{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:44:40Z","timestamp":1791989080219,"version":"4.4.0"},"reference-count":15,"publisher":"SLACK, Inc.","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"\n Background and Objective:<\/jats:title>\n This report aims to describe the clinical presentation, outcomes, and prognostic risk factors of toxic posterior segment syndrome (TPSS) associated with a compounded triamcinolone-moxifloxacin formulation administered during dropless cataract surgery (DLCS).<\/jats:p>\n <\/jats:sec>\n \n Patients and Methods:<\/jats:title>\n This was a retrospective multicenter case series of 50 eyes with TPSS after DLCS. Data collected included clinical and multi-modal imaging features. Multivariate and ordinal logistic regression models were used to identify factors associated with disease severity.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n TPSS severity was categorized as mild (\n n<\/jats:italic>\n = 14), moderate (\n n<\/jats:italic>\n = 14), or severe (\n n<\/jats:italic>\n = 22) based on final best-corrected visual acuity (BCVA). Severe cases demonstrated outer retinal thinning with ellipsoid zone (EZ) and external limiting membrane (ELM) loss, disc leakage, and enlarged foveal avascular zone. Ordinal logistic regression showed worse presenting visual acuity (< 20\/150; OR 7.00,\n P<\/jats:italic>\n < .001) and male sex predicted severe disease (OR 3.22,\n P<\/jats:italic>\n < .001), while a normal fluorescein angiography (FA) appearance was protective (coefficient \u22128.395,\n P<\/jats:italic>\n = .001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This large case series describes TPSS prognostic risk factors and underscores the urgent need for standardized Food and Drug Administration (FDA)\u2013approved intraocular formulations.<\/jats:p>\n <\/jats:sec>","DOI":"10.3928\/23258160-20260819-01","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:38:11Z","timestamp":1790123891000},"page":"625-632","source":"Crossref","is-referenced-by-count":0,"title":["Toxic Posterior Segment Syndrome Following Dropless Cataract Surgery With Compounded Triamcinolone-Moxifloxacin"],"prefix":"10.3928","volume":"57","author":[{"given":"Michael","family":"Yu","sequence":"first","affiliation":[{"name":"Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, Pennsylvania;"},{"name":"Byers Eye Institute, Stanford University, Palo Alto, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishan G.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Texas Southwestern Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil K.","family":"Bommakanti","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Anand","sequence":"additional","affiliation":[{"name":"Texas Retina Associates, Dallas, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah Y.","family":"Chong","sequence":"additional","affiliation":[{"name":"Texas Retina Associates, Dallas, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori E.","family":"Coors","sequence":"additional","affiliation":[{"name":"Texas Retina Associates, Dallas, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Fish","sequence":"additional","affiliation":[{"name":"Texas Retina Associates, Dallas, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Texas Retina Associates, Dallas, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Texas Retina Associates, Dallas, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yonekawa","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan M.","family":"Abbey","sequence":"additional","affiliation":[{"name":"Texas Retina Associates, Dallas, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2015.01.014"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.02.032"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.01.026"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.09.027"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2018.10.044"},{"key":"e_1_3_1_7_2","volume-title":"Package insert","year":"2019","unstructured":"Aprokam (cefuroxime). Package insert. Clermont-Ferrand: Laboratoires Th\u00e9a; 2019."},{"key":"e_1_3_1_8_2","volume-title":"Package insert","year":"2019","unstructured":"Dexycu (dexamethasone intraocular suspension). Package insert. EyePoint Pharmaceuticals Inc.; 2019."},{"key":"e_1_3_1_9_2","unstructured":"US Food and Drug Administration. FDA's investigation into Guardian's compounded triamcinolone\u2013moxifloxacin drug product. Published July 5 2018. Accessed 2025. https:\/\/web.archive.org\/web\/20260118235915\/https:\/\/www.fda.gov\/drugs\/human-drug-compounding\/fdas-investigation-guardians-compounded-triamcinolone-moxifloxacin-drug-product"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-19970701-16"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/10.1097\/IAE.0000000000002450"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.08.047"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/143564"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2010.02103.x"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.11.042"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2012.736547"}],"container-title":["Ophthalmic Surgery, Lasers and Imaging Retina"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:48:48Z","timestamp":1791985728000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/23258160-20260819-01"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.3928\/23258160-20260819-01"],"URL":"https:\/\/doi.org\/10.3928\/23258160-20260819-01","relation":{},"ISSN":["2325-8160","2325-8179"],"issn-type":[{"value":"2325-8160","type":"print"},{"value":"2325-8179","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}