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The method assesses the reliability of DNA methylation data to distinguish the five most prevalent types of male cancers from normal tissues by employing DNA methylation 450K data obtained from The Cancer Genome Atlas (TCGA) database. First, the chi-square test is used for dimensionality reduction and second, L1 penalized logistic regression is used for feature selection. Furthermore, the stacking ensemble learning technique was employed to integrate seven common multiclassification models. Experimental results demonstrated that the ensemble learning model utilizing multiple classification models outperformed any base classification model. The proposed ensemble model achieved an astonishing overall accuracy (ACC) of 99.2% in independent testing data. Moreover, it may present novel ideas and pathways for the early detection and treatment of future diseases.&lt;\/p&gt;\n\t\t&lt;\/abstract&gt;<\/jats:p>","DOI":"10.3934\/mbe.2023845","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T06:22:24Z","timestamp":1697264544000},"page":"19133-19151","source":"Crossref","is-referenced-by-count":0,"title":["Integrative approach for classifying male tumors based on DNA methylation 450K data"],"prefix":"10.3934","volume":"20","author":[{"given":"Ji-Ming","family":"Wu","sequence":"first","affiliation":[{"name":"Computer Department, Jing-De-Zhen Ceramic University, Jingdezhen 333403, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang-Ren","family":"Qiu","sequence":"additional","affiliation":[{"name":"Computer Department, Jing-De-Zhen Ceramic University, Jingdezhen 333403, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi","family":"Liu","sequence":"additional","affiliation":[{"name":"Computer Department, Jing-De-Zhen Ceramic University, Jingdezhen 333403, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Chun","family":"Xu","sequence":"additional","affiliation":[{"name":"Computer Department, Jing-De-Zhen Ceramic University, Jingdezhen 333403, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shou-Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Jiangxi Provincial Children's Hospital, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2321","reference":[{"key":"key-10.3934\/mbe.2023845-1","doi-asserted-by":"publisher","unstructured":"H. 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