{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:58:30Z","timestamp":1692439110055},"reference-count":24,"publisher":"SLACK, Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[1995,5,2]]},"abstract":"<jats:p>ABSTRACT<\/jats:p>\n          <jats:p>With the aim of reversing myopic regression laser photorefractive keratectomy (PRK) after excimer, the effect of high-dose topical corticosteroids in modulating changes in refraction and corneal transparency was assessed prospectively.<\/jats:p>\n          <jats:p>Twenty-four eyes of 23 patients (mean preoperative spherical equivalent refraction -7.36 diopters (D); range, -4.12 D to -19.25 D), demonstrating myopic regression ranging between 1.00 D and 6.88 D (mean: 2.64 D), were treated according to the same therapeutic protocol. Changes in corneal haze, corneal topography, and refraction were evaluated over 6 months.<\/jats:p>\n          <jats:p>Eighteen eyes (78.26%) showed 1.00 D or more reversal of myopic regression. Sixteen eyes (69.56%) regained the attempted correction present when corticosteroids were first stopped (\u00b11.00 D). The difference between mean refraction before reintroducing corticosteroids (-2.64 D; range, - 1.00 D to - 6.88 D) and when stabilization occurred (-0.60; range, + 1.50 D to -4.50 D) was stastisticaly significant (P&lt;0.01). The improvements in corneal haze and spectacle corrected visual acuity were also significant (both P&lt;0.01). Stabilization occurred between 1 to 4 months after surgery (mean, 2.22). In five eyes (21.74%) increased intraocular pressure of more than 20 mm Hg were reduced with betablockers.<\/jats:p>\n          <jats:p>Topical corticosteroid therapy can modulate refractive changes after PRK, appearing to reduce myopic regression. However, a longer follow up will be necessary to determine the final refractive outcome of these eyes. [J Refract Surg. 1995;11 (suppl.):S302-S308]<\/jats:p>","DOI":"10.3928\/1081-597x-19950502-24","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T05:42:41Z","timestamp":1619070161000},"source":"Crossref","is-referenced-by-count":5,"title":["Corticosteroids for Reversal of Myopic Regression After Photorefractive Keratectomy"],"prefix":"10.3928","volume":"11","author":[{"given":"Eduardo F","family":"Marques","sequence":"first","affiliation":[]},{"given":"Eugenio B","family":"Leite","sequence":"additional","affiliation":[]},{"given":"Jose G","family":"Cunha-Vaz","sequence":"additional","affiliation":[]}],"member":"2308","reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"crossref","unstructured":"1. Sexier T Holschbach A Derse M Jean B Genth U. Complications of myopic photorefractive keratectomy with the excimer laser. Ophthalmology. 1994;101:153-159.","DOI":"10.1016\/S0161-6420(94)31371-6"},{"key":"e_1_3_1_3_1","doi-asserted-by":"crossref","unstructured":"2. Gartry DS Kerr Muir MG Marshall J. Excimer laser photorefractive keratectomy: 18 month follow-up. Ophthalmology. 1992;99:1209-1219.","DOI":"10.1016\/S0161-6420(92)31821-4"},{"key":"e_1_3_1_4_1","doi-asserted-by":"crossref","unstructured":"3. Caubet E. Cause of subepithelial corneal haze over 18 months after photorefractive keratectomy for myopia. Refract Corneal Surg. 1993;9:65-70.","DOI":"10.3928\/1081-597X-19930302-18"},{"key":"e_1_3_1_5_1","doi-asserted-by":"crossref","unstructured":"4. Epstein D Tengroth B Fagerholm P Hamberg-Nystrom H. Excimer retreatment of regression after photorefractive keratectomy. Am J Ophthalmol. 1994;117:456-461.","DOI":"10.1016\/S0002-9394(14)70004-2"},{"key":"e_1_3_1_6_1","doi-asserted-by":"crossref","unstructured":"5. Gartry DS Kerr Muir MG Lohmann CP Marshall J. The effect of topical corticosteroids on refractive outcome and corneal haze after photorefractive keratectomy. Arch Ophthalmol. 1992;110:944-952.","DOI":"10.1001\/archopht.1992.01080190050028"},{"key":"e_1_3_1_7_1","doi-asserted-by":"crossref","unstructured":"6. Fitzsimmons Td Fagerholm P Tengroth B. Steroid treatment of myopic regression: acute refractive and topographic changes in excimer photorefractive keratectomy patients. Cornea. 1993;12:358-361.","DOI":"10.1097\/00003226-199307000-00013"},{"key":"e_1_3_1_8_1","doi-asserted-by":"crossref","unstructured":"7. Tengroth B Epstein D Fagerholm P Hamberg-Nystrom H Fitzsimmons TD. Excimer laser photorefractive keratectomy for myopia. Clinical results in sighted eyes. Ophthalmology. 