{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T20:17:17Z","timestamp":1723061837944},"reference-count":100,"publisher":"American Institute of Mathematical Sciences (AIMS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MBE"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p xml:lang=\"fr\">&lt;abstract&gt;&lt;p&gt;In this study we review the current state of the art for Dupuytren's disease (DD), while emphasising the need for a better integration of clinical, experimental and quantitative predictive approaches to understand the evolution of the disease and improve current treatments. We start with a brief review of the biology of this disease and current treatment approaches. Then, since certain aspects in the pathogenesis of this disorder have been compared to various biological aspects of wound healing and malignant processes, next we review some &lt;italic&gt;in silico&lt;\/italic&gt; (mathematical modelling and simulations) predictive approaches for complex multi-scale biological interactions occurring in wound healing and cancer. We also review the very few &lt;italic&gt;in silico&lt;\/italic&gt; approaches for DD, and emphasise the applicability of these approaches to address more biological questions related to this disease. We conclude by proposing new mathematical modelling and computational approaches for DD, which could be used in the absence of animal models to make qualitative and quantitative predictions about the evolution of this disease that could be further tested &lt;italic&gt;in vitro&lt;\/italic&gt;.&lt;\/p&gt;&lt;\/abstract&gt;<\/jats:p>","DOI":"10.3934\/mbe.2022132","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T09:54:21Z","timestamp":1642413261000},"page":"2876-2895","source":"Crossref","is-referenced-by-count":3,"title":["Quantitative predictive approaches for Dupuytren disease: a brief review and future perspectives"],"prefix":"10.3934","volume":"19","author":[{"given":"Georgiana","family":"Eftimie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Clinique de la Miotte, Avenue de la Miotte, Belfort 90000, France","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca","family":"Eftimie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Laboratoire Math\u00e9matiques de Besan\u00e7on, UMR - CNRS 6623 Universit\u00e9 de Bourgogne Franche-Comt\u00e9, Besan\u00e7on 25000, France","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2321","reference":[{"key":"key-10.3934\/mbe.2022132-1","doi-asserted-by":"publisher","unstructured":"C. Ball, D. Izadi, L. Verjee, J. Chan, J. Nanchahal, Systematic review of non-surgical treatments for early Dupuytren's disease,  <i>BMC Musculoskeletal Disord.<\/i>,  <b>17<\/b> (2016), 345. https:\/\/doi.org\/10.1186\/s12891-016-1200-y","DOI":"10.1186\/s12891-016-1200-y"},{"key":"key-10.3934\/mbe.2022132-2","doi-asserted-by":"publisher","unstructured":"R. Grazina, S. Teixeira, R. Ramos, H. Sousa, A. Ferreira, R. Lemos, Dupuytren's disease: where do we stand?,  <i>EFORT Open Rev.<\/i>,  <b>4<\/b> (2019), 63\u201369. https:\/\/doi.org\/10.1302\/2058-5241.4.180021","DOI":"10.1302\/2058-5241.4.180021"},{"key":"key-10.3934\/mbe.2022132-3","doi-asserted-by":"publisher","unstructured":"G. Rayan, Dupuytren disease: anatomy, pathology, presentation, and treatment,  <i>J. Bone Joint Surg.<\/i>,  <b>89<\/b> (2007), 190\u2013198. https:\/\/doi.org\/10.2106\/00004623-200701000-00026","DOI":"10.2106\/00004623-200701000-00026"},{"key":"key-10.3934\/mbe.2022132-4","unstructured":"C. Eaton, <i>Dupuytren disease and related diseases - The cutting edge<\/i>, Springer International Publishing Switzerland, 2017. https: \/\/doi.org\/10.1007\/978-3-319-32199-8"},{"key":"key-10.3934\/mbe.2022132-5","doi-asserted-by":"publisher","unstructured":"R.B. Shaw. Jr., A.K.S. Chong, A. Zhang, V. R. Hentz, J. Chang, Dupuytren's disease: history, diagnosis, and treatment,  <i>Plast. Reconstr. Surg.<\/i>,  <b>120<\/b> (2007), 44e. https:\/\/doi.org\/10.1016\/s0363-5023(10)80134-0","DOI":"10.1016\/s0363-5023(10)80134-0"},{"key":"key-10.3934\/mbe.2022132-6","doi-asserted-by":"publisher","unstructured":"R. McFarlane, Dupuytren's disease: Relation to work and injury,  <i>J. Hand Surg. Am.<\/i>,  <b>16<\/b> (1991), 775\u2013779. https:\/\/doi.org\/10.1016\/s0363-5023(10)80134-0","DOI":"10.1016\/s0363-5023(10)80134-0"},{"key":"key-10.3934\/mbe.2022132-7","doi-asserted-by":"publisher","unstructured":"E. Critchley, S. Vakil, H. Hayward, V. Owen, Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants,  <i>J. Neurol. Neurosurg. Psychiatry<\/i>,  <b>39<\/b> (1976), 498\u2013503. https:\/\/doi.org\/10.1136\/jnnp.39.5.498","DOI":"10.1136\/jnnp.39.5.498"},{"key":"key-10.3934\/mbe.2022132-8","doi-asserted-by":"publisher","unstructured":"P. Burge, G. Hoy, P. Regan, R. Milne, Smoking, alcohol and the risk of Dupuytren's contracture,  <i>J. Bone Joint Surg. Br.