{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:41:51Z","timestamp":1759333311035},"reference-count":20,"publisher":"SLACK, Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Refract Surg"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE:<\/jats:title>\n            <jats:p>To evaluate the efficacy and safety of keratoconus refractive and visual improvement by combined intracorneal ring segments (ICRS; Intacs\/Intacs SK, Addition Technology Inc., Des Moines, IL) and phakic intraocular lens (PIOL; Artisan\/Artiflex Toric IOL, Ophtec BV, Groningen, Holland) implantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>This study comprised patients who had ICRS implantation followed by PIOL implantation 6 or more months later for the correction of keratoconus. Over a 12-month follow-up after PIOL implantation, the main outcome measures were uncorrected and corrected distance visual acuity (UDVA and CDVA), spherical equivalent refraction, and central endothelial cell density. Efficacy and safety indexes were calculated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              The study included 21 eyes of 16 patients. The mean UDVA 12 months after ICRS and PIOL implantation increased from 2.0 \u00b1 0 to 0.25 \u00b1 0.22 logMAR (Snellen 20\/2000 to 20\/35) (\n              <jats:italic>P<\/jats:italic>\n              &lt; .001). The mean CDVA increased from 0.31 \u00b1 0.13 to 0.13 \u00b1 0.13 log-MAR (Snellen 20\/40 to 20\/25) (\n              <jats:italic>P<\/jats:italic>\n              = .039). Predictability of refractive results was good, with spherical equivalent refraction within \u00b10.50 diopter of the attempted correction in 13 eyes (61.9%) and within \u00b11.00 diopter in 19 eyes (90.5%). Mean central endothelial cell density decreased from 2,513 \u00b1 245 cells\/mm\n              <jats:sup>2<\/jats:sup>\n              preoperatively to 2,312 \u00b1 263 cells\/mm\n              <jats:sup>2<\/jats:sup>\n              (\n              <jats:italic>P<\/jats:italic>\n              = .402). The efficacy index was 1.06 and the safety index was 1.40.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Keratoconus visual and refractive improvement by the sequential implantation of Intacs ICRS and Artisan\/Artiflex Toric IOL is a safe and predictable procedure.<\/jats:p>\n            <jats:p>\n              <jats:bold>\n                [\n                <jats:italic>J Refract Surg.<\/jats:italic>\n                2014;30(5):336\u2013341.]\n              <\/jats:bold>\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.3928\/1081597x-20140319-01","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T12:33:25Z","timestamp":1407760405000},"page":"336-341","source":"Crossref","is-referenced-by-count":27,"title":["Combined Intracorneal Ring Segments and Iris-Fixated Phakic Intraocular Lens for Keratoconus Refractive and Visual Improvement"],"prefix":"10.3928","volume":"30","author":[{"given":"Tiago Bravo","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"Jos\u00e9 Luis","family":"G\u00fcell","sequence":"additional","affiliation":[]},{"given":"Felicidad","family":"Manero","sequence":"additional","affiliation":[]}],"member":"2308","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(84)90094-8"},{"key":"e_1_3_2_3_2","first-page":"164","article-title":"Automated topographic screening for keratoconus in refractive surgery candidates","volume":"22","author":"Kalin NS","year":"1996","unstructured":"Kalin NS, Maeda N, Klyce SD, Hargrave S, Wilson SE. Automated topographic screening for keratoconus in refractive surgery candidates. CLAO J. 1996;22:164\u2013167.","journal-title":"CLAO J"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700061"},{"key":"e_1_3_2_5_2","first-page":"1923","article-title":"Photorefractive keratectomy in patients with mild to moderate stable keratoconus: a five-year prospective follow-up study","volume":"7","author":"Chelala E","year":"2013","unstructured":"Chelala E, Rami HE, Dirani A, Fadlallah A, Fakhoury O, Warrak E. Photorefractive keratectomy in patients with mild to moderate stable keratoconus: a five-year prospective follow-up study. Clin Ophthalmol. 2013;7:1923\u20131928.","journal-title":"Clin Ophthalmol"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.10.021"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2011.08.026"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.02.048"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31825ca70b"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.01.064"},{"key":"e_1_3_2_11_2","first-page":"9","article-title":"Four-year follow up of intrastromal corneal ring segments in patients with keratoconus","volume":"1","author":"G\u00fcell JL","year":"2010","unstructured":"G\u00fcell JL, Morral M, Salinas C, Elies D, Gris O, Manero F. Four-year follow up of intrastromal corneal ring segments in patients with keratoconus. Journal of Emmetropia. 2010;1:9\u201315.","journal-title":"Journal of Emmetropia"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.01.019"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.07.040"},{"key":"e_1_3_2_14_2","first-page":"2537","article-title":"Baseline findings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study","volume":"39","author":"Zadnik K","year":"1998","unstructured":"Zadnik K, Barr JT, Edrington TB, et al. Baseline findings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. Invest Ophthalmol Vis Sci. 1998;39:2537\u20132546.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000020"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2011.10.031"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(02)01618-8"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.07.021"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.12.059"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181eeb0dd"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20100407-01"}],"container-title":["Journal of Refractive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.healio.com\/doiresolver?doi=10.3928\/1081597X-20140319-01","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T13:24:42Z","timestamp":1683120282000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.healio.com\/doi\/10.3928\/1081597X-20140319-01"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.3928\/1081597X-20140319-01"],"URL":"https:\/\/doi.org\/10.3928\/1081597x-20140319-01","relation":{},"ISSN":["1081-597X"],"issn-type":[{"value":"1081-597X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}