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To address these limitations, we applied the amplitude of low-frequency fluctuation (ALFF) results for the limbic system and cerebellar network as input data and conducted a binary hypothesis testing framework for ADHD biomarker detection. Our study on the ADHD-200 dataset at multiple sites resulted in an average classification accuracy of 93%, indicating strong discriminative power of the input brain regions between the ADHD and control groups. Moreover, our approach identified critical brain regions, including the thalamus, hippocampal gyrus, and cerebellum Crus 2, as biomarkers. Overall, this investigation uncovered potential ADHD biomarkers in the limbic system and cerebellar network through the use of ALFF realizing highly credible results, which can provide new insights for ADHD diagnosis and treatment.&lt;\/p&gt;&lt;\/abstract&gt;<\/jats:p>","DOI":"10.3934\/mbe.2024256","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T11:16:01Z","timestamp":1714302961000},"page":"5803-5825","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling critical ADHD biomarkers in limbic system and cerebellum using a binary hypothesis testing approach"],"prefix":"10.3934","volume":"21","author":[{"given":"Ying","family":"Chen","sequence":"first","affiliation":[{"name":"School of Microelectronics and Control Engineering, Changzhou University, Changzhou 213159, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lele","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Microelectronics and Control Engineering, Changzhou University, Changzhou 213159, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Microelectronics and Control Engineering, Changzhou University, Changzhou 213159, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibin","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Information Science and Engineering, Hohai University, Changzhou 213200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan","family":"Huan","sequence":"additional","affiliation":[{"name":"School of Microelectronics and Control Engineering, Changzhou University, Changzhou 213159, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2321","reference":[{"key":"key-10.3934\/mbe.2024256-1","doi-asserted-by":"publisher","unstructured":"G. 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