<\/i>,  <b>79<\/b> (1997), 206\u2013210. https:\/\/doi.org\/10.1302\/0301-620x.79b2.6990","DOI":"10.1302\/0301-620x.79b2.6990"},{"key":"key-10.3934\/mbe.2022132-9","unstructured":"K. Denkler, Surgical complications associated with fascietomy for Dupuytren's disease: A 20-year review of the English literature,  <i>Eplasty<\/i>,  <b>10<\/b> (2010), e15."},{"key":"key-10.3934\/mbe.2022132-10","doi-asserted-by":"publisher","unstructured":"H. Khan, F. Verrijp, S. Hovius, C. van Nieuwenhoven, D. D. Group, R. Selles, Recurrence of Dupuytren's contracture: a consensus-based definition,  <i>PLoS One<\/i>,  <b>12<\/b> (2017), e0164849. https:\/\/doi.org\/10.1371\/journal.pone.0164849","DOI":"10.1371\/journal.pone.0164849"},{"key":"key-10.3934\/mbe.2022132-11","doi-asserted-by":"publisher","unstructured":"R. Meek, S. McLellan, J. Crossan, Dupuytren's disease: A model for the mechanisms of fibrosis and its modulation by steroids,  <i>J. Bone Joint Surg. Br.<\/i>,  <b>81<\/b> (1999), 732\u2013738. https:\/\/doi.org\/10.1302\/0301-620x.81b4.9163","DOI":"10.1302\/0301-620x.81b4.9163"},{"key":"key-10.3934\/mbe.2022132-12","doi-asserted-by":"publisher","unstructured":"L. Verjee, J. Verhoekx, J. Chan, T. Krausgruber, V. Nicolaidou, D. Izadi, et al., Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target,  <i>Proc. Natl. Acad. Sci. USA<\/i>,  <b>110<\/b> (2013), E928\u2013E937. https:\/\/doi.org\/10.1073\/pnas.1301100110","DOI":"10.1073\/pnas.1301100110"},{"key":"key-10.3934\/mbe.2022132-13","doi-asserted-by":"publisher","unstructured":"S. Iqbal, M. Hayton, J. Watson, P. Szczypa, A. Bayat, First identification of resident and circulating fibrocytes in Dupuytren's disease shown to be inhibited by Serum Amyloid P and Xiapex,  <i>PLoS One<\/i>,  <b>9<\/b> (2014), e99967. https:\/\/doi.org\/10.1371\/journal.pone.0099967","DOI":"10.1371\/journal.pone.0099967"},{"key":"key-10.3934\/mbe.2022132-14","doi-asserted-by":"publisher","unstructured":"J. Neum\u00fcller, J. Menzel, H. Millesi, Prevalence of HLA-DR3 and autoantibodies to connective tissue components in Dupuytren's contracture, <i>Clin. Immunol. Immunopathol.<\/i>, <b>71<\/b> (1994), 142\u2013148. https:\/\/doi.org\/10.1006\/clin.1994.1064","DOI":"10.1006\/clin.1994.1064"},{"key":"key-10.3934\/mbe.2022132-15","doi-asserted-by":"publisher","unstructured":"R. Pereira, C. Black, S. Turner, J. Spencer, Antibodies to collagen types I-VI in Dupuytren's contracture,  <i>J. Hand Surg. Br.<\/i>,  <b>11<\/b> (1986), 58\u201360. https:\/\/doi.org\/10.1016\/0266-7681(86)90014-8","DOI":"10.1016\/0266-7681(86)90014-8"},{"key":"key-10.3934\/mbe.2022132-16","doi-asserted-by":"publisher","unstructured":"J. Wilkinson, R. Davidson, T. Swingler, E. Jones, A. Corps and P. Johnston, et al., MMP-14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction, <i>Biochim. Biophys. Acta<\/i>, <b>1822<\/b> (2012), 897\u2013905. https:\/\/doi.org\/10.1016\/j.bbadis.2012.02.001","DOI":"10.1016\/j.bbadis.2012.02.001"},{"key":"key-10.3934\/mbe.2022132-17","doi-asserted-by":"publisher","unstructured":"B. Costas, S. Coleman, G. Kaufman, R. James, B. Cohen, R. Gaston, Efficacy and safety of collagenase clostridium histolyticum for Dupuytren disease nodules: a randomized controlled trial,  <i>BMC Musculoskeletal Disord.<\/i>,  <b>18<\/b> (2017), 374. https:\/\/doi.org\/10.1186\/s12891-017-1713-z","DOI":"10.1186\/s12891-017-1713-z"},{"key":"key-10.3934\/mbe.2022132-18","doi-asserted-by":"publisher","unstructured":"G. Caravalhana, I. Auquit-Auckbur, P. Y. Miliez, Maladie de Dupuytren : \u00e9tat des connaissances et de la recherche en physiopathologie, <i>Chirurgie de la Main<\/i>, <b>30<\/b> (2011), 239\u2013245. https:\/\/doi.org\/10.1016\/j.main.2011.03.002","DOI":"10.1016\/j.main.2011.03.002"},{"key":"key-10.3934\/mbe.2022132-19","doi-asserted-by":"publisher","unstructured":"K. Gudmunsson, R. Amgrimsson, N. Sigf\u00fasson, T. J\u00f3nsson, Increased total mortality and cancer mortality in men with Dupuytren's disease: a 15-year follow-up study, <i>J. Clin. Epidem.<\/i>, <b>55<\/b> (2002), 5\u201310. https:\/\/doi.org\/10.1016\/s0895-4356(01)00413-9","DOI":"10.1016\/s0895-4356(01)00413-9"},{"key":"key-10.3934\/mbe.2022132-20","doi-asserted-by":"publisher","unstructured":"S. Karkampouna, P. Kloen, M. Obdejin, S. Riester, A. van Wijnen, M. K. de Julio, Human Dupuytren's <i>ex vivo<\/i> culture for the study of myofibroblasts and extracellular matrix interactions, <i>J. Vis. Exp.<\/i>, <b>98<\/b> (2015), 52534. https:\/\/doi.org\/10.3791\/52534","DOI":"10.3791\/52534"},{"key":"key-10.3934\/mbe.2022132-21","doi-asserted-by":"publisher","unstructured":"S. Ud-Din, A. Bayat, Non-animal models of wound healing in cutaneous repair: <i>in silico<\/i>,  <i>in vitro<\/i>,  <i>ex vivo<\/i>, and <i>in vivo<\/i> models of wounds and scars in human skin,  <i>Wound Repair Regen.