (MIC) values for voriconazole were lower than other triazoles, whereas micafungin had lower MIC values compared with other echinocandins.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>\n              Both traditional and newer antifungals included agents that were highly efficacious against in vitro\n              <jats:italic>Candida<\/jats:italic>\n              species. Although the authors' study data suggest that older, established antifungals are likely adequate for the treatment of\n              <jats:italic>Candida<\/jats:italic>\n              endophthalmitis, newer antifungal agents also can be considered.\n            <\/jats:p>\n            <jats:p>\n              <jats:bold>\n                [\n                <jats:italic>Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n                . 2019;50:S13\u2013S17.]\n              <\/jats:bold>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/23258160-20190108-04","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T16:18:49Z","timestamp":1558109929000},"source":"Crossref","is-referenced-by-count":2,"title":["In Vitro Susceptibilities of Vitreous\n            <i>Candida<\/i>\n            Endophthalmitis Isolates to Newer and Traditional Antifungal Agents"],"prefix":"10.3928","volume":"50","author":[{"given":"Kenneth C.","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan F.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darlene","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Harry W.","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","first-page":"123","article-title":"Spectrum of aetiological agents of postoperative endophthalmitis and antibiotic susceptibility of bacterial isolates","volume":"48","author":"Anand AR","year":"2000","unstructured":"Anand AR, Therese KL, Madhavan HN. Spectrum of aetiological agents of postoperative endophthalmitis and antibiotic susceptibility of bacterial isolates. Indian J Ophthalmol. 2000;48:123\u2013128.","journal-title":"Indian J Ophthalmol"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00113-16"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.3928\/1542-8877-19970301-03"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.02.027"},{"key":"e_1_3_1_6_2","first-page":"183","article-title":"A comparative clinicopathologic study of endogenous mycotic endophthalmitis: variations in clinical and histopathologic changes in candidiasis compared to aspergillosis","volume":"98","author":"Rao NA","year":"2000","unstructured":"Rao NA, Hidayat A. A comparative clinicopathologic study of endogenous mycotic endophthalmitis: variations in clinical and histopathologic changes in candidiasis compared to aspergillosis. 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