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(2020) Dietary habits, lifestyle factors and neurodegenerative diseases.&nbsp;<i>Neural Regen Res<\/i>&nbsp;15: 394-400.","DOI":"10.4103\/1673-5374.266045"},{"key":"key-10.3934\/Neuroscience.2021021-143","doi-asserted-by":"crossref","unstructured":"Carratal\u00e0 J, Mykietiuk A, Fern\u00e1ndez-Sab\u00e9 N, et al. (2007) Health care-associated pneumonia requiring hospital admission: Epidemiology, antibiotic therapy, and clinical outcomes.&nbsp;<i>Arch Intern Med<\/i>&nbsp;167: 1393-1399.","DOI":"10.1001\/archinte.167.13.1393"},{"key":"key-10.3934\/Neuroscience.2021021-144","doi-asserted-by":"crossref","unstructured":"Corella D, Tucker K, Lahoz C, et al. 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(2013) Combined impact of smoking and heavy alcohol use on cognitive decline in early old age: Whitehall II prospective cohort study.&nbsp;<i>Br J Psychiatry<\/i>&nbsp;203: 120-125.","DOI":"10.1192\/bjp.bp.112.122960"},{"key":"key-10.3934\/Neuroscience.2021021-147","doi-asserted-by":"crossref","unstructured":"Esang M, Ahmed S (2018) A Closer Look at Substance Use and Suicide.&nbsp;<i>Am J Psychiatry Resid J<\/i>&nbsp;13: 6-8.","DOI":"10.1176\/appi.ajp-rj.2018.130603"},{"key":"key-10.3934\/Neuroscience.2021021-148","doi-asserted-by":"crossref","unstructured":"Bednarski SR, Zhang S, Hong KI, et al. (2011) Deficits in default mode network activity preceding error in cocaine dependent individuals.&nbsp;<i>Drug Alcohol Depend<\/i>&nbsp;119: e51-e57.","DOI":"10.1016\/j.drugalcdep.2011.05.026"},{"key":"key-10.3934\/Neuroscience.2021021-149","doi-asserted-by":"crossref","unstructured":"Fratiglioni L, Qiu C (2009) Prevention of common neurodegenerative disorders in the elderly.&nbsp;<i>Exp Gerontol<\/i>&nbsp;44: 46-50.","DOI":"10.1016\/j.exger.2008.06.006"},{"key":"key-10.3934\/Neuroscience.2021021-150","doi-asserted-by":"crossref","unstructured":"Karpyak VM, Biernacka JM, Geske JR, et al. (2016) Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states.&nbsp;<i>Addiction<\/i>&nbsp;111: 1366-1375.","DOI":"10.1111\/add.13386"},{"key":"key-10.3934\/Neuroscience.2021021-151","unstructured":"Djouss\u00e9 L, Myers RH, Province MA, et al. (2002) Influence of Apolipoprotein E, Smoking, and Alcohol Intake on Carotid Atherosclerosis National Heart, Lung, and Blood Institute Family Heart Study.&nbsp;<i>Stroke<\/i>&nbsp;33: 1357-1361."},{"key":"key-10.3934\/Neuroscience.2021021-152","doi-asserted-by":"crossref","unstructured":"Bhatti GK, Reddy AP, Reddy PH, et al. (2020) Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease.&nbsp;<i>Front Aging Neurosci<\/i>&nbsp;11: 369.","DOI":"10.3389\/fnagi.2019.00369"},{"key":"key-10.3934\/Neuroscience.2021021-153","doi-asserted-by":"crossref","unstructured":"Baghaiee B, Aliparasti MR, Almasi S, et al. (2016) Antioxidant expression response to free radicals in active men and women fallowing to a session incremental exercise; Numerical relationship between antioxidants and free radicals.&nbsp;<i>Asian J Sports Med<\/i>&nbsp;7: e29901.","DOI":"10.5812\/asjsm.29901"},{"key":"key-10.3934\/Neuroscience.2021021-154","doi-asserted-by":"crossref","unstructured":"Topiwala H, Terrera GM, Stirland L, et al. 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