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We present an approach to model the separate influences of each environmental quantity on the cells in a collective manner by introducing the \"environmental stress level\". It is an immeasurable auxiliary variable, which quantifies to what extent viable cells would get in a stressed state, if exposed to certain conditions. A high stress level can inhibit cell growth, promote cell death and influence cell movement. As a proof of concept, we compare two systems of ordinary differential equations, which model tumor cell dynamics under various nutrient saturations respectively with and without considering an environmental stress level. Particle-based Bayesian inversion methods are used to quantify uncertainties and calibrate unknown model parameters with time resolved measurements of &lt;italic&gt;in vitro&lt;\/italic&gt; populations of liver cancer cells. The calibration results of both models are compared and the quality of fit is quantified. While predictions of both models show good agreement with the data, there is indication that the model considering the stress level yields a better fitting. The proposed modeling approach offers a flexible and extendable framework for considering systems with additional environmental factors affecting the cell dynamics.&lt;\/p&gt;&lt;\/abstract&gt;<\/jats:p>","DOI":"10.3934\/mbe.2022258","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T05:13:11Z","timestamp":1648530791000},"page":"5509-5545","source":"Crossref","is-referenced-by-count":1,"title":["Environmental stress level to model tumor cell growth and survival"],"prefix":"10.3934","volume":"19","author":[{"given":"Sabrina","family":"Sch\u00f6nfeld","sequence":"first","affiliation":[{"name":"Center of Mathematics, Technical University of Munich, Garching, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alican","family":"Ozkan","sequence":"additional","affiliation":[{"name":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Scarabosio","sequence":"additional","affiliation":[{"name":"Institute for Mathematics, Astrophysics and Particle Physics, Radboud University, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa Nichole","family":"Rylander","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, The University of Texas, Austin, TX, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Kuttler","sequence":"additional","affiliation":[{"name":"Center of Mathematics, Technical University of Munich, Garching, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2321","reference":[{"key":"key-10.3934\/mbe.2022258-1","doi-asserted-by":"crossref","unstructured":"L. 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