{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T04:15:27Z","timestamp":1683173727030},"reference-count":17,"publisher":"SLACK, Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Coats' disease is nonhereditary retinal vascular disorder characterized by telangiectatic retinal vessels with prominent aneurysmal changes and exudation. A conclusive etiology has not yet been determined. In this retrospective case report and literature review, a 64-year-old male with Dubin-Johnson syndrome presented with unilateral retinal vascular changes and exudation consistent with a diagnosis of adult Coats' disease. The authors conclude that patients with Dubin-Johnson syndrome carry mutations in a multidrug resistance associated protein (MRP). MRPs are also expressed in the retina, retinal pigment epithelium, and vascular endothelium, where they export toxins and metabolites, and may serve as a therapeutic target.<\/jats:p>\n          <jats:p>\n            <jats:bold>\n              [\n              <jats:italic>Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n              . 2019;50:318\u2013321.]\n            <\/jats:bold>\n          <\/jats:p>","DOI":"10.3928\/23258160-20190503-10","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T17:20:06Z","timestamp":1558113606000},"page":"318-321","source":"Crossref","is-referenced-by-count":0,"title":["Adult Coats' Disease, Dubin-Johnson Syndrome, and the Search for Targeted Therapies"],"prefix":"10.3928","volume":"50","author":[{"given":"Omar","family":"Moinuddin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward H.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly A.","family":"Drenser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1985.01050110089033"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73374-4"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-1194-x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000485"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.12.038"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(56)90002-2"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.67.11.766"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20100318-01"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.11.2031"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30420-X"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/302292"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-4-200102200-00029"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.149625"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.146381"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00240.2005"},{"key":"e_1_3_1_17_2","volume-title":"Syndromes: Rapid Recognition and Perioperative Implications","author":"Bissonnette B","year":"2006","unstructured":"Bissonnette B, Luginbuehl I, Marciniak B, Dalens B. Syndromes: Rapid Recognition and Perioperative Implications. New York, NY: McGraw-Hill; 2006."},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000878"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/23258160-20190503-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T06:51:21Z","timestamp":1683096681000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/23258160-20190503-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.3928\/23258160-20190503-10"],"URL":"https:\/\/doi.org\/10.3928\/23258160-20190503-10","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]}}}