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The direction and strength of information flow between brain regions was investigated using directional phase transfer entropy (PTE). Compared to healthy controls, we observed an increased intensity of PTE information flow between the left and right hemispheres in the theta and alpha frequency bands in depressed subjects. The intensity of information flow between anterior and posterior regions within each hemisphere was reduced. Significant differences were found in the left supramarginal gyrus, right delta in the theta frequency band and bilateral lateral occipital lobe, and paracentral gyrus and parahippocampal gyrus in the alpha frequency band. The accuracy of cross-classification of directed PTE values with significant differences between groups was 91%. These findings suggest that altered information flow in the brains of depressed patients is related to the pathogenesis of depression, providing insights for patient identification and pathological studies.&lt;\/p&gt;<\/jats:p>","DOI":"10.3934\/mbe.2024315","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T12:46:10Z","timestamp":1727181970000},"page":"7124-7138","source":"Crossref","is-referenced-by-count":3,"title":["Depression-induced changes in directed functional brain networks: A source-space resting-state EEG study"],"prefix":"10.3934","volume":"21","author":[{"given":"Zhongwen","family":"Jia","sequence":"first","affiliation":[{"name":"School of Microelectronics and Control Engineering, Changzhou University, Jiangsu 213164, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihan","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Microelectronics and Control Engineering, Changzhou University, Jiangsu 213164, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jidong","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Microelectronics and Control Engineering, Changzhou University, Jiangsu 213164, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linhong","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering and Health Sciences, Changzhou University, Jiangsu 213164, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Microelectronics and Control Engineering, Changzhou University, Jiangsu 213164, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2321","reference":[{"key":"key-10.3934\/mbe.2024315-1","doi-asserted-by":"publisher","unstructured":"E. 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