{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:06:49Z","timestamp":1789567609714,"version":"build-2803163510"},"reference-count":59,"publisher":"American Institute of Mathematical Sciences (AIMS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AIMSMICRO"],"published-print":{"date-parts":[[2024]]},"abstract":"<p>Microneedles, a novel transdermal delivery system, were designed to improve drug delivery and address the challenges typically encountered with traditional injection practices. Discovering new and safe excipients for microneedle coating to replace existing chemical surfactants is advantageous to minimize their side effect on viable tissues. However, some side effects have also been observed for this application. The vast majority of studies suggest that using synthetic surfactants in microneedle formulations may result in skin irritation among other adverse effects. Hence, increasing knowledge about these components and their potential impacts on skin paves the way for finding preventive strategies to improve their application safety and potential efficacy. Biosurfactants, which are naturally produced surface active microbial products, are proposed as an alternative to synthetic surfactants with reduced side effects. The current review sheds light on potential and regulatory aspects of biosurfactants as safe excipients in the coating of microneedles.<\/p><\/jats:p>","DOI":"10.3934\/microbiol.2024028","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T02:21:43Z","timestamp":1722392503000},"page":"596-607","source":"Crossref","is-referenced-by-count":10,"title":["Potential of biosurfactant as green pharmaceutical excipients for coating of microneedles: A mini review"],"prefix":"10.3934","volume":"10","author":[{"given":"Marzieh Sajadi","family":"Bami","sequence":"first","affiliation":[{"name":"Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Khazaeli","sequence":"additional","affiliation":[{"name":"Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan Fakhraei","family":"Lahiji","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Biopharmaceutical Research Laboratory, Hanyang University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Dehghannoudeh","sequence":"additional","affiliation":[{"name":"Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M.","family":"Banat","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Life & Health Sciences, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandana","family":"Ohadi","sequence":"additional","affiliation":[{"name":"Pharmaceutics Research Center, Institute of Neuropharmacology, 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