<\/i>,  <b>25<\/b> (2017), 164\u2013176. https:\/\/doi.org\/10.1111\/wrr.12513","DOI":"10.1111\/wrr.12513"},{"key":"key-10.3934\/mbe.2022132-22","doi-asserted-by":"publisher","unstructured":"C. Jean-Quartier, F. Jeanquartier, I. Jurisica, A. Holzinger,  <i>In silico<\/i> cancer research towards 3R,  <i>BMC Cancer<\/i>,  <b>18<\/b> (2018), 408. https:\/\/doi.org\/10.1186\/s12885-018-4302-0","DOI":"10.1186\/s12885-018-4302-0"},{"key":"key-10.3934\/mbe.2022132-23","doi-asserted-by":"publisher","unstructured":"N. Menke, J. Cain, A. Reynolds, D. Chan, R. Segal, T. W. Witten, et al., An <i>in silico<\/i> approach to the analysis of acute wound healing,  <i>Wound Repair Regen.<\/i>,  <b>18<\/b> (2010), 105\u2013113. https:\/\/doi.org\/10.1111\/j.1524-475X.2009.00549.x","DOI":"10.1111\/j.1524-475X.2009.00549.x"},{"key":"key-10.3934\/mbe.2022132-24","doi-asserted-by":"publisher","unstructured":"C. A. Alfonso-Rodr\u00edguez, I. Garz\u00f3n, J. Garrido-G\u00f3mez, A. C. X. Oliveira, M. A. Mart\u00edn-Piedra, G. Scionti, et al., Identification of histological patterns in clinically affected and unaffected palm regions in Dupuytren's disease,  <i>PLoS One<\/i>,  <b>9<\/b> (2014), e112457. https:\/\/doi.org\/10.1371\/journal.pone.0112457","DOI":"10.1371\/journal.pone.0112457"},{"key":"key-10.3934\/mbe.2022132-25","doi-asserted-by":"publisher","unstructured":"S. Rehman, Y. Xu, W. Dunn, P. Day, H. Westerhoff, R. Goodacre, et al., Dupuytren's disease metabolite analyses reveals alterations following initial short-term fibroblast culturing,  <i>Mol. BioSyst.<\/i>,  <b>8<\/b> (2012), 2274\u20132288. https:\/\/doi.org\/10.1039\/c2mb25173f","DOI":"10.1039\/c2mb25173f"},{"key":"key-10.3934\/mbe.2022132-26","doi-asserted-by":"crossref","unstructured":"J. Luck, Dupuytren's contracture: a new concept of the pathogenesis correlated with surgical management,  <i>J. Bone Joint Surg.<\/i>,  <b>41<\/b> (1959), 635\u2013664.","DOI":"10.2106\/00004623-195941040-00008"},{"key":"key-10.3934\/mbe.2022132-27","doi-asserted-by":"publisher","unstructured":"T. Layton, J. Hanchahal, Recent advanced in the understanding of Dupuytren's disease,  <i>F1000Res<\/i>,  <b>8<\/b> (2019), 231. https:\/\/doi.org\/10.12688\/f1000research.17779.1","DOI":"10.12688\/f1000research.17779.1"},{"key":"key-10.3934\/mbe.2022132-28","doi-asserted-by":"publisher","unstructured":"K. Moyer, D. Banducci, W. Graham, H. Ehrlich, Dupuytren's disease: physiologic changes in nodule and cord fibroblasts through aging <i>in vitro<\/i>,  <i>Plast. Reconstr. Surg.<\/i>,  <b>110<\/b> (2002), 187\u2013196. https:\/\/doi.org\/10.1097\/00006534-200207000-00031","DOI":"10.1097\/00006534-200207000-00031"},{"key":"key-10.3934\/mbe.2022132-29","doi-asserted-by":"publisher","unstructured":"L. Vi, L. Feng, R. Zhu, Y. Wu, L. Satish, B. Gan, et al., Periostin differentially induces proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cells,  <i>Exp. Cell Res.<\/i>,  <b>315<\/b> (2009), 3574\u20133586. https:\/\/doi.org\/10.1016\/j.yexcr.2009.07.015","DOI":"10.1016\/j.yexcr.2009.07.015"},{"key":"key-10.3934\/mbe.2022132-30","doi-asserted-by":"publisher","unstructured":"M. van Beuge, E. J. ten Dam, P. Werker, R. Bank, Matrix and cell phenotype differences in Dupuytren's disease,  <i>Fibrogenesis Tissue Repair<\/i>,  <b>9<\/b> (2016), 9. https:\/\/doi.org\/10.1186\/s13069-016-0046-0","DOI":"10.1186\/s13069-016-0046-0"},{"key":"key-10.3934\/mbe.2022132-31","doi-asserted-by":"publisher","unstructured":"E. Bianchi, S. Taurone, L. Bardella, A. Signore, E. Pompili and V. Sessa, et al., Involvement of pro-inflammatory cytokines and growth factors in the pathogenesis of the Dupuytren's contracture: a novel target for a possible future therapeutic strategy?,  <i>Clin. Sci.<\/i>,  <b>129<\/b> (2015), 711\u2013720. https:\/\/doi.org\/10.1042\/CS20150088","DOI":"10.1042\/CS20150088"},{"key":"key-10.3934\/mbe.2022132-32","doi-asserted-by":"publisher","unstructured":"J. Verhoekx, K. Beckett, M. Bisson, D. McGrouther, A. Grobbelaar, V. Mudera, The mechanical environment in Dupuytren's contracture determines cell contractility and associated MMP-mediated matrix remodeling,  <i>J. Orthop. Res.<\/i>,  <b>31<\/b> (2013), 328\u2013334. https:\/\/doi.org\/10.1002\/jor.22220","DOI":"10.1002\/jor.22220"},{"key":"key-10.3934\/mbe.2022132-33","doi-asserted-by":"publisher","unstructured":"J. Andrew, S. Andrew, A. Ash, B. Turner, An investigation into the role of inflammatory cells in Dupuytren's disease,  <i>J. Hand Surg. Br.<\/i>,  <b>16<\/b> (1991), 267\u2013271. https:\/\/doi.org\/10.1016\/0266-7681(91)90051-o","DOI":"10.1016\/0266-7681(91)90051-o"},{"key":"key-10.3934\/mbe.2022132-34","doi-asserted-by":"publisher","unstructured":"C. Mayerl, B. D. Frari, W. Parson, G. Boeck, H. Piza-Katzer, G. Wick, et al., Characterisation of the inflammatory response in Dupuytren's disease,  <i>J. Plast. Surg. Hand Surg.