{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:55:00Z","timestamp":1774414500802,"version":"3.50.1"},"reference-count":31,"publisher":"SLACK, Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Surg Lasers Imaging Retina"],"published-print":{"date-parts":[[2020,3]]},"abstract":"\n BACKGROUND AND OBJECTIVE:<\/jats:title>\n To compare complete internal limiting membrane (ILM) peeling with the inverted flap technique for macular hole (MH) surgery.<\/jats:p>\n <\/jats:sec>\n \n PATIENTS AND METHODS:<\/jats:title>\n \n An electronic database search on PubMed, CENTRAL, and\n ClinicalTrials.gov<\/jats:ext-link>\n was performed. Inclusion criteria were comparative prospective\/retrospective studies including patients with MH of any size with at least 6 months of follow-up. The primary outcome was MH closure rate. Secondary outcomes were best-corrected visual acuity improvement and surgery-related adverse events.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Sixteen papers enrolling 1,403 eyes were included (733 ILM peeling, 670 inverted flap). MH mean minimum diameter and time of symptomatic evolution were higher in the inverted flap group (531.1 \u03bcm \u00b1 188.8 \u03bcm vs. 602.8 \u03bcm \u00b1 223.8 \u03bcm; 10.4 \u00b1 20.2 months vs. 12.0 \u00b1 18.4 months;\n P<\/jats:italic>\n < .01). Overall, MH closure rate was superior with the inverted flap technique (risk-ratio [RR]: 1.25; 95% confidence interval [CI], 1.14\u20131.38;\n P<\/jats:italic>\n < .0001), as well as in all subgroups: idiopathic large MH (n = 362; RR: 1.12; 95% CI, 1.05\u20131.20;\n P<\/jats:italic>\n < .001), myopic MH without retinal detachment (n = 133; RR: 1.35; 95% CI, 1.14\u20131.59;\n P<\/jats:italic>\n < .001), and MH retinal detachment (n = 198; RR: 1.89; 95% CI, 1.31\u20132.73;\n P<\/jats:italic>\n < .001).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n This meta-analysis suggests the inverted flap technique is more effective in achieving MH closure.<\/jats:p>\n \n \n [\n Ophthalmic Surg Lasers Imaging Retina<\/jats:italic>\n . 2020;51:187\u2013195.]\n <\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3928\/23258160-20200228-08","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T17:58:58Z","timestamp":1585159138000},"page":"187","source":"Crossref","is-referenced-by-count":34,"title":["Complete ILM Peeling Versus Inverted Flap Technique for Macular Hole Surgery: A Meta-Analysis"],"prefix":"10.3928","volume":"51","author":[{"given":"Raquel Esteves","family":"Marques","sequence":"first","affiliation":[]},{"given":"David Cordeiro","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"Leal","sequence":"additional","affiliation":[]},{"given":"Mun Yueh","family":"Faria","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Marques-Neves","sequence":"additional","affiliation":[]}],"member":"2308","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.01.052"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6287"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2016.07.003"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.02.011"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001211"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002368"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_3_1_10_2","unstructured":"Wells GA Shea B O'Connell D et al. 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