{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:11:17Z","timestamp":1773033077476,"version":"3.50.1"},"reference-count":8,"publisher":"SLACK, Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Hydration of retinal tissue has been proposed as a potential model of macular hole (MH) formation in addition to tractional forces of the vitreous and internal limiting membrane (ILM). Carbonic anhydrase inhibitors have previously been utilized in the treatment of cystoid macular edema in outer retinal diseases. There has been recent interest in the use of topical aqueous suppression as a potential medical therapy for MHs. In this case series, four eyes with small (&lt; 300 \u03bcm) full-thickness MHs were treated with topical dorzolamide-timolol for 1 month. Two eyes achieved closure of the MH without surgical intervention, whereas the other two required pars plana vitrectomy with ILM peel. Future studies are required to investigate the role of topical aqueous suppression in the management of MHs.<\/jats:p>\n          <jats:p>\n            <jats:bold>\n              [\n              <jats:italic>Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n              . 2019;50:e38\u2013e43.]\n            <\/jats:bold>\n          <\/jats:p>","DOI":"10.3928\/23258160-20190129-17","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T16:38:37Z","timestamp":1550248717000},"source":"Crossref","is-referenced-by-count":18,"title":["Topical Aqueous Suppression and Closure of Idiopathic Full-Thickness Macular Holes"],"prefix":"10.3928","volume":"50","author":[{"given":"Daniel","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Obeid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"issue":"6","key":"e_1_3_1_2_2","first-page":"629","article-title":"Idiopathic senile macular hole: Its early stages and pathogenesis. 1988","volume":"23","author":"Gass JD","year":"2003","unstructured":"Gass JD. Idiopathic senile macular hole: Its early stages and pathogenesis. 1988. Retina. 2003;23(6 Suppl):629\u2013639.","journal-title":"Retina"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200306000-00028"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-10-24"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2017.09.009"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199717030-00009"},{"issue":"1","key":"e_1_3_1_7_2","first-page":"121","article-title":"Enhancement of retinal adhesion and subretinal fluid resorption by acetazolamide","volume":"23","author":"Marmor MF","year":"1982","unstructured":"Marmor MF, Maack T. Enhancement of retinal adhesion and subretinal fluid resorption by acetazolamide. Invest Ophthalmol Vis Sci. 1982;23(1):121\u2013124.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101206010073"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090200057022"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/23258160-20190129-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T04:46:06Z","timestamp":1683089166000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/23258160-20190129-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.3928\/23258160-20190129-17"],"URL":"https:\/\/doi.org\/10.3928\/23258160-20190129-17","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}