<\/i>,  <b>50<\/b> (2016), 171\u2013179. https:\/\/doi.org\/10.3109\/2000656X.2016.1140054","DOI":"10.3109\/2000656X.2016.1140054"},{"key":"key-10.3934\/mbe.2022132-35","doi-asserted-by":"publisher","unstructured":"M. Tripoli, A. Cordova, F. Moschella, Updates on the role of molecular factors and fibroblasts in the pathogenesis of Dupuytren's disease,  <i>J. Cell Commun Signal.<\/i>,  <b>10<\/b> (2016), 315\u2013330. https:\/\/doi.org\/10.1007\/s12079-016-0331-0","DOI":"10.1007\/s12079-016-0331-0"},{"key":"key-10.3934\/mbe.2022132-36","doi-asserted-by":"crossref","unstructured":"T. Wynn, T. Ramalingam, Mechanisms of fibrosis: therapeutic translation for fibrotic disease,  <i>Nat. Med.<\/i>,  <b>18<\/b> (2012), 1028\u20131040. https:\/\/doi.org\/https:\/\/doi.org\/10.1038\/nm.2807","DOI":"10.1038\/nm.2807"},{"key":"key-10.3934\/mbe.2022132-37","doi-asserted-by":"publisher","unstructured":"L. Verjee, K. Midwood, D. Davidson, D. Essex, A. Sandison, J. Nanchahal, Myofibroblast distribution in Dupuytren's cords: correlation with digital contracture,  <i>J. Hand Surg. Am.<\/i>,  <b>34<\/b> (2009), 1785\u20131794. https:\/\/doi.org\/10.1016\/j.jhsa.2009.08.005","DOI":"10.1016\/j.jhsa.2009.08.005"},{"key":"key-10.3934\/mbe.2022132-38","doi-asserted-by":"publisher","unstructured":"B. Behm, P. Babilas, M. Landthaler, S. Schreml, Cytokines, chemokines and growth factors in wound healing,  <i>J. Eur. Acad. Dermatol Venerol<\/i>,  <b>26<\/b> (2012), 812\u2013820. https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04415.x","DOI":"10.1111\/j.1468-3083.2011.04415.x"},{"key":"key-10.3934\/mbe.2022132-39","doi-asserted-by":"publisher","unstructured":"G. Landskron, M. D. L. Fuente, P. Thuwajit, C. Tuwajit, M. Hermoso, Chronic inflammation and cytokines in the tumour microenvironment,  <i>J. Immunol. Res.<\/i>,  <b>2014<\/b> (2014), 149185. https:\/\/doi.org\/10.1155\/2014\/149185","DOI":"10.1155\/2014\/149185"},{"key":"key-10.3934\/mbe.2022132-40","doi-asserted-by":"publisher","unstructured":"K. Baird, J. Crossan, S. Ralston, Abnormal growth factor and cytokine expression in Dupuytren's contracture,  <i>J. Clin. Pathol.<\/i>,  <b>46<\/b> (1993), 425\u2013428. https:\/\/doi.org\/10.1136\/jcp.46.5.425","DOI":"10.1136\/jcp.46.5.425"},{"key":"key-10.3934\/mbe.2022132-41","doi-asserted-by":"publisher","unstructured":"K. Augoff, J. Kula, J. Gosk, R. Rutowski, Epidermal growth factor in Dupuytren's disease,  <i>Plast Reconstr. Surg.<\/i>,  <b>115<\/b> (2005), 128\u2013133. https:\/\/doi.org\/10.1097\/01.PRS.0000146038.61595.4A","DOI":"10.1097\/01.PRS.0000146038.61595.4A"},{"key":"key-10.3934\/mbe.2022132-42","doi-asserted-by":"publisher","unstructured":"K. Augoff, R. Tabola, J. Kula, J. Gosk, R. Rutowski, Epidermal growth factor receptor (EGF-R) in Dupuytren's disease,  <i>J. Hand Surg. Br.<\/i>,  <b>30<\/b> (2005), 570\u2013573. https:\/\/doi.org\/10.1016\/j.jhsb.2005.06.008","DOI":"10.1016\/j.jhsb.2005.06.008"},{"key":"key-10.3934\/mbe.2022132-43","doi-asserted-by":"publisher","unstructured":"S. Sigismund, D. Avanzato, L. Lanzetti, Emerging functions of the EGFR in cancer,  <i>Mol. Oncol.<\/i>,  <b>12<\/b> (2018), 3\u201320. https:\/\/doi.org\/10.1002\/1878-0261.12155","DOI":"10.1002\/1878-0261.12155"},{"key":"key-10.3934\/mbe.2022132-44","doi-asserted-by":"publisher","unstructured":"N. Jain, J. Moeller, V. Vogel, Mechanobiology of macrophages: how physical factors coregulate macrophage plasticity and phagocytosis,  <i>Ann. Rev. Biomed. Eng.<\/i>,  <b>21<\/b> (2019), 267\u2013297. https:\/\/doi.org\/10.1146\/annurev-bioeng-062117-121224","DOI":"10.1146\/annurev-bioeng-062117-121224"},{"key":"key-10.3934\/mbe.2022132-45","doi-asserted-by":"publisher","unstructured":"J. Lim, B. Choi, S. Lee, Y. Jang, J. Choi, Y. Kim, Regulation of wound healing by granulocyte-macrophage colony-stimulating factor after vocal fold injury,  <i>PLOS ONE<\/i>,  <b>8<\/b> (2013), e54256. https:\/\/doi.org\/10.1371\/journal.pone.0054256","DOI":"10.1371\/journal.pone.0054256"},{"key":"key-10.3934\/mbe.2022132-46","doi-asserted-by":"crossref","unstructured":"R. McFarlane, Patterns of the diseased fascia in the fingers in Dupuytren's contracture,  <i>Plast. Reconstr. Surg.<\/i>,  <b>54<\/b> (1974), 31\u201344. https:\/\/doi.org\/","DOI":"10.1097\/00006534-197407000-00004"},{"key":"key-10.3934\/mbe.2022132-47","doi-asserted-by":"publisher","unstructured":"D. Schwartz, Dupuytren's diathesis revisited: evaluation of prognostic indicators for risk of disease recurrence, <i>J. Hand Ther.<\/i>, <b>20<\/b> (2007), 280\u2013281. https:\/\/doi.org\/https:\/\/doi.org\/10.1197\/j.jht.2007.04.014","DOI":"10.1197\/j.jht.2007.04.014"},{"key":"key-10.3934\/mbe.2022132-48","doi-asserted-by":"publisher","unstructured":"C. Eaton, Evidence-based medicine: Dupuytren contracture,  <i>Plast Reconstr. Surg.