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Results showed an increased risk of high GBP3 in Brain Lower Grade Glioma (LGG) and Lung Squamous Cell Carcinoma (LUSC) and a decreased risk of GBP3 in Sarcoma (SARC) and Skin Cutaneous Melanoma (SKCM) (p \u2264 0.05). GBP3 was negatively correlated with CAFs in Esophageal Adenocarcinoma (ESCA) and positively correlated with CAFs in LGG, LUSC and TGCG (p \u2264 0.05). In addition, GBP3 was positively correlated with CD8+ T cells in Bladder Urothelial Carcinoma (BLCA), Cervical Squamous Cell Carcinoma (CESC), Kidney Renal Clear Cell Carcinoma (KIRC), SARC, SKCM, SKCM-Metastasis and Uveal Melanoma (UVM) (p \u2264 0.05). Potentially, GBP3 may participate in the homeostasis between immune and adaptive immunity in cancers. Moreover, the most frequent mutation sites of GBP3 in cancers are R151Q\/&lt;sup&gt;*&lt;\/sup&gt; and K380N. This study would provide new insight into cancer prognosis and therapy.&lt;\/p&gt;\n\t\t&lt;\/abstract&gt;<\/jats:p>","DOI":"10.3934\/mbe.2023418","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T10:44:18Z","timestamp":1679395458000},"page":"9511-9529","source":"Crossref","is-referenced-by-count":2,"title":["The function of guanylate binding protein 3 (GBP3) in human cancers by pan-cancer bioinformatics"],"prefix":"10.3934","volume":"20","author":[{"given":"Tongmeng","family":"Jiang","sequence":"first","affiliation":[{"name":"Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China"},{"name":"Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices, Key Laboratory of Hainan Functional Materials and Molecular Imaging, Key Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Jin","sequence":"additional","affiliation":[{"name":"Health Science Center, Yangtze University, Jingzhou 434023, China"},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxiu","family":"Huang","sequence":"additional","affiliation":[{"name":"Health Management Center, The People's Hospital of Guangxi Zhuang Autonomous Region; Guangxi Health Examination Center, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region; Institute of Cardiovascular Sciences, Guangxi Academy of Medical Sciences, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2321","reference":[{"key":"key-10.3934\/mbe.2023418-1","doi-asserted-by":"publisher","unstructured":"J. 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