{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T21:25:12Z","timestamp":1746653112239},"reference-count":16,"publisher":"SLACK, Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>The histologic findings of a subretinal band and epiretinal membrane (ERM) excised from two patients who developed retinal detachments (RDs) after non-U.S. Food and Drug Administration-regulated intravitreal \u201cstem cell\u201d injections are reported. Both membranes were composed of fibrocellular tissue that stained positively with Smooth Muscle Actin and Masson's trichrome, consistent with collagenous and smooth muscle composition. CD34 immunostain (for hematopoietic cells) was negative for the subretinal band and minimally positive for the ERM. The authors speculate that the \u201cstem cells\u201d may cause RDs by differentiation into myofibroblasts that cause tractional membranes, though further studies are warranted.<\/jats:p>\n          <jats:p>\n            <jats:bold>\n              [\n              <jats:italic>Ophthalmic Surg Lasers Imaging Retina.<\/jats:italic>\n              2019;50:125\u2013131.]\n            <\/jats:bold>\n          <\/jats:p>","DOI":"10.3928\/23258160-20190129-11","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T16:37:48Z","timestamp":1550248668000},"page":"125-131","source":"Crossref","is-referenced-by-count":5,"title":["Clinicopathologic Correlations of Retinal Membranes Associated With Intravitreal \u2018Stem Cell\u2019 Injections"],"prefix":"10.3928","volume":"50","author":[{"given":"Rehan M.","family":"Hussain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander R.","family":"Dubovy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay E.","family":"Kuriyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Harry W.","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Albini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.2217\/rme.15.10"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609583"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20160601-16"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20170829-16"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.5453"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000327"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2012.0637"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.12.006"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000488931"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15415"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181f9c242"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61376-3"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20636"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(82)90238-0"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0342"},{"issue":"9","key":"e_1_3_1_17_2","first-page":"3475","article-title":"Immunolocalization of integrins in proliferative retinal membranes","volume":"35","author":"Robbins SG","year":"1994","unstructured":"Robbins SG, Brem RB, Wilson DJ, et al. 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