<\/i>,  <b>133<\/b> (2014), 1239. https:\/\/doi.org\/10.1097\/PRS.0000000000000089","DOI":"10.1097\/PRS.0000000000000089"},{"key":"key-10.3934\/mbe.2022132-49","doi-asserted-by":"publisher","unstructured":"F. Syed, A. Thomas, S. S. ad V. Kolluru, S. Hart, A. Bayat, In vitro study of novel collagenase (XIAFLEX) on Dupuytren's disease fibroblasts displays unique drug related properties,  <i>PLOS ONE<\/i>,  <b>7<\/b> (2012), e31430. https:\/\/doi.org\/10.1371\/journal.pone.0031430","DOI":"10.1371\/journal.pone.0031430"},{"key":"key-10.3934\/mbe.2022132-50","doi-asserted-by":"publisher","unstructured":"A. Mantovani, M. Locati, Tumor-associated macrophages as a paradigm of macrophage plasticity, diversity, and polarization: lessons and open questions.,  <i>Arterioscler. Thromb. Vasc. Biol.<\/i>,  <b>33<\/b> (2013), 1478\u20131483. https:\/\/doi.org\/10.1161\/ATVBAHA.113.300168","DOI":"10.1161\/ATVBAHA.113.300168"},{"key":"key-10.3934\/mbe.2022132-51","doi-asserted-by":"publisher","unstructured":"C. Ferrante, S. Leibovich, Regulation of macrophage polarisation and wound healing,  <i>Adv. Wound Care<\/i>,  <b>1<\/b> (2012), 10\u201316. https:\/\/doi.org\/10.1089\/wound.2011.0307","DOI":"10.1089\/wound.2011.0307"},{"key":"key-10.3934\/mbe.2022132-52","doi-asserted-by":"publisher","unstructured":"S. Yotsukura, H. Mamitsuka, Evaluation of serum-based cancer biomarkers: a brief review from a clinical and computational viewpoint,  <i>Critical Reviews in Oncology\/Hematology<\/i>,  <b>93<\/b> (2015), 103\u2013115. https:\/\/doi.org\/10.1016\/j.critrevonc.2014.10.002","DOI":"10.1016\/j.critrevonc.2014.10.002"},{"key":"key-10.3934\/mbe.2022132-53","doi-asserted-by":"publisher","unstructured":"A. Bayat, D. McGrouther, Management of Dupuytren's disease - clear advice for an elusive condition,  <i>Ann. R. Coll. Surg. Engl.<\/i>,  <b>88<\/b> (2006), 3\u20138. https:\/\/doi.org\/10.1308\/003588406X83104","DOI":"10.1308\/003588406X83104"},{"key":"key-10.3934\/mbe.2022132-54","doi-asserted-by":"publisher","unstructured":"G. Dolmans, P. Werker, H. Hennies, D. Furniss, E. Festen, L. Franke, et al., Wnt signaling and Dupuytren's disease,  <i>N. Engl. J. Med<\/i>,  <b>365<\/b> (2011), 307\u2013317. https:\/\/doi.org\/10.1056\/NEJMoa1101029","DOI":"10.1056\/NEJMoa1101029"},{"key":"key-10.3934\/mbe.2022132-55","doi-asserted-by":"publisher","unstructured":"Y. Kim, J. Wallace, F. Li, M. Ostrowski, A. Friedman, Transformed epithelial cells and fibroblasts\/myofibroblasts interaction in breast tumour: a mathematical model and experiments,  <i>J. Math. Biol.<\/i>,  <b>61<\/b> (2010), 401\u2013421. https:\/\/doi.org\/10.1007\/s00285-009-0307-2","DOI":"10.1007\/s00285-009-0307-2"},{"key":"key-10.3934\/mbe.2022132-56","doi-asserted-by":"publisher","unstructured":"Y. Kim, A. Friedman, Interaction of tumour with its micro-environment: a mathematical model,  <i>Bull. Math. Biol.<\/i>,  <b>72<\/b> (2010), 1029\u20131068. https:\/\/doi.org\/10.1007\/s11538-009-9481-z","DOI":"10.1007\/s11538-009-9481-z"},{"key":"key-10.3934\/mbe.2022132-57","doi-asserted-by":"publisher","unstructured":"A. Friedman, Y. Kim, Tumour cell proliferation and migration under the influence of their microenvironment,  <i>Math. Biosci. Eng.<\/i>,  <b>8<\/b> (2011), 371\u2013383. https:\/\/doi.org\/10.3934\/mbe.2011.8.371","DOI":"10.3934\/mbe.2011.8.371"},{"key":"key-10.3934\/mbe.2022132-58","doi-asserted-by":"publisher","unstructured":"K. Norton, K. Jin, A. Popel, Modeling triple-negative breast cancer heterogeneity: effects of stromal macrophages, fibroblasts and tumour vasculature,  <i>J. Theor. Biol.<\/i>,  <b>452<\/b> (2018), 56\u201368. https:\/\/doi.org\/10.1016\/j.jtbi.2018.05.003","DOI":"10.1016\/j.jtbi.2018.05.003"},{"key":"key-10.3934\/mbe.2022132-59","doi-asserted-by":"publisher","unstructured":"N. Picco, E. Sahai, P. Maini, A. Anderson, Integrating models to quantify environment-mediated drug resistance,  <i>Cancer Res.<\/i>,  <b>77<\/b> (2017), 5409\u20135418. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-0835","DOI":"10.1158\/0008-5472.CAN-17-0835"},{"key":"key-10.3934\/mbe.2022132-60","doi-asserted-by":"publisher","unstructured":"R. Wadlow, B. Wittner, S. Finley, H. Bergquist, R. Upadhyay and S. Finn, et al., Systems-level modelling of cancer-fibroblast interaction,  <i>PLoS One<\/i>,  <b>4<\/b> (2009), e6888. https:\/\/doi.org\/10.1371\/journal.pone.0006888","DOI":"10.1371\/journal.pone.0006888"},{"key":"key-10.3934\/mbe.2022132-61","doi-asserted-by":"publisher","unstructured":"A. B. Tepole, E. Kuhl, Computational modelling of chemo-bio-mechanical coupling: a systems-biology approach toward wound healing,  <i>Comput. Methods Biomech. Biomed. Engin.<\/i>,  <b>19<\/b> (2016), 13\u201330. https:\/\/doi.org\/10.1080\/10255842.2014.980821","DOI":"10.1080\/10255842.2014.980821"},{"key":"key-10.3934\/mbe.2022132-62","doi-asserted-by":"publisher","unstructured":"R. Cooper, R. Segal, R. Diegelmann, A. Reynolds, Modelling the effects of systemic mediators on the inflammatory phase of wound healing,  <i>J. Theor. Biol.