{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:21:41Z","timestamp":1792844501747,"version":"4.5.0"},"reference-count":24,"publisher":"SLACK, Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND AND OBJECTIVE:<\/jats:title>\n            <jats:p>To describe a case series of three patients in one family with Von Hippel-Lindau (VHL) disease who presented with vitreoretinal neovascularization and resulting tractional retinal detachments (TRDs). This vitreoretinal phenotype of VHL may benefit from early surgical intervention.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS:<\/jats:title>\n            <jats:p>Descriptive case series of three patients in one family with VHL disease. A review of the literature regarding surgical intervention for VHL was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>All three patients developed prominent intravitreal neovascularization with fibrovascular growth within the vitreous secondary to a retinal capillary hemangioma. Two subjects with intravitreal neovascularization were treated with laser and cryotherapy but eventually developed a TRD. The final vision in these two patients was light perception and 20\/300. The eye that was preemptively treated with vitrectomy to remove the vitreous sustaining the neovascularization had visual acuity of 20\/50 after surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION:<\/jats:title>\n            <jats:p>Intravitreal neovascularization with fibrovascular proliferation may be an indication for vitrectomy prior to the development of retinal detachment.<\/jats:p>\n            <jats:p>\n              <jats:bold>\n                [\n                <jats:italic>Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n                . 2020;51:109\u2013115.]\n              <\/jats:bold>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/23258160-20200129-07","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T17:34:23Z","timestamp":1582306463000},"page":"109-115","source":"Crossref","is-referenced-by-count":4,"title":["Von Hippel-Lindau Syndrome Phenotype With Prominent Vitreoretinal Neovascularization Treated With Early PPV: A Case Series and Literature Review"],"prefix":"10.3928","volume":"51","author":[{"given":"Talhah","family":"Zubair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia F.","family":"Callaway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassie Ann","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A.","family":"Shields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco H.","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius M.","family":"Moshfeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"issue":"9","key":"e_1_3_1_2_2","first-page":"3067","article-title":"Retinal hemangioblastoma in von Hippel-Lindau disease: a clinical and molecular study","volume":"43","author":"Dollfus H","year":"2002","unstructured":"Dollfus H, Massin P, Taupin P, et al. Retinal hemangioblastoma in von Hippel-Lindau disease: a clinical and molecular study. Invest Ophthalmol Vis Sci. 2002;43(9):3067\u20133074. PMID:12202531","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.175"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/77.2.1151"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.03.009"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01177-6"},{"issue":"1","key":"e_1_3_1_7_2","first-page":"48","article-title":"Therapeutic options for capillary papillary hemangiomas","volume":"107","author":"Garcia-Arum\u00ed J","year":"2000","unstructured":"Garcia-Arum\u00ed J, Sararols LH, Cavero L, Escalada F, Corc\u00f3stegui BF. Therapeutic options for capillary papillary hemangiomas. Ophthalmology. 2000;107(1):48\u201354. PMID:10647718","journal-title":"Ophthalmology"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318030a290"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)98017-4"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.04.003"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200412000-00028"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.3.328"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01648-3"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200204000-00019"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(83)34481-X"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.127142"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1996.180"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30696-9"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/112067210101100414"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.9.1189"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.05.068"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.5.637"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.04.031"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000707"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001240"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/23258160-20200129-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T10:35:02Z","timestamp":1683110102000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/23258160-20200129-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.3928\/23258160-20200129-07"],"URL":"https:\/\/doi.org\/10.3928\/23258160-20200129-07","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}