1993;100:739-745.","DOI":"10.1016\/S0161-6420(93)31581-2"},{"key":"e_1_3_1_9_1","doi-asserted-by":"crossref","unstructured":"8. Gartry DS Kerr Muir MG Marshall J. The effect of topical corticosteroids on refraction and corneal haze following excimer laser treatment of myopia: an update. A prospective randomised double-masked study. Eye. 1993;7:584590.","DOI":"10.1038\/eye.1993.127"},{"key":"e_1_3_1_10_1","doi-asserted-by":"crossref","unstructured":"9. Lohmann CP Marshall J. Plasmin- and plasminogenactivator inhibitors after excimer laser photorefractive keratectomy: new concept in prevention of postoperative myopic regression and haze. Refract Corneal Surg. 1993;9:300-302.","DOI":"10.3928\/1081-597X-19930701-12"},{"key":"e_1_3_1_11_1","doi-asserted-by":"crossref","unstructured":"10. Morlet N Gillies MC Crouch K Mallof A. Effect of topical interferon-alfa-2b on corneal haze after excimer laser photorefractive keratectomy in rabbits. Refract Corneal Surg. 1993;9:443-451.","DOI":"10.3928\/1081-597X-19931101-08"},{"key":"e_1_3_1_12_1","doi-asserted-by":"crossref","unstructured":"11. Bergman RH Spigelman AV. The role of fibroblast inhibitors on corneal healing following photorefractive keratectomy with 193-nanometer excimer laser in rabbits. Ophthalmic Surg. 1994;25:170-174.","DOI":"10.3928\/1542-8877-19940301-10"},{"key":"e_1_3_1_13_1","doi-asserted-by":"crossref","unstructured":"12. Fagerholm P Hamberg-Nystrom H Tengroth B Epstein D. Effect of postoperative corticosteroids on the refractive outcome of photorefractive keratectomy for myopia with the Summit excimer laser. J Cataract Refract Surg. 1994;20(S):212-215.","DOI":"10.1016\/S0886-3350(13)80755-9"},{"key":"e_1_3_1_14_1","doi-asserted-by":"crossref","unstructured":"13. Epstein D Tengroth B Fagerholm P Hamberg-Nystrom H. Excimer PRK for myopia (letter). Ophthalmology. 1993;100:1605-1606.","DOI":"10.1016\/S0161-6420(93)31431-4"},{"key":"e_1_3_1_15_1","unstructured":"14. Leite E Tavares C Cardoso E Van Velze R. Fotoqueratectomia por laser excimer: Primeiros resultados. IOLAB\/S.P.O. Award. 1992."},{"key":"e_1_3_1_16_1","unstructured":"15. Waring GO III. Development of a system for excimer laser corneal surgery. Tr Am Ophth Soc. 1989;87:854-963."},{"key":"e_1_3_1_17_1","doi-asserted-by":"crossref","unstructured":"16. Tengroth B Fagerholm P Soderberg P Hamberg-Nystrom H Epstein D. Effect of corticosteroids in postoperative care following photorefractive keratectomies. Refract Corneal Surg. 1993;9:61-64.","DOI":"10.3928\/1081-597X-19930302-17"},{"key":"e_1_3_1_18_1","doi-asserted-by":"crossref","unstructured":"17. Hanna KD Pouliquen YM Waring GO HI Savoldelli M Fantes F Thompson KP. Corneal wound healing in monkeys after repeated excimer laser photorefractive keratectomy. Arch Ophthalmol. 1992;110:1286-1291.","DOI":"10.1001\/archopht.1992.01080210104035"},{"key":"e_1_3_1_19_1","doi-asserted-by":"crossref","unstructured":"18. Sundar Raj N Geiss MJ Fantes F et al. Healing of excimer laser ablated monkey corneas. Arch Ophthalmol. 1990;108:1604-1610.","DOI":"10.1001\/archopht.1990.01070130106039"},{"key":"e_1_3_1_20_1","doi-asserted-by":"crossref","unstructured":"19. Marshall J Trokel S Rothery S Krueger R. Long term healing of the central cornea after photorefractive keratectomy using an excimer laser. Ophthalmology. 1988;95:14111421.","DOI":"10.1016\/S0161-6420(88)32997-0"},{"key":"e_1_3_1_21_1","doi-asserted-by":"crossref","unstructured":"20. Carones F Brancate R Venturi E Scialdone A Bertuzzi A Tavola A. Efficacy of corticosteroids in reversing regression after myopic photorefractive keratectomy. Refract Corneal Surg. 1993;9:52-56.","DOI":"10.3928\/1081-597X-19930302-16"},{"key":"e_1_3_1_22_1","doi-asserted-by":"crossref","unstructured":"21. Lohmann CP Gartry DS Kerr Muir MG Timberlake GT Fitzke FW Marshall J Corneal haze after excimer laser refractive surgery: objective measurements and functional implications. Eur J Ophthalmol. 1991;1:173-180.","DOI":"10.1177\/112067219100100403"},{"key":"e_1_3_1_23_1","unstructured":"22. Fitzsimmons TD Fagerholm P Harfstrand A Schenholm M. Hyaluronic acid in the rabbit cornea after excimer laser superficial keratectomy. Invest Ophthalmol Vis Sci. 1992;33:3011-3016."},{"key":"e_1_3_1_24_1","unstructured":"23. Fitzsimmons TD Fagerholm P Harfstrand A1 Schenholm M. Steroids after excimer surgery decrease corneal hyaluronic acid content. Invest Ophthalmol Vis Sci. 1992;33(suppL):766-77l."},{"key":"e_1_3_1_25_1","unstructured":"24. FitzBinmlons PD Molander N Stenevi U Fagerhaim P Schenholm M Vbn Malmborg A. Endogenous hyaiuronan in corneal disease. 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