<\/i>,  <b>367<\/b> (2015), 86\u201399. https:\/\/doi.org\/10.1016\/j.jtbi.2014.11.008","DOI":"10.1016\/j.jtbi.2014.11.008"},{"key":"key-10.3934\/mbe.2022132-63","doi-asserted-by":"publisher","unstructured":"J. Dallon, J. Sherratt, P. Maini, Mathematical modelling of extracellular matrix dynamics using discrete cells: fiber orientation and tissue regeneration,  <i>J. Theor. Biol.<\/i>,  <b>199<\/b> (1999), 449\u2013471. https:\/\/doi.org\/10.1006\/jtbi.1999.0971","DOI":"10.1006\/jtbi.1999.0971"},{"key":"key-10.3934\/mbe.2022132-64","doi-asserted-by":"crossref","unstructured":"J. Flegg, S. Menon, P. Maini, D. McElwain, On the mathematical modelling of wound healing angiogenesis in skin as a reaction-transport process,  <i>Front. Physiol.<\/i>,  <b>6<\/b> (2015), 262. https:\/\/doi.org\/https:\/\/doi.org\/10.3389\/fphys.2015.00262","DOI":"10.3389\/fphys.2015.00262"},{"key":"key-10.3934\/mbe.2022132-65","doi-asserted-by":"publisher","unstructured":"S. Jorgensen, J. Sanders, Mathematical models of wound healing and closure: a comprehensive review,  <i>Med. Biol. Eng. Comput.<\/i>,  <b>54<\/b> (2016), 1297\u20131316. https:\/\/doi.org\/10.1007\/s11517-015-1435-z","DOI":"10.1007\/s11517-015-1435-z"},{"key":"key-10.3934\/mbe.2022132-66","doi-asserted-by":"publisher","unstructured":"D. Koppenol, F. Vermolen, F. Niessen, P. van Zuijlen, K. Vuik, A biomechanical mathematical model for the collagen bundle distribution-dependent contraction and subsequent retraction of healing dermal wounds,  <i>Biomech. Model. Mechanobiol.<\/i>,  <b>16<\/b> (2016), 345\u2013361. https:\/\/doi.org\/10.1007\/s10237-016-0821-2","DOI":"10.1007\/s10237-016-0821-2"},{"key":"key-10.3934\/mbe.2022132-67","doi-asserted-by":"publisher","unstructured":"S. McDougall, J. Dallon, J. Sherratt, P. Maini, Fibroblast migration and collagen deposition during dermal wound healing: mathematical modelling and clinical implications,  <i>Phil. Trans. R. Soc. A<\/i>,  <b>364<\/b> (2006), 1385\u20131405. https:\/\/doi.org\/10.1098\/rsta.2006.1773","DOI":"10.1098\/rsta.2006.1773"},{"key":"key-10.3934\/mbe.2022132-68","doi-asserted-by":"publisher","unstructured":"L. Olsen, J. Sherratt, P. Maini, A mechanochemical model for adult dermal wound contraction and the permanence of the contracted tissue displacement profile,  <i>J. Theor. Biol.<\/i>,  <b>177<\/b> (1995), 113\u2013128. https:\/\/doi.org\/10.1006\/jtbi.1995.0230","DOI":"10.1006\/jtbi.1995.0230"},{"key":"key-10.3934\/mbe.2022132-69","doi-asserted-by":"publisher","unstructured":"L. Olsen, J. Sherratt, P. Maini, A mathematical model for fibro-proliferative wound healing disorders,  <i>Bull. Math. Biol.<\/i>,  <b>58<\/b> (1996), 787\u2013808. https:\/\/doi.org\/10.1007\/BF02459482","DOI":"10.1007\/BF02459482"},{"key":"key-10.3934\/mbe.2022132-70","doi-asserted-by":"publisher","unstructured":"R. Tranquillo, J. Murray, Continuum model for fibroblast-driven wound contraction: inflammation mediation,  <i>J. Theor. Biol.<\/i>,  <b>158<\/b> (1992), 135\u2013172. https:\/\/doi.org\/10.1016\/s0022-5193(05)80715-5","DOI":"10.1016\/s0022-5193(05)80715-5"},{"key":"key-10.3934\/mbe.2022132-71","doi-asserted-by":"publisher","unstructured":"E. Valero, J. Garcia-Aznar, A. Menzel, M. Gomez-Benito, Challenges in the modelling of wound healing mechanisms in soft biological tissues,  <i>Ann. Biomed. Eng.<\/i>,  <b>43<\/b> (2014), 1654\u20131665. https:\/\/doi.org\/10.1007\/s10439-014-1200-8","DOI":"10.1007\/s10439-014-1200-8"},{"key":"key-10.3934\/mbe.2022132-72","doi-asserted-by":"publisher","unstructured":"Y. Wang, C. Guerrero\u2010Juarez, Y. Qiu, H. Du, W. Chen, S. Figueroa, et al., A multiscale hybrid mathematical model of epidermal-dermal interactions during skin wound healing,  <i>Exp. Dermatol.<\/i>,  <b>28<\/b> (2019), 493\u2013502. https:\/\/doi.org\/10.1111\/exd.13909","DOI":"10.1111\/exd.13909"},{"key":"key-10.3934\/mbe.2022132-73","doi-asserted-by":"publisher","unstructured":"H. Waugh, J. Sherratt, Modelling the effects of treating diabetic wounds with engineered skin substitutes,  <i>Wound Rep. Reg.<\/i>,  <b>15<\/b> (2007), 556\u2013565. https:\/\/doi.org\/10.1111\/j.1524-475X.2007.00270.x","DOI":"10.1111\/j.1524-475X.2007.00270.x"},{"key":"key-10.3934\/mbe.2022132-74","doi-asserted-by":"publisher","unstructured":"C. Xue, A. Friedman, C. Sen, A mathematical mode of ischemic cutaneous wounds,  <i>Proc. Natl. Acad. Sci. USA<\/i>,  <b>106<\/b> (2009), 16782\u201316787. https:\/\/doi.org\/10.1073\/pnas.0909115106","DOI":"10.1073\/pnas.0909115106"},{"key":"key-10.3934\/mbe.2022132-75","doi-asserted-by":"publisher","unstructured":"C. Ziraldo, Q. Mi, G. An, Y. Vodovotz, Computational modeling of inflammation and wound healing,  <i>Adv. wound care<\/i>,  <b>2<\/b> (2013), 527\u2013537. https:\/\/doi.org\/10.1089\/wound.2012.0416","DOI":"10.1089\/wound.2012.0416"},{"key":"key-10.3934\/mbe.2022132-76","doi-asserted-by":"publisher","unstructured":"F. Balkwill, M. Capasso, T. Hagemann, The tumour microenvironment at a glance,  <i>J. Cell Sci.<\/i>,  <b>125<\/b> (2012), 5591\u20135596. https:\/\/doi.org\/10.1242\/jcs.116392","DOI":"10.1242\/jcs.116392"},{"key":"key-10.3934\/mbe.2022132-77","doi-asserted-by":"publisher","unstructured":"J. Junker, E. Caterson, E. Eriksson, The microenvironment of wound healing,  <i>J. Craniofac. Surg.<\/i>,  <b>24<\/b> (2013), 12\u201316. https:\/\/doi.org\/10.1097\/SCS.0b013e31827104fb","DOI":"10.1097\/SCS.0b013e31827104fb"},{"key":"key-10.3934\/mbe.2022132-78","doi-asserted-by":"crossref","unstructured":"K. Chen, X. Hu, S. Blemker, J. Holmes, Multiscale computational model of Achilles tendon wound healing: Untangling the effects of repair and loading,  <i>PLoS Comput. Biol.<\/i>,  <b>14<\/b> (2018), e1006652. https:\/\/doi.org\/https:\/\/doi.org\/10.1371\/journal.pcbi.1006652","DOI":"10.1371\/journal.pcbi.1006652"},{"key":"key-10.3934\/mbe.2022132-79","doi-asserted-by":"publisher","unstructured":"R. Shuttleworth, D. Trucu, Multiscale modelling of fibres dynamics and cell adhesion within boundary cancer invasion,  <i>Bull. Math. Biol.<\/i>,  <b>81<\/b> (2019), 2176\u20132219. https:\/\/doi.org\/10.1007\/s11538-019-00598-w","DOI":"10.1007\/s11538-019-00598-w"},{"key":"key-10.3934\/mbe.2022132-80","doi-asserted-by":"publisher","unstructured":"J. Jansen, E. Gaffney, J. Wagg, M. Coles, Combining mathematical models with experimentation to drive novel mechanistic insights into macrophage function,  <i>Front. Immunol.<\/i>,  <b>10<\/b> (2019), 1283. https:\/\/doi.org\/10.3389\/fimmu.2019.01283","DOI":"10.3389\/fimmu.2019.01283"},{"key":"key-10.3934\/mbe.2022132-81","doi-asserted-by":"publisher","unstructured":"H. Warsinske, A. Wheaton, K. Kim, J. Linderman, B. Moore, D. Kirschner, Computational modeling predicts simultaneous targeting of fibroblasts and epithelial cells is necessary for treatment of pulmonary fibrosis,  <i>Front. Pharmacol.<\/i>,  <b>7<\/b> (2016), 183. https:\/\/doi.org\/10.3389\/fphar.2016.00183","DOI":"10.3389\/fphar.2016.00183"},{"key":"key-10.3934\/mbe.2022132-82","doi-asserted-by":"publisher","unstructured":"A. Oppelt, D. Kaschek, S. Huppelschoten, R. Sison-Young, F. Zhang and M. Buck-Wiese, et al., Model-based identification of TNF$\\alpha$-induced IKK$\\beta$-mediated and I$\\kappa$B$\\alpha$-mediated regulation of NF$\\kappa$B signal transduction as a tool to quantify the impact of drug-induced liver injury compounds,  <i>NPJ Syst. Biol. Appl.<\/i>,  <b>4<\/b> (2018), 23. https:\/\/doi.org\/10.1038\/s41540-018-0058-z","DOI":"10.1038\/s41540-018-0058-z"},{"key":"key-10.3934\/mbe.2022132-83","doi-asserted-by":"publisher","unstructured":"J. Moermans, Recurrences after surgery for Dupuytren's disease,  <i>Eur. J. Plast. Surg.<\/i>,  <b>20<\/b> (1997), 240\u2013245. https:\/\/doi.org\/10.1007\/BF01159481","DOI":"10.1007\/BF01159481"},{"key":"key-10.3934\/mbe.2022132-84","doi-asserted-by":"publisher","unstructured":"S. Rehman, R. Goodacre, P. Day, A. Bayat, H. Westerhoff, Dupuytren's: a systems biology disease,  <i>Arthritis Res. Ther.<\/i>,  <b>13<\/b> (2011), 238. https:\/\/doi.org\/10.1186\/ar3438","DOI":"10.1186\/ar3438"},{"key":"key-10.3934\/mbe.2022132-85","doi-asserted-by":"publisher","unstructured":"S. Rehman, P. Day, A. Bayat, H. Westerhoff, Understanding Dupuytren's disease using systems biology: a move away from reductionism,  <i>Front. Physiol.<\/i>,  <b>3<\/b> (2012), 316. https:\/\/doi.org\/10.3389\/fphys.2012.00316","DOI":"10.3389\/fphys.2012.00316"},{"key":"key-10.3934\/mbe.2022132-86","doi-asserted-by":"publisher","unstructured":"M. van Beuge, E. ten Dam, P. Werker, R. Bank, Wnt pathway in Dupuytren disease: connecting profibrotic signals, <i>Transl. Res.<\/i>, <b>166<\/b> (2015), 762\u2013771. https:\/\/doi.org\/10.1016\/j.trsl.2015.09.006","DOI":"10.1016\/j.trsl.2015.09.006"},{"key":"key-10.3934\/mbe.2022132-87","doi-asserted-by":"publisher","unstructured":"W. Du, O. Elemento, Cancer systems biology: embracing complexity to develop better anticancer therapeutic strategies,  <i>Oncogene<\/i>,  <b>34<\/b> (2015), 3215\u20133225. https:\/\/doi.org\/10.1038\/onc.2014.291","DOI":"10.1038\/onc.2014.291"},{"key":"key-10.3934\/mbe.2022132-88","doi-asserted-by":"crossref","unstructured":"I. Korsunsky, K. McGovern, T. LaGatta, L. Loohuis, T. Grosso-Applewhite and N. Griffeth, et al., Systems biology of cancer: a challenging expedition for clinical and quantitative biologists,  <i>Front. Bioeng. Biotechnol.<\/i>,  <b>2<\/b> (2014), 27. https:\/\/doi.org\/https:\/\/doi.org\/10.3389\/fbioe.2014.00027","DOI":"10.3389\/fbioe.2014.00027"},{"key":"key-10.3934\/mbe.2022132-89","doi-asserted-by":"publisher","unstructured":"M. Martins-Green, Y. Vodovotz, P. Liu, Systems biology applied to wound healing,  <i>Wound Repair Regen.<\/i>,  <b>18<\/b> (2010), 1\u20132. https:\/\/doi.org\/10.1111\/j.1524-475X.2009.00567.x","DOI":"10.1111\/j.1524-475X.2009.00567.x"},{"key":"key-10.3934\/mbe.2022132-90","doi-asserted-by":"publisher","unstructured":"Y. Vodovotz, Translational systems biology of inflammation and healing,  <i>Wound Repair Regen.<\/i>,  <b>18<\/b> (2010), 3\u20137. https:\/\/doi.org\/10.1111\/j.1524-475X.2009.00566.x","DOI":"10.1111\/j.1524-475X.2009.00566.x"},{"key":"key-10.3934\/mbe.2022132-91","doi-asserted-by":"publisher","unstructured":"H. Baltzer, P. Binhammer, Cost-effectiveness in the management of Dupuytren's contracture,  <i>Bone Joint J.<\/i>,  <b>95-B<\/b> (2013), 1094\u20131100. https:\/\/doi.org\/10.1302\/0301-620X.95B8.31822","DOI":"10.1302\/0301-620X.95B8.31822"},{"key":"key-10.3934\/mbe.2022132-92","doi-asserted-by":"publisher","unstructured":"M. Brazzelii, M. Cruickshank, E. Tassie, P. McNamee, C. Robertson, A. Elders, et al., Collagenase clostridium histolycum for the treatment of Dupuytren's contracture: a systematic review and economic evaluation,  <i>Health Technol. Assess.<\/i>,  <b>19<\/b> (2015), 90. https:\/\/doi.org\/10.3310\/hta19900","DOI":"10.3310\/hta19900"},{"key":"key-10.3934\/mbe.2022132-93","doi-asserted-by":"publisher","unstructured":"N. Chen, M. Shauver, K. Chung, Cost-effectiveness of open partial fasciectomy, needle aponeurotomy, and collagenase injection for Dupuytren contracture,  <i>J. Hand Surg. Am.<\/i>,  <b>36<\/b> (2011), 1826\u20131834. https:\/\/doi.org\/10.1016\/j.jhsa.2011.08.004","DOI":"10.1016\/j.jhsa.2011.08.004"},{"key":"key-10.3934\/mbe.2022132-94","doi-asserted-by":"publisher","unstructured":"M. Dritsaki, O. Rivero-Arias, A. Gray, C. Ball, J. Nanchahal, What do we know about managing Dupuytren's disease cost-effectively?,  <i>BMC Musculoskeletal Disord.<\/i>,  <b>19<\/b> (2018), 34. https:\/\/doi.org\/10.1186\/s12891-018-1949-2","DOI":"10.1186\/s12891-018-1949-2"},{"key":"key-10.3934\/mbe.2022132-95","doi-asserted-by":"publisher","unstructured":"C. Sau, M. Bounthavong, J. Tran, R. Wilson, Cost-utility analysis of collagenase clostridium histolycum, limited fasciectomy, and percutaneous needle fasciotomy in Dupuytren's contracture,  <i>Value Health<\/i>,  <b>14<\/b> (2011), A128. https:\/\/doi.org\/10.1016\/j.jval.2011.02.714","DOI":"10.1016\/j.jval.2011.02.714"},{"key":"key-10.3934\/mbe.2022132-96","doi-asserted-by":"publisher","unstructured":"M. Khashan, P. Smitham, W. Khan, N. Goddard, Dupuytren's disease: review of the current literature,  <i>Open Orthop. J.<\/i>,  <b>5<\/b> (2011), 283\u2013288. https:\/\/doi.org\/10.2174\/1874325001105010283","DOI":"10.2174\/1874325001105010283"},{"key":"key-10.3934\/mbe.2022132-97","doi-asserted-by":"publisher","unstructured":"I. Stura, D. Gabriele, C. Guiot, A simple PSA-based computational approach predicts the timing of cancer relapse in prostatectomised patients, <i>Cancer Res.<\/i>, <b>76<\/b> (2016), 4941\u20134947. https:\/\/doi.org\/10.1158\/0008-5472.CAN-16-0460","DOI":"10.1158\/0008-5472.CAN-16-0460"},{"key":"key-10.3934\/mbe.2022132-98","doi-asserted-by":"publisher","unstructured":"S. Hori, S. Gambhir, Mathematical model identified blood biomarker-based early cancer detection strategies and limitations,  <i>Sci. Transl. Med.<\/i>,  <b>3<\/b> (2011), 109ra116. https:\/\/doi.org\/10.1126\/scitranslmed.3003110","DOI":"10.1126\/scitranslmed.3003110"},{"key":"key-10.3934\/mbe.2022132-99","doi-asserted-by":"publisher","unstructured":"R. Eftimie, E. Hassanein, Improving cancer detection through combinations of cancer and immune biomarkers: a modelling approach,  <i>J. Transl. Med.<\/i>,  <b>16<\/b> (2018), 73. https:\/\/doi.org\/10.1186\/s12967-018-1432-8","DOI":"10.1186\/s12967-018-1432-8"},{"key":"key-10.3934\/mbe.2022132-100","doi-asserted-by":"publisher","unstructured":"M. McKenna, J. Weis, V. Quaranta, T. Yankeelov, Leveraging mathematical modeling to quantify pharmacokinetic and pharmacodynamic pathways: equivalent dose metric,  <i>Front. Physiol.<\/i>,  <b>10<\/b> (2019), 616. https:\/\/doi.org\/10.3389\/fphys.2019.00616","DOI":"10.3389\/fphys.2019.00616"}],"container-title":["Mathematical Biosciences and Engineering"],"original-title":[],"link":[{"URL":"http:\/\/www.aimspress.com\/article\/doi\/10.3934\/mbe.2022132?viewType=html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T09:54:25Z","timestamp":1642413265000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.aimspress.com\/article\/doi\/10.3934\/mbe.2022132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":100,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.3934\/mbe.2022132","relation":{},"ISSN":["1551-0018"],"issn-type":[{"type":"print","value":"1551-0018"}],"subject":[],"published":{"date-parts":[[2022]]}}}